Results 51 to 60 of about 6,019,041 (305)

miR-939-3p induces sarcoma proliferation and poor prognosis via suppressing BATF2

Frontiers in Oncology
BackgroundSarcoma is a rare and aggressive malignancy with poor prognosis, in which oncogene activation and tumor suppressor inactivation are involved.
Wanwen Xu, Yinghui Huang, Zengjie Lei, Jie Zhou   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Early recurrence and prognosis in patients undergoing resection of primary retroperitoneal sarcoma: an international, retrospective cohort studyResearch in context

EClinicalMedicine
Summary: Background: Complete surgical resection of retroperitoneal sarcomas (RPS) remains the cornerstone of potentially curative treatment. However, recurrence is common and timing of relapse is thought to reflect tumour biology. We aimed to determine
Alessandro Gronchi, Sara Iadecola, Juliana Restrepo-López, Deanna Ng, Francesco Barretta, Silva Ljevar, Costanza Figura, Wendy Johnston, Marco Fiore, Stefano Radaelli, Chiara Colombo, Carlo Morosi, Elena Di Blasi, Roberta Sanfilippo, Chiara Fabbroni, Silvia Stacchiotti, Rosalba Miceli, Rebecca A. Gladdy, Savtaj Brar, Sandro Pasquali, Dario Callegaro, Carol J. Swallow   +21 more
doaj   +1 more source

Cytokine Induced Killer cells are effective against sarcoma cancer stem cells spared by chemotherapy and target therapy.

OncoImmunology, 2018
Metastatic bone and soft tissue sarcomas often relapse after chemotherapy (CHT) and molecular targeted therapy (mTT), maintaining a severe prognosis. A subset of sarcoma cancer stem cells (sCSC) is hypothesized to resist conventional drugs and sustain ...
Giulia Mesiano, Giovanni Grignani, Erika Fiorino, Valeria Leuci, Ramona Rotolo, Lorenzo D’Ambrosio, Chiara Salfi, Loretta Gammaitoni, Lidia Giraudo, Alberto Pisacane, Sara Butera, Ymera Pignochino, Marco Basiricó, Federica Capozzi, Anna Sapino, Massimo Aglietta, Dario Sangiolo   +16 more
doaj   +1 more source

An experimental study of buckwheat polysaccharide in adjuvant therapy for S180 sarcoma mice

Archives of Medical Science, 2020
Introduction To discuss the auxiliary therapeutic effect of buckwheat polysaccharide (BP) on S180 sarcoma. Material and methods Buckwheat polysaccharide was extracted with water and precipitated with ethanol.
Duo-Jiao Fan, Peng Sun, Shu-Ying Han
doaj   +1 more source

Intracranial transplantation of the tumor induced by adenovirus type 12 in Syrian hamster--an experimental brain tumor model [PDF]

, 1971
A method of intracranial transplantation of the tumor induced by adenovirus type 12 in syrian hamster has been described. The incidence of intracranial tumor development was 86 (90.5 %) out of 95 animals and the average survival time and tumor size at ...
Tabuchi, Kazuo
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review

eLife, 2022
Background: Sarcomas comprise approximately 1% of all human malignancies; treatment resistance is one of the major reasons for the poor prognosis of sarcomas.
Huan-Huan Chen, Tie-Ning Zhang, Fang-Yuan Zhang, Tao Zhang   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Psychological adaptation and recovery in youth with sarcoma: a qualitative study with practical implications for clinical care and research

BMJ Open, 2020
Objectives This study explored factors that play a role in psychological adaptation and recovery of young people with sarcoma.Design Qualitative study.Setting National Health Service hospitals in the UK.Methods Using purposive sampling, participants were
Rachel M Taylor, Craig Gerrand, Ana Martins, Maria Onasanya, Rachael Windsor, Urska Kosir, Lucy Bowes   +6 more
doaj   +1 more source