Emerging Upper Extremity Muscle Ultrasound Patterns as a Diagnostic Aid in TTN‐Related Myopathies
ABSTRACT Introduction/Aims Biallelic pathogenic variants in TTN cause rare forms of early‐onset myopathy, manifesting with variable severity, distribution, and progression of muscle weakness, often associated with respiratory insufficiency and potentially cardiomyopathy. The large size of TTN and phenotypic heterogeneity in TTN‐related myopathy (TTN‐RM)
Abigail Potticary +3 more
wiley +1 more source
The roles of the microtubule cytoskeletal network in cardiac mechanobiology. [PDF]
Murphy JF, Li X.
europepmc +1 more source
Shear Wave Elastography to Assess Respiratory Muscle Function in Congenital Myopathies
ABSTRACT Introduction/Aims Respiratory muscle dysfunction is prevalent in congenital myopathies and often leads to respiratory failure. Ultrasound shear wave elastography (SWE) measures tissue elasticity and has been proposed as an alternative to invasive measures of respiratory muscle contractility.
J. L. M. van Doorn +8 more
wiley +1 more source
ABSTRACT Background and Purpose The massage gun is widely used to alleviate delayed‐onset muscle soreness (DOMS); however, empirical evidence regarding its physiological effects remains limited. Objectives This study aimed to evaluate the acute effects of percussive massage on the quadriceps muscle's cross‐sectional area (CSA), strength performance ...
Aline da Rosa Castilho +6 more
wiley +1 more source
Cell shape and maturation impacts α-actinin-2 tension in iPSC-derived cardiomyocytes. [PDF]
Dutta PK +14 more
europepmc +1 more source
Myosin Post‐Translational Modifications Associated With Critical Illness Myopathy
ABSTRACT Background Critical illness myopathy is a common and devastating consequence of critical care, causing dramatic loss of muscle mass and function in intensive care unit patients. Functional deficits often exceed the loss in muscle mass and myosin content.
Fernando Ribeiro +9 more
wiley +1 more source
SarcGraph for High-Throughput Regional Analysis of Sarcomere Organization and Contractile Function in 2D Cardiac Muscle Bundles. [PDF]
Mohammadzadeh S +5 more
europepmc +1 more source
Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem +2 more
wiley +1 more source
Osimertinib induces reversible cardiac dysfunction through the GATA4-MYLK3-MYL2 axis. [PDF]
Zhang K +20 more
europepmc +1 more source
Architecture of lower leg muscles in children: Reference curves and potential mechanisms of growth
Muscle architecture (physiological cross‐sectional area, fascicle lengths and pennation angle) was measured from multimodal MRI scans of the lower legs of 197 children aged ≤15 years. We showed that lower leg muscle volumes (product of PCSA and fascicle length) increase primarily through increases in PCSA (transverse growth) rather than increases in ...
Brian V. Y. Chow +12 more
wiley +1 more source

