Results 141 to 150 of about 30,048 (267)

Ageing alters cysteine oxidation‐regulated redox signalling in skeletal muscle: Integrative omics and AI‐based structural predictions

Experimental Physiology, EarlyView.
Abstract Ageing is associated with loss of skeletal muscle mass and strength (sarcopenia) and disrupted redox homeostasis. Redox signalling is essential for muscle adaptation, yet the mechanisms by which ageing disrupts cysteine‐based regulation are poorly defined. The drivers of site‐specific reactivity and signalling specificity in aged muscle remain
Ufuk Ersoy, Malcolm J. Jackson
wiley   +1 more source

Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation. [PDF]

J Biol Chem
Pricolo MR, López-Unzu MA, Vicente N, Morales-López C, Huerta-López C, Pérez-Franco W, Dumitru AC, Peña-Peña J, Espinosa FM, Sanchez MI, Garcia R, Silva-Rojas R, Torres M, Herrero-Galán E, Alegre-Cebollada J.   +14 more
europepmc   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy.

Cardiovascular Research, 2013
E. R. Witjas-Paalberends, N. Piroddi, K. Stam, S. Dijk, V. Oliviera, C. Ferrara, B. Scellini, M. Hazebroek, F. J. Cate, M. V. Slegtenhorst, Cristobal G. dos Remedios, H. Niessen, C. Tesi, G. Stienen, G. Stienen, S. Heymans, M. Michels, C. Poggesi, J. Velden   +18 more
semanticscholar   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source

Generation of a functional fluorescently-tagged PFN-3 profilin transgene in <i>Caenorhabditis elegans</i>. [PDF]

MicroPubl Biol
Kimmich M, Pruyne D.
europepmc   +1 more source

The mechanisms of the residual force enhancement after stretch of skeletal muscle: non-uniformity in half-sarcomeres and stiffness of titin

Proceedings of the Royal Society of London. Biological Sciences, 2012
D. Rassier
semanticscholar   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Myosin folding boosts solubility in cardiac muscle sarcomeres

JCI Insight
The polymerization of myosin molecules into thick filaments in muscle sarcomeres is essential for cardiac contractility, with the attenuation of interactions between the heads of myosin molecules within the filaments being proposed to result in ...
Colleen M. Kelly, Jody L. Martin, Michael J. Previs   +2 more
doaj   +1 more source