Results 141 to 150 of about 19,099 (312)

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Axial muscle‐fibre orientations in larval zebrafish

Journal of Anatomy, Volume 246, Issue 4, Page 517-533, April 2025.
In 4 days post‐fertilization zebrafish larvae, the fast axial muscle fibres follow helical trajectories that taper towards the tail. Adjacent muscle fibres form substantial angles relative to each other to accommodate this pattern. Using a novel semi‐automatic method, we quantified 3D fibre angles over the whole muscle volume.
Noraly M. M. E. van Meer, Johan L. van Leeuwen, Henk Schipper, Martin J. Lankheet   +3 more
wiley   +1 more source

Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function

Communications Biology
UNC-89 is a giant sarcomeric M-line protein required for sarcomere organization and optimal muscle function. UNC-89 contains two protein kinase domains, PK1 and PK2, separated by an elastic region.
Yohei Matsunaga, Hiroshi Qadota, Nasab Ghazal, Leila Lesanpezeshki, Till Dorendorf, Jasmine C. Moody, Arnaud Ahier, Courtney J. Matheny, Siva A. Vanapalli, Steven Zuryn, Olga Mayans, Jennifer Q. Kwong, Guy M. Benian   +12 more
doaj   +1 more source

Adaptation of physiological cross-sectional area and serial number of sarcomeres after tendon transfer of rat muscle

, 2016
Tendon transfer surgery to a new extensor insertion was performed for musculus flexor carpi ulnaris (FCU) of young adult rats, after which animals were allowed to recover.
Maas, H., Huijing, P.A.J.B.M., Maas, H.; id_orcid   +2 more
core   +1 more source

Atrial cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 727-729, April 2025.
Wojciech Kosmala, Monika Przewłocka‐Kosmala   +1 more
wiley   +1 more source

Scratching beneath the surface: Quantification of muscle architecture and myosin heavy chain content in the forelimbs of black‐tailed prairie dogs (Cynomys, Rodentia)

Journal of Anatomy, EarlyView.
Black‐tailed prairie dogs are highly social ground squirrels that excavate communal burrow systems, most often in medium‐textured soils. Their forelimbs demonstrate morphofunctional trade‐offs for scratch‐digging and terrestrial ecology, including well‐developed and fast‐contracting proximal musculature with large mechanical advantage paired with ...
Luke A. Scheetz, Carter A. Burnett, Benjamin R. Kimble, David A. Eads, Michael T. Butcher   +4 more
wiley   +1 more source

Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy

, 2013
Familial hypertrophic cardiomyopathy (HCM), frequently caused by sarcomeric gene mutations, is characterized by cellular dysfunction and asymmetric left-ventricular (LV) hypertrophy.
Heymans, Stephane, van der Velden, Jolanda, Hazebroek, Mark, ten Cate, Folkert J., dos Remedios, Cris, Stam, Kelly, Scellini, Beatrice, Tesi, Chiara, Niessen, Hans W. M., Witjas-Paalberends, E. Rosalie, Michels, Michelle, Ferrara, Claudia, Piroddi, Nicoletta, van Dijk, Sabine J., van Slegtenhorst, Marjon, Stienen, Ger J. M., Oliviera, Vasco Sequeira, Poggesi, Corrado   +17 more
core   +1 more source

Sarcomere length in the beating heart: Synchronicity is optional [PDF]

, 2022
Michiel Helmes, Bradley M. Palmer
openalex   +1 more source

Plasmatic Profiling of Individuals With Combinations of Type 2 Diabetes Mellitus, Dyslipidemia and Periodontitis: A Cross‐Sectional Study

Oral Diseases, EarlyView.
ABSTRACT Aim The objective of this study was to investigate the global profile of plasmatic proteins of individuals affected simultaneously or not by type 2 diabetes mellitus (T2DM, well/poorly‐controlled), Dyslipidemia (DL), and Periodontitis (P). Methods Besides periodontal examination, plasma was collected for glycemic, and lipid analyses from 150 ...
François Isnaldo Dias Caldeira, Sâmia Cruz Tfaile Corbi, Alliny de Souza Bastos, Silvana Regina Perez Orrico, Cristiane Ribeiro Salmon, Yizhi Xiao, Walter Luiz Siqueira, Raquel Mantuaneli Scarel‐Caminaga   +7 more
wiley   +1 more source

Titin-dependent biomechanical feedback tailors sarcomeres to specialised muscle functions in insects

Sarcomeres are the contractile units of muscles that enable animals to move. Insect muscles are remarkable examples because they use extremely different contraction frequencies (ranging from ∼1 to 1000 Hz) and amplitudes for flying, walking and crawling.
de Boissier, Paul, Rupprecht, Jean-François, Avosani, Sabina, Sane, Aditya, Chan, Eunice, Hoyee, Habermann, Bianca, H, Görlich, Dirk, Mangeol, Pierre, Brouilly, Nicolas, von Philipsborn, Anne, C, Schnorrer, Frank, Loreau, Vincent, Pitaval, Christophe, Luis, Nuno, Miguel, Koolhaas, Wouter, Reiter, Stefanie   +15 more
core   +1 more source