Results 171 to 180 of about 51,464 (286)

Phase-targeting rapid cryofixation of the beating heart and histological analysis unveil contractile state-dependent sarcomere dynamics. [PDF]

Sci Rep
Tamura S, Mochizuki K, Kumamoto Y, Morishita Y, Yamanaka M, Ho WJ, Harada Y, Fujita K, Tanaka H.   +8 more
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Distinct distributions of myosin motor conformations during contraction of slow and fast skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend We recorded time‐resolved small‐angle X‐ray diffraction patterns from rat soleus muscles during fixed‐end twitch and tetanic contractions to investigate the structural basis of the lower fixed‐end force generated by these muscles compared with fast muscles, such as the mouse extensor digitorum longus (EDL).
Cameron Hill, Michaeljohn Kalakoutis, Alice Arcidiacono, Yanhong Wang, Emma Smith, Elisabetta Brunello, Luca Fusi, Malcolm Irving   +7 more
wiley   +1 more source

Titin's P-zone domains A164-167 are essential for thick filament structural arrangement. [PDF]

J Gen Physiol
Hoover Browne C, Han SW, Farman GP, Smith JE, Kolb J, Gohlke J, Langlais PR, Tonino P, Methawasin M, van der Pijl R, Granzier H.   +10 more
europepmc   +1 more source

SarcGraph for High-Throughput Regional Analysis of Sarcomere Organization and Contractile Function in 2D Cardiac Muscle Bundles. [PDF]

MicroPubl Biol
Mohammadzadeh S, Tsan YC, Renberg A, Kobeissi H, Helms A, Lejeune E.   +5 more
europepmc   +1 more source

Sarcomeric mutations in cardiac diseases [PDF]

Pflügers Archiv - European Journal of Physiology, 2019
Samantha P. Harris, Pieter P. de Tombe
openaire   +2 more sources

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism. [PDF]

Sci Adv
Hibbert JE, Jorgenson KW, Sayed RKA, Paez HG, Meinhold M, Flynn CGK, Lange AN, Lindley GT, Flejsierowicz PM, Hornberger TA.   +9 more
europepmc   +1 more source

Impact of Freezing on the Nanoarchitecture and Techno‐Functional Properties of Camel Myofibrillar Proteins: Insights From Atomic Force Microscopy

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Schematic overview of the extraction of camel myofibrillar proteins from Longissimus lumborum (LL) and Biceps femoris (BF) muscles and the evaluation of freezing‐induced changes. The study integrates techno‐functional analyses (protein solubility, surface hydrophobicity, reactive sulfhydryl groups, SDS–PAGE) with nanoarchitectural characterization ...
Ahmed‐Laloui Hamza, Rahmani Abderrahmen, Cherb Nora, Bendjaballah Sandra, Ramdani Nacira, Maqsood Sajid, Seid Mahdi Jafari   +6 more
wiley   +1 more source

Western Diet-Induced Impairment of Left Atrium Cardiomyocyte Contractility in Female Wistar Rats Is Associated with Slowdown in the Cross-Bridge Cycle and Dephosphorylation of cMyBP-C. [PDF]

Int J Mol Sci
Mukhlynina E, Butova X, Myachina T, Simonova R, Antonets Y, Leiberova A, Kochurova A, Gusarova E, Chumarnaya T, Kopylova G, Shchepkin D.   +10 more
europepmc   +1 more source