Results 201 to 210 of about 16,570 (272)

Rho-Kinase Inhibition Attenuates Elevated Myofilament Ca2+ Sensitivity and Improves Sarcomere Function in Salt-Sensitive Prediabetic Rats

James T. Pearson, Mark T. Waddingham, Melissa Herwig, Marcel Sieme, Kohki Aoyama, Vijayakumar Sukumaran, Tadakatsu Inagaki, Naoki Tokuhara, Takashi Sonobe, Hirotsugu Tsuchimochi, Mikiyasu Shirai, Nazha Hamdani   +11 more
openalex   +1 more source

Lesion Formation in Cardiac Pulsed‐Field Ablation: Acute to Chronic Cellular Level Changes

Pacing and Clinical Electrophysiology, Volume 49, Issue 1, Page 32-42, January 2026.
ABSTRACT As pulsed‐field ablation (PFA) emerges as a promising therapy for atrial arrhythmias, an understanding of the cellular injury to cardiac tissue is critical to evaluating and interpreting results for each PFA system. This review aims to detail the mechanism of cell death for PFA, compare the cell death mechanism to thermal ablation modalities ...
Kara Garrott, Savannah Bifulco, David Ramirez, Brendan Koop   +3 more
wiley   +1 more source

Alpha-actinin-1 promotes adhesion maturation and facilitates sarcomere assembly in cardiac myocytes. [PDF]

Mol Biol Cell
Hayes JB, Bainbridge AM, Willet AH, Burnette DT.   +3 more
europepmc   +1 more source

Aldehyde Dehydrogenase‐2 Alleviates Septic Myocardial Injury by Inhibiting Caspase‐11‐Mediated Noncanonical Pyroptosis

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Purpose The purpose of this study is to investigate the role of aldehyde dehydrogenase‐2 (ALDH2) in septic myocardial injury, focusing on noncanonical pyroptosis. Methods In vivo, C57BL/6J mice were divided into five groups: Sham, cecal ligation and puncture (CLP), CLP + Alda‐1 (ALDH2 agonist), Sham + dimethyl sulfoxide (DMSO, solvent control), and CLP 
Huan Liang, Yuying He, Yiren Wang, Rui Zhang, Mengjie Yu, Hongwei Ye, JiaHui Wang, Qin Gao, Vivek Pandey   +8 more
wiley   +1 more source

Popping the hood of muscle motors using time-resolved, small-angle X-ray diffraction. [PDF]

Proc Natl Acad Sci U S A
Hessel AL.
europepmc   +1 more source

Low‐Dose Mavacamten Initiation in Obstructive Hypertrophic Cardiomyopathy: A Real‐World Study in China

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Aims To evaluate the real‐world efficacy and safety of low‐dose (2.5 mg) mavacamten initiation in Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). Methods and Results This single‐center observational study (Zhongshan Hospital, China; Oct 2024–Apr 2025) enrolled 72 symptomatic oHCM patients (NYHA II/III, LVEF ≥ 55 ...
Wenlong Yang, Hui Shi, Rebecca Suchi Chang, Yin Zhang, A. Jixiang, Chunyu Wu, Juying Qian, Junbo Ge, Shuning Zhang, Baohui Xu   +9 more
wiley   +1 more source

Simulation of Ca2+ Release from the Sarcoplasmic Reticulum with Three-Dimensional Sarcomere Model in Cardiac Muscle.

, 2002
Tsukasa Tameyasu
openalex   +2 more sources

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy

Physiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri, Seitaro Nomura, Takafumi Nakajima, Hironobu Kikuchi, Syotaro Obi, Issei Komuro, Norihiko Takeda, Shigeru Toyoda, Toshiaki Nakajima   +8 more
wiley   +1 more source

The varied functions of the giant muscle scaffold protein obscurin. [PDF]

Front Cell Dev Biol
Di Paola JN, Schöck F.
europepmc   +1 more source

Omega‐3 fatty acid supplementation does not attenuate declines in skeletal muscle mitochondrial area in young, healthy females during immobilization

Physiological Reports, Volume 14, Issue 2, January 2026.
Abstract Mitochondrial subcellular area influences function. Muscle disuse reduces mitochondrial content; however, its effect on mitochondrial subcellular location is unclear. Omega‐3 fatty acid (n‐3) attenuates declines in muscle mass and mitochondrial function during disuse; however, whether n‐3 supplementation prevents the decline in mitochondrial ...
Megan M. Lo, Merryl N. Black, Chris McGlory, Ravninder Bahniwal, Michael Kamal, Joe Quadrilatero, Stuart M. Phillips, Michaela C. Devries   +7 more
wiley   +1 more source