Results 161 to 170 of about 35,307 (294)

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source

Insights from electromechanical simulations to assess omecamtiv mecarbil efficacy in heart failure

The Journal of Physiology, EarlyView.
Abstract figure legend Impact of Omecamtiv Mecarbil (OM) on in‐silico models of heart failure. A mathematical electromechanical model of human ventricular tissue is used to simulate the effects of OM in heart failure with reduced ejection fraction (HFrEF).
Maria Teresa Mora, Ilse van Herck, Cécile Daversin‐Catty, Henrik Finsberg, Jordi Llopis‐Lorente, Javier Saiz, Hermenegild Arevalo, Samuel Wall, Beatriz Trenor   +8 more
wiley   +1 more source

Metabolite‐sensitive cross‐bridge models of human atria reveal the impact of diabetes on muscle mechanoenergetics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we used mathematical modelling to explore the effect of diabetes on muscle mechanoenergetics. Our parameterisation of cross‐bridge models using data from non‐diabetic and diabetic human atrial tissues revealed lower values for cross‐bridge stiffness, detachment rates, attachment rates and lower ATP sensitivity in ...
Julia H. Musgrave, June‐Chiew Han, Marie‐Louise Ward, Andrew J. Taberner, Kenneth Tran   +4 more
wiley   +1 more source

A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend 3D cardiomyocyte segmentation enables comprehensive analyses of myocardial microstructure in health and disease; however, it is technically demanding. We present an open‐source toolkit for this task, which reduces challenges associated with sample preparation, image restoration, segmentation and proofreading.
Joachim Greiner, Fabio Frangiamore, Frédéric Sonak, Josef Madl, Thomas Seidel, Peter Kohl, Eva A. Rog‐Zielinska   +6 more
wiley   +1 more source

Sarcomere Gene Mutation correction [PDF]

European Heart Journal, 2018
Sanjiv, Kaul, Stephen B, Heitner, Shoukhrat, Mitalipov   +2 more
openaire   +2 more sources

Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis.

BACKGROUND: Recent interest in understanding cardiomyocyte cell cycle has been driven by potential therapeutic applications in cardiomyopathy. However, despite recent advances, cardiomyocyte mitosis remains a poorly understood process. For example, it is
Elhelaly, Waleed M, Hill, Joseph A, Kimura, Wataru, Luo, Xiang, Lam, Nicholas T, Xiao, Feng, Kanchwala, Mohammed, Nguyen, Ngoc Uyen Nhi, Elhelaly, Waleed, Li, Shujuan, Sadek, Hesham A, Wang, Ping, Pereira, Ana Helena Macedo, Sadayappan, Sakthivel, Hajjar, Roger J, Hsu, Ching-Cheng, Singh, Rohit, Thet, Suwannee, Cardoso, Alisson Campos, Xing, Chao, Ladha, Feria A, Hinson, J Travis, Menendez-Montes, Ivan   +22 more
core   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Editorial: Recent Advances on Myocardium Physiology, Volume II

Frontiers in Physiology, 2023
Norio Fukuda, Henk Granzier, Shin’ichi Ishiwata, Sachio Morimoto   +3 more
doaj   +1 more source

Targeting intracellular cholesterol imbalance rescues sarcomere-ER contact site signaling and ER remodeling in dilated cardiomyopathy. [PDF]

Signal Transduct Target Ther
Ignatyeva N, Cheruiyot C, Saleem HN, Wali R, Plota D, Zhang W, Schön S, Brandenburg S, Yang Z, Steyer A, Urlaub H, Rasmussen T, Mogensen J, Pronto JRD, Döring Y, Radke MH, Shcherbata H, Lehnart SE, Janshoff A, Sossalla S, Ruhwedel T, Moebius W, Toischer K, Brügger B, Haucke V, Gotthardt M, Voigt N, Ebert A.   +27 more
europepmc   +1 more source