Results 161 to 170 of about 29,455 (242)

Osimertinib induces reversible cardiac dysfunction through the GATA4-MYLK3-MYL2 axis. [PDF]

Eur Heart J
Zhang K, Ayala A, Norambuena-Soto I, Agnihotri V, Shu T, Nenninger C, Wang Y, Echevarria B, Aboagye J, Huang K, Espitia-Corredor J, Wu X, Chen ZB, Deng Y, Perry JJP, Raz DJ, Yang H, Cheng P, Fu G, Wang ZV, Rhee JW.   +20 more
europepmc   +1 more source

Coronary Microvascular Dysfunction: Epidemiology, Pathophysiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 8, August 2026.
This visual summary illustrates the key aspects of coronary microvascular dysfunction (CMD) in angina with nonobstructive coronary artery disease (NOCAD), including epidemiology, pathophysiology (microvascular remodeling and endothelial dysfunction), the protective NRG‐1/ErbB signaling pathway, diagnostic methods, and both Western and traditional ...
Zhao Ge, MaoZe Zhang, Xujin Ning, Yijia Du, Lishuo Su, Xudong Wu, Jingyi Zhang, Tongzuo Liu, Xianliang Wang   +8 more
wiley   +1 more source

Cardiovascular Diseases and Cancer: Convergent Proteostasis Networks at the Crossroads of Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
The disruption of proteostasis, encompassing the ubiquitin–proteasome system, autophagy, UPR/ER stress, and chaperone function, represents a fundamental mechanism shared by both cancer and cardiovascular diseases. While these pathways frequently facilitate tumor progression, they are crucial for maintaining proteostasis in cardiac tissue. Consequently,
Jacob Eli García Torres, Norbert Frey, Ashraf Yusuf Rangrez   +2 more
wiley   +1 more source

Titin's P-zone domains A164-167 are essential for thick filament structural arrangement. [PDF]

J Gen Physiol
Hoover Browne C, Han SW, Farman GP, Smith JE, Kolb J, Gohlke J, Langlais PR, Tonino P, Methawasin M, van der Pijl R, Granzier H.   +10 more
europepmc   +1 more source

Transcriptomic comparative study between canalicular adenoma and HMGA2::WIF1 canalicular‐like pleomorphic adenoma

The Journal of Pathology, Volume 269, Issue 4-5, Page 423-432, August 2026.
Abstract Canalicular adenoma (CA) is a benign salivary gland tumor predominantly affecting the upper lip and is characterized by monomorphic epithelial cells arranged in branching cords within a loose and vascularized stroma. Unlike pleomorphic adenoma (PA), CA lacks a chondroid matrix and exhibits specific histological features, such as high cuboidal ...
Ziyad Alsugair, Anne Champagnac, Maxime Fieux, Pierre Philouze, Philippe Ceruse, Brice Thamphya, Daniel Pissaloux, Franck Tirode, Nazim Benzerdjeb   +8 more
wiley   +1 more source

Selective titin cleavage disrupts cardiac mechanical homeostasis to drive heart failure and fibrosis. [PDF]

Nat Cardiovasc Res
Freundt JK, Hartmann P, Loescher CM, Unger A, Koser F, Klotz AJ, Wildschütz L, Wachsmuth L, Hille S, Door MM, Helfen A, Holtmeier R, Faber C, Kirk JA, Hoerr V, Müller OJ, Linke WA.   +16 more
europepmc   +1 more source

Construction and Validation of Plasma Protein‐Based Musculoskeletal Biological Age and Genetic and Environmental Risk Profiles

Aging Cell, Volume 25, Issue 8, August 2026.
We developed plasma protein‐based musculoskeletal aging clocks, MSKAge and MSKAgeMort, using UK Biobank proteomic data, and showed that MSKAgeAccel and MSKAgeMortAccel (in particular) predicted mortality, musculoskeletal disorders, and age‐related diseases effectively.
Yangdan Zhong, Maoyao Xia, Xunying Zhao, Yang Qu, Bowen Lei, Sirui Zhen, Tao Han, Rong Xiang, Jinyu Xiao, Xin Song, Xiaofeng Ma, Bin Yang, Di Zhang, Jinyu Zhou, Zilan Chen, Yuqi Pang, Ye Ju, Ting Liu, Zihao Li, Lu Long, Tao Zhang, Jiayuan Li, Mengyu Fan, Zuyun Liu, Xia Jiang   +24 more
wiley   +1 more source

Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism. [PDF]

Sci Adv
Hibbert JE, Jorgenson KW, Sayed RKA, Paez HG, Meinhold M, Flynn CGK, Lange AN, Lindley GT, Flejsierowicz PM, Hornberger TA.   +9 more
europepmc   +1 more source

Altered Skeletal Muscle Phosphate Metabolism After Muscle Damage Is Associated With Elevated Effort Perception During Exercise in Humans

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 8, August 2026.
ABSTRACT It remains unclear why exercising damaged muscles is perceived as disproportionately more effortful. Given the known role of inorganic phosphate (Pi) in fatigue and afferent sensory signaling, we tested whether muscle damage disrupts phosphate metabolism and whether this is associated with heightened ratings of perceived exertion (RPE ...
Jamie Stewart McPhee, Aneurin James Kennerley, Jean‐Christophe Lagacé, James McStravick, Susan Pinner, Fabio Zambolin   +5 more
wiley   +1 more source

Eccentric Exercise and Muscle Damage: An Introductory Guide. [PDF]

J Funct Morphol Kinesiol
Paschalis V, Margaritelis NV, Chatzinikolaou PN, Theodorou AA, Nikolaidis MG.   +4 more
europepmc   +1 more source