Results 141 to 150 of about 65,186 (354)
From sarcomeres to whole muscles [PDF]
Journal of Experimental Biology, 1985 ABSTRACT The series connection of sarcomeres in a muscle raises the possibility of instabilities due to some sarcomeres being capable of greater isometric tension than others, due to non-uniform activation, cross-sectional area or sarcomere length.
openaire +3 more sources
Tuning Cellular Perception in Pluripotent Stem Cells through Topography, Stiffness, and Patterning
Advanced NanoBiomed Research, EarlyView.Micro‐ and nanotopographical cues, substrate stiffness, and mechanical patterning synergistically direct pluripotent stem cell fate and function by tuning cellular perception at the biointerface. Pluripotent stem cells (PSCs), comprised of embryonic stem cells and induced PSCs, hold tremendous therapeutic potential.
Yuan Jiang +7 more
wiley +1 more source
Muscle contraction: Sliding filament history, sarcomere dynamics and the two Huxleys
Global Cardiology Science & Practice, 2016 Despite having all the evidence needed to come to the right conclusions in the middle of the 1800s, it was not until the 1950s that it was realised by two unrelated Huxleys and their collaborators that striated muscle sarcomeres contain overlapping sets ...
J. Squire
semanticscholar +1 more source
Cytoskeleton, EarlyView.ABSTRACT Sarcomeres are the fundamental contractile units of striated muscle. The functional roles of the cardiac‐specific myosin heavy chains, MYH6 (α myosin II) and MYH7 (β myosin II) during sarcomere assembly remain controversial. To address this, we utilized a selective MYH7 inhibitor, mavacamten, in combination with siRNA‐mediated knockdown of ...
James B. Hayes, Dylan T. Burnette
wiley +1 more source
Royal Society Open Science, 2016 The sarcomere length non-uniformity theory (SLNT) is a widely accepted explanation for residual force enhancement (RFE). RFE is the increase in steady-state isometric force following active muscle stretching. The SLNT predicts that active stretching of a
K. Johnston, A. Jinha, W. Herzog
semanticscholar +1 more source
Cytoskeleton, EarlyView.ABSTRACT Cells have an intrinsic ability to rapidly respond to environmental change to regulate cell cycle progression and membrane organisation, thereby affecting cell growth and division. The actin cytoskeleton is a highly dynamic complex of proteins that can rapidly reorganise to change the growth pattern of a cell.
Holly R. Brooker +7 more
wiley +1 more source
The molecular basis for sarcomere organization in vertebrate skeletal muscle
Cell, 2021 Zhexin Wang +5 more
semanticscholar +1 more source
Cytoskeleton, EarlyView.ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos +5 more
wiley +1 more source
Alterations in thin filament length during postnatal skeletal muscle development and aging in mice
Frontiers in Physiology, 2014 The lengths of the sarcomeric thin filaments vary in a skeletal muscle-specific manner and help specify the physiological properties of skeletal muscle.
David S Gokhin +4 more
doaj +1 more source
Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes
Scientific Reports, 2017 RNA-binding protein Rbm24 is a key regulator of heart development and required for sarcomere assembly and heart contractility. Yet, its underlying mechanism remains unclear.
Jing Liu +8 more
semanticscholar +1 more source