Results 71 to 80 of about 42,516 (245)
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Locomotion consumes a large proportion of individual energy budgets and may impose energetic constraints on other fitness‐related traits particularly under variable environmental conditions.
Miki Jahn, Frank Seebacher
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Andrology, EarlyView.ABSTRACT Background Spontaneous phasic contractions (SPCs) in the epididymal duct play an important role in transport and maturation of sperm. In proximal cauda of the rat epididymis, platelet‐derived growth factor receptor α (PDGFRα)‐positive smooth muscle cells (SMCs) generate ANO1 Ca2+‐activated chloride channels (CaCCs)‐dependent spontaneous ...
Wataru Kudo +5 more
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Redox regulation of calcium release in skeletal and cardiac muscle
Biological Research, 2002 In skeletal and cardiac muscle cells, specific isoforms of the Ryanodine receptor channels mediate Ca2+ release from the sarcoplasmic reticulum. These channels are highly susceptible to redox modifications, which regulate channel activity.
CECILIA HIDALGO +3 more
doaj
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
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Nature CommunicationsCalmodulin transduces [Ca2+] information regulating the rhythmic Ca2+ cycling between the sarcoplasmic reticulum and cytoplasm during contraction and relaxation in cardiac and skeletal muscle.
Robyn T. Rebbeck +6 more
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A quad‐cistronic fluorescent biosensor system for real‐time detection of subcellular Ca2+ signals
British Journal of Pharmacology, EarlyView.Background and Purpose The calcium ion (Ca2+) is a versatile cellular messenger regulating a variety of biological processes. Compounds modulating subcellular Ca2+ signals hold substantial pharmacological potential. Advances in fluorescent biosensors have revolutionised Ca2+ imaging.
Anna Lischnig +7 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder +7 more
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The Ultrastructure of Developing Sarcoplasmic Reticulum
Journal of Biological Chemistry, 1974 Developmental changes in the sarcoplasmic reticulum and surface membranes of chicken skeletal muscles were investigated by electron microscopy. A dominant feature of freeze-etched sarcoplasmic reticulum membranes isolated from adult animals is the presence of spherical intramembranous particles of 75 A apparent diameter which are more numerous on the ...
T W, Tillack, R, Boland, A, Martonosi
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Bruton tyrosine kinase inhibitors and cardiovascular adverse events
British Journal of Pharmacology, EarlyView.Abstract Bruton tyrosine kinase inhibitors (BTKi) have transformed the management of chronic lymphocytic leukaemia and other B‐cell malignancies, yet their therapeutic benefit is tempered by clinically relevant cardiovascular toxicities (predominantly atrial fibrillation, hypertension, bleeding and ventricular arrhythmias).
Massimiliano Camilli +4 more
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