Results 121 to 130 of about 65,186 (354)

Monitoring Sarcomere Structure Changes in Whole Muscle Using Diffuse Light Reflectance [PDF]

, 2006
doi:10.1117/1.2234278Normal biomechanical and physiological functions of striated muscles are facilitated by the repeating sarcomere units. Light scattering technique has been used in studying single extracted muscle fibers. However, few studies, if any,
Gerrard, David E., Weaver, Amanda, Xia, Jinjun, 1971-, Yao, Gang, Ph. D.   +3 more
core   +1 more source

Effect of Additional Terminal Residues on the Folding and Unfolding Dynamics of Cold Shock Protein

Advanced Science, EarlyView.
Enhancing protein stability through N‐ and C‐terminal modifications presents a safe and cost‐effective strategy. We investigated this by combining single‐molecule magnetic tweezers experiments and molecular dynamics simulations to study the folding and unfolding dynamics of CSP with various appended residues (LE‐CSP‐GS, KL‐CSP‐GS, KL‐CSP‐LE).
Dan Hu, Yang Wang, Huanjie Jiang, Hai Pan, Yunqiang Bian, Weitong Ren, Hu Chen, Zilong Guo, Yanwei Wang   +8 more
wiley   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging [PDF]

, 2017
Skeletal muscle is a key tissue in human aging, which affects different muscle fiber types unequally. We developed a highly sensitive single muscle fiber proteomics workflow to study human aging and show that the senescence of slow and fast muscle fibers
Ciciliot, Stefano, Mann, Matthias, Murgia, Marta, Nagaraj, Nagarjuna, Reggiani, Carlo, Schiaffino, Stefano, Toniolo, Luana, Vindigni, Vincenzo   +7 more
core   +3 more sources

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Frontiers in Pharmacology, 2019
Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes.
Alexandre J. S. Ribeiro, Brian D. Guth, Brian D. Guth, Michael Engwall, Sandy Eldridge, C. Michael Foley, Liang Guo, Gary Gintant, John Koerner, Stanley T. Parish, Jennifer B. Pierson, Mathew Brock, Khuram W. Chaudhary, Yasunari Kanda, Brian Berridge   +14 more
doaj   +1 more source

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

Prolonged Cell Encapsulation and Gravity‐independent Filamented Light Biofabrication of Muscle Constructs

Advanced Science, EarlyView.
A gravity‐independent filamented light (G‐FLight) projection method is presented for rapid biofabrication of anisotropic tissues, demonstrated with muscle constructs as a target application. Specialized photocrosslinkable resins enable refrigeration or cryopreservation with encapsulated cells.
Michael Winkelbauer, Jakub Janiak, Johannes Windisch, Hao Liu, Maria Bulatova, Max Von Witzleben, Hugo Oliveira, Sophie Dani, Richard Frank Richter, Nicolas L’Heureux, Ori Bar‐Nur, Michael Gelinsky, Marcy Zenobi‐Wong, Parth Chansoria   +13 more
wiley   +1 more source

Are the class 18 myosins Myo18A and Myo18B specialist sarcomeric proteins?

Frontiers in Physiology
Initially, the two members of class 18 myosins, Myo18A and Myo18B, appeared to exhibit highly divergent functions, complicating the assignment of class-specific functions.
Markus Horsthemke, Charles-Adrien Arnaud, Charles-Adrien Arnaud, Peter J. Hanley   +3 more
doaj   +1 more source

Targeting the sarcomere in inherited cardiomyopathies

Nature Reviews Cardiology, 2022
Sarah J. Lehman, C. Crocini, L. Leinwand
semanticscholar   +1 more source