Results 231 to 240 of about 79,406 (256)

Suppression of premature ventricular complexes with the PDE5 inhibitor sildenafil: First clinical experience

Experimental Physiology, Volume 111, Issue 3, Page 625-631, 1 March 2026.
Abstract The phosphodiesterase‐5 inhibitor sildenafil suppresses ventricular arrhythmias in a sheep model of drug‐induced long QT. In that study, ventricular arrhythmias were abolished by reducing premature ventricular complexes (PVCs) and delaying PVC onset, thus preventing ‘R‐on‐T’ ventricular tachycardia.
David C. Hutchings, Christopher P. Denton, Luigi Venetucci, Andrew W. Trafford   +3 more
wiley   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, Volume 111, Issue 3, Page 653-673, 1 March 2026.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

A model of β‐adrenergic stimulation in human ventricular cells for tissue‐scale simulations of sympathetically modulated tachycardias

The Journal of Physiology, Volume 604, Issue 5, Page 1897-1914, 1 March 2026.
Abstract figure legend Modelling β‐adrenergic stimulation in sympathetically remodelled ventricular substrates. Myocardial infarction could result in sympathetic remodelling in ventricular tissues, which affects arrhythmia dynamics. However sympathetic remodelling is challenging to control experimentally; therefore we created an ionic model that ...
Kelly Zhang, Karl Magtibay, Natalia Trayanova, Edward Vigmond   +3 more
wiley   +1 more source

Cardiotropic Gene Therapy for Heart Failure: Translational Lessons From AB‐1002

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
Nghia Phu Nguyen, Phillip Tran
wiley   +1 more source

Selective RyR2 inhibition reduces arrhythmia susceptibility in human cardiac slices

The Journal of Physiology, Volume 604, Issue 5, Page 1809-1819, 1 March 2026.
Abstract figure legend ent‐Vert selectively inhibits RyR2‐mediated sarcoplasmic reticulum (SR) Ca2+ leak and prevents triggered activity in human cardiac slices. A, in human ventricular slices exposed to β‐adrenergic stimulation with Iso and RyR2 sensitization with caffeine, RyR2 channels become hyperactive, leading to Ca2+ sarcoplasmic leak and ...
Micah K. Madrid, Katy A. Trampel, Batool Salman, Sharon A. George, Tatiana Efimova, Bjorn Knollmann, Igor R. Efimov   +6 more
wiley   +1 more source

Sildenafil helps the beat go on

Experimental Physiology, Volume 111, Issue 3, Page 596-597, 1 March 2026.
Jules C. Hancox
wiley   +1 more source

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