Results 21 to 30 of about 79,406 (256)
SERCA is critical to control the Bowditch effect in the heart [PDF]
, 2018 The Bowditch effect or staircase phenomenon is the increment or reduction of contractile force when heart rate increases, defined as either a positive or negative staircase.
Balcazar, Dario Emmanuel +6 more
core +2 more sources
Journal of Pharmacological Sciences, 2013 Developmental changes in excitation–contraction mechanisms were examined in the ventricular myocardium from fetal, neonatal, and 1-, 2-, and 4-week-old mice.
Shogo Hamaguchi +6 more
doaj +1 more source
Impact of an electric field on P-type ATPases [PDF]
, 2008 P-type ATPases are membrane proteins acting as ion pumps that drive an active transport of cations across the membrane against a concentration gradient. The required energy for the ion transport is provided by binding and hydrolysis of ATP.
Hauser, Karin, Weidemüller, Christian
core +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Mitochondrial dysfunction contributes to the cardiac remodeling triggered by type 2 diabetes (T2D). Mitochondrial Ca2+ concentration ([Ca2+]m) modulates the oxidative state and cytosolic Ca2+ regulation.
Sathya Velmurugan +5 more
doaj +1 more source
Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM
Nature Communications, 2021 Ryanodine Receptors (RyRs) release Ca2+ from the endoplasmic and sarcoplasmic reticulum. Mutations in RyR are linked to malignant hyperthermia (MH), myopathies, and arrhythmias. Here, a collection of cryoEM structures provides insights into the molecular
Kellie A. Woll +2 more
doaj +1 more source
Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]
, 2008 Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Bergner, Albrecht +6 more
core +1 more source
Scientific Reports, 2017 GTP cyclohydrolase 1 (GCH1) and its product tetrahydrobiopterin play crucial roles in cardiovascular health and disease, yet the exact regulation and role of GCH1 in adverse cardiac remodeling after myocardial infarction are still enigmatic.
Yanan Liu +10 more
doaj +1 more source
The Components and Boundaries of Mechanisms [PDF]
, 2017 Mechanisms are said to consist of two kinds of components, entities and activities. In the first half of this chapter, I examine what entities and activities are, how they relate to well-known ontological categories, such as processes or dispositions ...
Kaiser, Marie I.
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European Journal of Translational Myology, 2016 Rabbit muscle vesicles derived from sarcoplasmic reticulum were used as a material in studying networks of ryanodine receptors by cryo electron tomography. Three-dimensional analysis reveals the dynamical features of these networks. It was found that the
Hongli Hu, Xing Meng
doaj +1 more source
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis [PDF]
, 2019 Aims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying electrophysiological alterations hampers ...
Benítez Iglesias, Raúl +9 more
core +2 more sources