Results 131 to 140 of about 65,186 (354)
Advanced Intelligent Systems, EarlyView.A six‐element viscoelastic model is presented for tissue‐engineered skeletal muscle, addressing the limitations of the conventional Hill's model. By introducing an active branch, the model accurately describes force responses in both elongation and isometric tests and successfully predicts the electrically induced displacement of a reverse‐action ...
Mizuki Nakamura +6 more
wiley +1 more source
Frontiers in Cell and Developmental BiologyLifeact is a short peptide that is widely utilized as a probe for actin filaments in live imaging. However, high concentrations of Lifeact can alter actin filament dynamics and cause artificial modifications to the actin cytoskeleton.
Shoichiro Ono, Shoichiro Ono
doaj +1 more source
Sarcomere dynamics during muscular contraction and their implications to muscle function [PDF]
, 2018 This article attempts to identify the key aspects of sarcomere inhomogeneity and the dynamics of sarcomere length changes in muscle contraction experiments and focuses on understanding the mechanics of myofibrils or muscle fibres when viewed as ...
Denoth, Jachen, Telley, Ivo
core
Development of an efficient mice model of cancer‐associated cardiac cachexia
Animal Models and Experimental Medicine, EarlyView.This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong +9 more
wiley +1 more source
eLife, 2013 microRNA-1 (miR-1) is an evolutionarily conserved, striated muscle-enriched miRNA. Most mammalian genomes contain two copies of miR-1, and in mice, deletion of a single locus, miR-1-2, causes incompletely penetrant lethality and subtle cardiac defects ...
Amy Heidersbach +7 more
doaj +1 more source
Nature Cell Biology, 2015 Cells test the rigidity of the extracellular matrix by applying forces to it through integrin adhesions. Recent measurements show that these forces are applied by local micrometre-scale contractions, but how contraction force is regulated by rigidity is ...
Haguy Wolfenson +9 more
semanticscholar +1 more source
Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. [PDF]
, 2019 Biological roles of obscurin and its close homolog Obsl1 (obscurin-like 1) have been enigmatic. While obscurin is highly expressed in striated muscles, Obsl1 is found ubiquitously.
Blondelle, Jordan +13 more
core +1 more source
Incidence and Prevalence of Congenital Myopathies ‐ A Population‐Based Study From Western Sweden
Annals of Neurology, EarlyView.Objective Congenital myopathies are a group of rare genetic muscle disorders. Previous studies have estimated point prevalences which only include surviving individuals. Our aim was to perform an epidemiological study with strict inclusion criteria, using modern diagnostic technology to present both incidences and prevalences, and to describe the ...
Eva Michael +5 more
wiley +1 more source
Mechanical signaling in the pathophysiology of critical illness myopathy
Frontiers in Physiology, 2016 The complete loss of mechanical stimuli of skeletal muscles, i.e., the loss of external strain, related to weight bearing, and internal strain, related to the contraction of muscle cells, is uniquely observed in pharmacologically paralyzed or deeply ...
Rebeca Corpeño Kalamgi +2 more
doaj +1 more source
Impact of \u3cem\u3eMYH6\u3c/em\u3e Variants in Hypoplastic Left Heart Syndrome [PDF]
, 2016 Hypoplastic left heart syndrome (HLHS) is a clinically and anatomically severe form of congenital heart disease (CHD). Although prior studies suggest that HLHS has a complex genetic inheritance, its etiology remains largely unknown.
Benson, D. Woodrow +13 more
core +2 more sources