Pulmonary Circulation, 2021 Upon sensing a reduction in local oxygen partial pressure, pulmonary vessels constrict, a phenomenon known as hypoxic pulmonary vasoconstriction. Excessive hypoxic pulmonary vasoconstriction can occur with ascent to high altitude and is a contributing ...
Larissa A. Shimoda +6 more
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Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes. [PDF]
, 2020 Excitation-contraction (EC) coupling is the coordinated process by which an action potential triggers cardiac myocyte contraction. EC coupling is initiated in dyads where the junctional sarcoplasmic reticulum (jSR) is in tight proximity to the sarcolemma
de la Mata, Ana +5 more
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Waves of calcium depletion in the sarcoplasmic reticulum of vascular smooth muscle cells: an inside view of spatiotemporal Ca2+ regulation. [PDF]
PLoS ONE, 2013 Agonist-stimulated smooth muscle Ca2+ waves regulate blood vessel tone and vasomotion. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were stimulated by a combination of inositol 1,4,5-trisphosphate- and Ca2 ...
Mitra Esfandiarei +5 more
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Calsequestrins in skeletal and cardiac muscle from adult Danio rerio [PDF]
, 2015 Calsequestrin (Casq) is a high capacity, low affinity Ca2+-binding protein, critical for Ca2+-buffering in cardiac and skeletal muscle sarcoplasmic reticulum. All vertebrates have multiple genes encoding for different Casq isoforms.
Argenton, Francesco +6 more
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Aluminum chloride effect on Ca(2+),Mg(2+)-ATPase activity and dynamic parameters of skeletal muscle contraction [PDF]
The Ukrainian Biochemical Journal, 2015 We studied enzymatic activity and measured strain-gauge contraction properties of the frog Rana temporaria m. tibialis anterior muscle fascicles during the action of aluminum chloride solution. It was shown that AlCl3 solutions did not affect the dynamic
D. M. Nozdrenko +3 more
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Mitochondrial and Sarcoplasmic Reticulum Interconnection in Cardiac Arrhythmia
Frontiers in Cell and Developmental Biology, 2021 Ca2+ plays a pivotal role in mitochondrial energy production, contraction, and apoptosis. Mitochondrial Ca2+-targeted fluorescent probes have demonstrated that mitochondria Ca2+ transients are synchronized with Ca2+ fluxes occurring in the sarcoplasmic ...
Felipe Salazar-Ramírez +5 more
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Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure [PDF]
, 2018 Aims: Cellular processes in the heart rely mainly on studies from experimental animal models or explanted hearts from patients with terminal end-stage heart failure (HF).
Condorelli, Gianluigi +12 more
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Interval training normalizes cCardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy [PDF]
, 2009 In the present study we explored the mechanisms behind excitation-contraction (EC)-coupling defects in cardiomyocytes from mice with type-2 diabetes (db/db), and determined whether 13-weeks of aerobic interval training could restore cardiomyocyte Ca2 ...
Aasum, E. +10 more
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Role of sarcoplasmic reticulum phospholipids in calcium ion binding activity
Journal of Lipid Research, 1974 The relationship between sarcoplasmic reticulum phospholipid and Ca2+ binding by sarcoplasmic reticulum membraneswas explored. Ca2+ bound in the absence of ATP was defined as “ATP-independent Ca2+ binding,” and the additional amount of Ca2+ bound in the ...
Joel Steinberg +2 more
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The impact of ovariectomy on calcium homeostasis and myofilament calcium sensitivity in the aging mouse heart. [PDF]
PLoS ONE, 2013 This study determined whether deficiency of ovarian estrogen starting very early in life promoted age-associated Ca(2+) dysregulation and contractile dysfunction in isolated ventricular myocytes.
Elias Fares +6 more
doaj +1 more source