Results 151 to 160 of about 35,307 (294)

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Sarcomere [PDF]

, 2020
openaire   +1 more source

Effects of chemical myosin II cross‐bridge inhibitors on eccentric force production in skinned muscle fibres

Experimental Physiology, EarlyView.
Abstract Eccentric muscle contractions are essential for locomotion and daily activities. Force during these contractions depends on both cross‐bridge (XB) and non‐cross‐bridge (non‐XB) elements, including titin, with contributions varying by fibre type and contraction velocity.
André Tomalka, Sven Weidner, Christian Rode, Tobias Siebert   +3 more
wiley   +1 more source

Subsarcomeric regulation of thin and thick filaments in skeletal muscle myofibrils. [PDF]

Proc Natl Acad Sci U S A
Sliogeryte K, Fusi L.
europepmc   +2 more sources

Phosphate and acidosis cause fibre‐typespecific changes to cellular and molecular contractile mechanics at 37°C in skeletal muscle from older adults

Experimental Physiology, EarlyView.
Abstract Intracellular accumulation of hydrogen ions (H+) and inorganic phosphate (Pi) has temperature‐dependent effects on single‐fibre contractile function between 10°C and 30°C. In vivo, human skeletal muscle temperatures range between 35‐39°C, and although contractile function is highly dependent on temperature, the effects of fatigue‐inducing [H+]
Brent A. Momb, Jane A. Kent, Stuart R. Chipkin, Mark S. Miller   +3 more
wiley   +1 more source

Longitudinal sarcomere dynamics of skeletal muscle

, 2010
The issue of variation in sarcomere behaviour during contraction is important to skeletal muscle mechanics; however, few studies have measured sarcomere length throughout a contracting muscle.
Freeman, Marcus Joseph
core  

Cartoon demonstrating an example labeling scheme with three same-host primary antibodies with corresponding sarcomere locations across a half-sarcomere.

Numbers in black circles correspond to the individual incubation steps listed. (1) α-Actinin antibody is used to label the sarcomere Z-disc. (2) AlexaFluor 647 secondary antibody is used to label α-Actinin antibody.
Collin M. Douglas (14305221), Daniel Kopinke (18468689), Jonathan E. Bird (18468686), Karyn A. Esser (14305230)   +3 more
core   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

M-band: a safeguard for sarcomere stability? [PDF]

, 2018
The sarcomere of striated muscle is a very efficient machine transforming chemical energy into movement. However, a wrong distribution of the generated forces may lead to self-destruction of the engine itself.
Perriard, Jean-Claude, Schoenauer, Roman, Ehler, Elisabeth, Lange, Stephan, Agarkova, Irina   +4 more
core  

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source