Results 201 to 210 of about 29,455 (242)
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Dysfunctional sarcomeric relaxation in the heart
Current Opinion in Physiology, 2022Since cardiac relaxation is commonly impaired in heart failure caused by many different etiologies, identifying druggable targets is a common goal. While many factors contribute to cardiac relaxation, this review focuses on sarcomeric relaxation and dysfunction.
Walter E, Knight, Kathleen C, Woulfe
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Targeting the sarcomere in inherited cardiomyopathies
Nature Reviews Cardiology, 2022Variants in >12 genes encoding sarcomeric proteins can cause various cardiomyopathies. The two most common are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Current therapeutics do not target the root causes of these diseases, but attempt to prevent disease progression and/or to manage symptoms.
Sarah J. Lehman +2 more
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Force produced by isolated sarcomeres and half-sarcomeres after an imposed stretch
American Journal of Physiology-Cell Physiology, 2012When a stretch is imposed to activated muscles, there is a residual force enhancement that persists after the stretch; the force is higher than that produced during an isometric contraction in the corresponding length. The mechanisms behind the force enhancement remain elusive, and there is disagreement if it represents a sarcomeric property, or if it
Dilson E, Rassier, Ivan, Pavlov
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Sarcomeric Genotyping in Hypertrophic Cardiomyopathy
Mayo Clinic Proceedings, 2005To pool results from studies of patients with hypertrophic cardiomyopathy (HCM) to elucidate important phenotypic differences among genotypes.Data published from November 1998 through November 2004 were gathered and compared from unrelated study population genotyping studies from the Mayo Clinic (Rochester, Minn), Harvard Medical School (Boston, Mass),
Sara L, Van Driest +4 more
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2010
Skeletal muscle cells, more commonly called muscle fibres, are multinucleated syncytia formed during development by fusion of mononucleated precursor cells, the myoblasts. They measure 10–100 μm in diameter and can have lengths from a few millimeters up to almost a meter.
Margit Pavelka, Jürgen Roth
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Skeletal muscle cells, more commonly called muscle fibres, are multinucleated syncytia formed during development by fusion of mononucleated precursor cells, the myoblasts. They measure 10–100 μm in diameter and can have lengths from a few millimeters up to almost a meter.
Margit Pavelka, Jürgen Roth
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Myofilaments: Movers and Rulers of the Sarcomere
Comprehensive Physiology, 2017ABSTRACT Striated cardiac and skeletal muscles play very different roles in the body, but they are similar at the molecular level. In particular, contraction, regardless of the type of muscle, is a precise and complex process involving the integral protein myofilaments and their associated regulatory components ...
Brian Leei, Lin +2 more
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Atomistic Simulations of Sarcomere Proteins
2023Concerted atomic motions are requisite for sarcomere protein function and may become disrupted in HCM pathologies. Computational approaches such as molecular dynamics simulation can resolve such dynamics with unrivalled spatial and temporal resolution.
Matthew Carter, Childers +1 more
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1989
Studies on the mechanics of sarcomeres at the level of single myofibrils or single myocytes revealed properties not predicted by the cross-bridge theory of muscle contraction. This paper summarizes four major aspects: 1. Passive compression of the sarcomere showed two inflections in the force length curve; one was at the length where opposing ...
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Studies on the mechanics of sarcomeres at the level of single myofibrils or single myocytes revealed properties not predicted by the cross-bridge theory of muscle contraction. This paper summarizes four major aspects: 1. Passive compression of the sarcomere showed two inflections in the force length curve; one was at the length where opposing ...
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Architecture and function in the muscle sarcomere
Current Opinion in Structural Biology, 1997Striated muscle sarcomeres in vertebrates comprise ordered arrays of actin and myosin filaments, organized by an elaborate protein scaffold. Recent innovative work in a number of laboratories has greatly improved our knowledge of these structures, their organization and their interactions.
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The molecular basis for sarcomere organization in vertebrate skeletal muscle
Cell, 2021Stefan Raunser +2 more
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