Results 161 to 170 of about 42,993 (322)
Measurement and control of mechanics of cardiac trabeculae secured by light‐curable hydrogel
Experimental Physiology, EarlyView.Abstract Isolated cardiac trabeculae are small heart muscle tissue preparations, which have been widely used in in vitro studies of mechanics and energetics function of cardiac muscle. Current instruments for such experimentation often (1) involve delicate mounting of the muscle, (2) constrain investigations to one muscle at a time, and thus (3) limit ...
Emily J. Clark Murphy +6 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu +7 more
wiley +1 more source
Residual force enhancement in myofibrils and sarcomeres
, 2008 Venus Joumaa +2 more
openalex +1 more source
Insights from electromechanical simulations to assess omecamtiv mecarbil efficacy in heart failure
The Journal of Physiology, EarlyView.Abstract figure legend Impact of Omecamtiv Mecarbil (OM) on in‐silico models of heart failure. A mathematical electromechanical model of human ventricular tissue is used to simulate the effects of OM in heart failure with reduced ejection fraction (HFrEF).
Maria Teresa Mora +8 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In this study, we used mathematical modelling to explore the effect of diabetes on muscle mechanoenergetics. Our parameterisation of cross‐bridge models using data from non‐diabetic and diabetic human atrial tissues revealed lower values for cross‐bridge stiffness, detachment rates, attachment rates and lower ATP sensitivity in ...
Julia H. Musgrave +4 more
wiley +1 more source
A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes
The Journal of Physiology, EarlyView.Abstract figure legend 3D cardiomyocyte segmentation enables comprehensive analyses of myocardial microstructure in health and disease; however, it is technically demanding. We present an open‐source toolkit for this task, which reduces challenges associated with sample preparation, image restoration, segmentation and proofreading.
Joachim Greiner +6 more
wiley +1 more source
Computational model of haemodynamics during atrial fibrillation
The Journal of Physiology, EarlyView.Abstract figure legend We developed a simplified computational model that replicates patient‐specific haemodynamics during both normal sinus rhythm and atrial fibrillation (AF). Our computational model comprises: (1) an electrical subsystem that generates unco‐ordinated atrial and irregular ventricular activation times characteristic of AF and (2) a ...
Felix Plappert +7 more
wiley +1 more source
Sarcomere length distribution quantification in whole muscle frozen sections
, 2016 Shawn M. O’Connor +4 more
openalex +2 more sources