Results 251 to 260 of about 65,186 (354)

Conditional Expression of Mutant M-line Titins Results in Cardiomyopathy with Altered Sarcomere Structure [PDF]

, 2003
Michael Gotthardt, Robert E. Hammer, Norbert Hübner, Jan Monti, Christian Witt, Mark McNabb, James A. Richardson, Henk Granzier, Siegfried Labeit, Joachim Herz   +9 more
openalex   +1 more source

Insights from electromechanical simulations to assess omecamtiv mecarbil efficacy in heart failure

The Journal of Physiology, EarlyView.
Abstract figure legend Impact of Omecamtiv Mecarbil (OM) on in‐silico models of heart failure. A mathematical electromechanical model of human ventricular tissue is used to simulate the effects of OM in heart failure with reduced ejection fraction (HFrEF).
Maria Teresa Mora, Ilse van Herck, Cécile Daversin‐Catty, Henrik Finsberg, Jordi Llopis‐Lorente, Javier Saiz, Hermenegild Arevalo, Samuel Wall, Beatriz Trenor   +8 more
wiley   +1 more source

Hamstring Injury Mechanisms and Eccentric Training-Induced Muscle Adaptations: Current Insights and Future Directions. [PDF]

Sports Med
Andrews MH, Shield AJ, Lichtwark GA, Pincheira PA.   +3 more
europepmc   +1 more source

A Novel Variant of Cardiac Myosin-binding Protein-C That Is Unable to Assemble into Sarcomeres Is Expressed in the Aged Mouse Atrium [PDF]

, 2003
Naruki Sato, Tsutomu Kawakami, Ayako Nakayama, Hiroyuki Suzuki, Hideko Kasahara, Takashi Obinata   +5 more
openalex   +1 more source

Metabolite‐sensitive cross‐bridge models of human atria reveal the impact of diabetes on muscle mechanoenergetics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we used mathematical modelling to explore the effect of diabetes on muscle mechanoenergetics. Our parameterisation of cross‐bridge models using data from non‐diabetic and diabetic human atrial tissues revealed lower values for cross‐bridge stiffness, detachment rates, attachment rates and lower ATP sensitivity in ...
Julia H. Musgrave, June‐Chiew Han, Marie‐Louise Ward, Andrew J. Taberner, Kenneth Tran   +4 more
wiley   +1 more source

Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes. [PDF]

Elife
Valencia DA, Koeberlein AN, Nakano H, Rudas A, Patel AA, Harui A, Spencer C, Nakano A, Quinlan ME.   +8 more
europepmc   +1 more source

Restoration of Resting Sarcomere Length After Uniaxial Static Strain Is Regulated by Protein Kinase Cε and Focal Adhesion Kinase [PDF]

, 2004
Haytham Mansour, Pieter P. de Tombe, Allen M. Samarel, Brenda Russell   +3 more
openalex   +1 more source

A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend 3D cardiomyocyte segmentation enables comprehensive analyses of myocardial microstructure in health and disease; however, it is technically demanding. We present an open‐source toolkit for this task, which reduces challenges associated with sample preparation, image restoration, segmentation and proofreading.
Joachim Greiner, Fabio Frangiamore, Frédéric Sonak, Josef Madl, Thomas Seidel, Peter Kohl, Eva A. Rog‐Zielinska   +6 more
wiley   +1 more source

An Exogenous NO Donor Provokes Mechanical Alternans in Normal Rat Atria and Impairs Sarcomere Contractility in Right Atrial Cardiomyocytes in Atrial Fibrillation. [PDF]

Biomolecules
Butova X, Myachina T, Mikhryakova P, Simonova R, Shchepkin D, Khokhlova A.   +5 more
europepmc   +1 more source

Sarcomere Number Regulation Maintained After Immobilization In Desmin-Null Mouse Skeletal Muscle

, 2001
Sameer B. Shah, David G. Peters, Kimberly A. Jordan, Derek J. Milner, Jan Fridén, Yassemi Capetanaki, Richard L. Lieber   +6 more
openalex   +1 more source