Results 91 to 100 of about 79,406 (256)

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

A proposed role for non-junctional transverse tubules in skeletal muscle as flexible segments allowing expansion of the transverse network

European Journal of Translational Myology, 2019
Using a variety of technical approaches, we have detected the presence of continuous triads that cover the entire length of T tubules in the main white body muscles of several small fish.
Manuela Lavorato, Ramesh Iyer, Clara Franzini-Armstrong   +2 more
doaj   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. [PDF]

, 2019
Biological roles of obscurin and its close homolog Obsl1 (obscurin-like 1) have been enigmatic. While obscurin is highly expressed in striated muscles, Obsl1 is found ubiquitously.
Blondelle, Jordan, Bremner, Shannon, Clark, Madison, Desmond, Patrick, Estève, Eric, Ghassemian, Majid, Lange, Stephan, Marrocco, Valeria, Myers, Stephanie, Nguyen, Jim, Pierantozzi, Enrico, Sorrentino, Vincenzo, Ward, Samuel, Wright, Matthew   +13 more
core   +1 more source

A quad‐cistronic fluorescent biosensor system for real‐time detection of subcellular Ca2+ signals

British Journal of Pharmacology, EarlyView.
Background and Purpose The calcium ion (Ca2+) is a versatile cellular messenger regulating a variety of biological processes. Compounds modulating subcellular Ca2+ signals hold substantial pharmacological potential. Advances in fluorescent biosensors have revolutionised Ca2+ imaging.
Anna Lischnig, Yusuf C. Erdoğan, Benjamin Gottschalk, Michael Gruber, Andrea Groselj‐Strele, Sandra Burgstaller, Wolfgang F. Graier, Roland Malli   +7 more
wiley   +1 more source

Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans [PDF]

, 2013
Cardiac alternansis an important risk factor in cardiac physiology, and is related to the initiation of many pathophysiological conditions. However, the mechanisms underlying the generation of alternans remain unclear. In this study, we used a population
Bueno-Orovio, A., Burrage, K., Hanson, B., Haywood, M., Lambiase, P., Orini, M., Rodriguez, B., Taggart, P., Zhou, X.   +8 more
core  

Intrinsic aerobic capacity sets a divide for aging and longevity [PDF]

, 2011
<p><b>Rationale:</b> Low aerobic exercise capacity is a powerful predictor of premature morbidity and mortality for healthy adults as well as those with cardiovascular disease.
Charles F. Burant, Elizabeth M. van Grevenhof, Godfrey L. Smith, Helene Wisløff, John E. Wilkinson, Lauren Gerard Koch, Lori J. Gilligan, Morten A. Høydal, Natale Rolim, Nathan Qi, Ole J. Kemi, Peter M. Abadir, Piter Bijma, Sean X. Leng, Steven L. Britton, Tosato M, Ulrik Wisløff, Øyvind Ellingsen   +17 more
core   +3 more sources

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Sex Differences with Aging in the Fatigability of Dynamic Contractions [PDF]

, 2015
This study determined the sex difference with aging in fatigability of the elbow flexor muscles during a dynamic fatiguing task, and explored the associated mechanisms.
Doyel, Ryan E., Hunter, Sandra K., Widule, Claire, Yoon, Tejin   +3 more
core   +2 more sources

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source