Results 101 to 110 of about 79,406 (256)

Redox regulation of calcium release in skeletal and cardiac muscle

open access: yesBiological Research, 2002
In skeletal and cardiac muscle cells, specific isoforms of the Ryanodine receptor channels mediate Ca2+ release from the sarcoplasmic reticulum. These channels are highly susceptible to redox modifications, which regulate channel activity.
CECILIA HIDALGO   +3 more
doaj  

Foot protein isoforms are expressed at different times during embryonic chick skeletal muscle development. [PDF]

open access: yes, 1991
We have investigated the time course of expression of the alpha and beta triad junctional foot proteins in embryonic chick pectoral muscle. The level of [3H]ryanodine binding in muscle homogenates is low until day E20 of embryonic development, then ...
Airey, JA   +6 more
core   +1 more source

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili   +16 more
wiley   +1 more source

Kinetics and mapping of Ca-driven calmodulin conformations on skeletal and cardiac muscle ryanodine receptors

open access: yesNature Communications
Calmodulin transduces [Ca2+] information regulating the rhythmic Ca2+ cycling between the sarcoplasmic reticulum and cytoplasm during contraction and relaxation in cardiac and skeletal muscle.
Robyn T. Rebbeck   +6 more
doaj   +1 more source

Fine structure of the cardiac muscle cells in the orb-web spider Nephila clavata

open access: yesApplied Microscopy, 2020
The fine structural characteristics of cardiac muscle cells and its myofibril organization in the orb web spider N. clavata were examined by transmission electron microscopy.
Yan Sun, Hyo-Jeong Kim, Myung-Jin Moon
doaj   +1 more source

Initial neuromuscular performance in older women influences response to explosive resistance training [PDF]

open access: yes, 2009
The purpose of the study was to identify both demographic and neuromuscular traits that characterize successful or unsuccessful adaptation to resistance training in older women.
LaRoche, Dain P.
core   +1 more source

Cardiac hypertrophy and heart failure: from the case to review of literature [PDF]

open access: yes, 2016
In response to an increased workload due to physiological or pathological stimuli, the heart may undergo a process of growth with increased muscle mass called cardiac hypertrophy. It is a particular mechanism of long term compensation used by the heart
Massoni, Francesco   +4 more
core   +1 more source

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

open access: yesCell Proliferation, EarlyView.
The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao   +6 more
wiley   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

open access: yesThe FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna   +5 more
wiley   +1 more source

Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice [PDF]

open access: yes, 2013
Muscle strength declines with age in part due to a decline of Ca(2+) release from sarcoplasmic reticulum calcium stores. Skeletal muscle dihydropyridine receptors (Ca(v)1.1) initiate muscle contraction by activating ryanodine receptors in the ...
Bergamelli, Leda   +14 more
core   +2 more sources

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