Sarin poisoning of a rescue team in the Matsumoto sarin incident in Japan. [PDF]
Occupational and Environmental Medicine, 1997 OBJECTIVES: A nerve agent sarin (isopropyl methyl phosphonofluoridate) was released in Matsumoto city, Japan, on 27 June 1994. About 600 people were affected by the sarin, including seven who died. Fifty two rescuers engaged in helping the victims and 18 were affected. The aim was to investigate how the rescuers were affected by sarin.
Tamie Nakajima +3 more
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The Impairment of Spatial Memory Following Low-Level Sarin Inhalation Exposure and Antidotal Treatment in Rats [PDF]
Acta Medica, 2002 1. To study the influence of antidotes on low-level sarin-induced impairment of cognitive functions, the rats were exposed to three various low concentrations of sarin (LEVEL 1–3) for 60 minutes in the inhalation chamber.
Jiří Kassa +2 more
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The Long Term Changes in Liver DNA and Total Protein Contents Following Low Level Sarin Exposure in Rats [PDF]
Acta Medica, 2000 1. The changes in contents of DNA and total protein in the liver of the rats exposed to low level sarin by inhalation at 3, 6 and 12 months following the exposure were studied.
Jiří Kassa +2 more
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Refractoriness (Tachyphylaxis) to ‘Sarin’ [PDF]
Nature, 1962 APART from experiments reported in 1954 by Barnes and Duff1, the occurrence of tachyphylaxis to poisons which act by inhibiting cholinesterase has been little publicized, although the phenomenon appears to offer possibilities as a means of investigating cholinergic function. The following is an account of a method which, in a proportion of experiments,
C. A. deCandole
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Cyclopentolate in treatment of sarin miosis [PDF]
British Journal of Pharmacology, 1973 Summary . Six young male volunteers were exposed to sarin vapour (isopropyl methyl phosphonofluoridate) at a concentration of 0·5 mg/m3 for 30 min (concentration time (Ct) 15 (mg min)/m3). . The resulting clinical syndrome was treated by instilling 0·06 ml of a 1% solution of cyclopentolate into the conjunctival sac. .
R. J. MOYLAN‐JONES, D. Price Thomas
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Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures [PDF]
Journal of Neuroinflammation, 2011 Background Organophosphorus nerve agents irreversibly inhibit acetylcholinesterase, causing a toxic buildup of acetylcholine at muscarinic and nicotinic receptors.
Meyerhoff James L +4 more
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Inhalation Apparatus for Generating Sarin and Soman Toxic Vapors
Acta Medica, 2003 The developed inhalation system is a dynamic and whole-body exposure model designated for generating sarin or soman vapors. It consists of an evaporating apparatus, an inhalation chamber and a carbon filter.
Lucie Ševelová +2 more
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Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin [PDF]
Journal of Neuroinflammation, 2011 Background Although the acute toxicity of organophosphorus nerve agents is known to result from acetylcholinesterase inhibition, the molecular mechanisms involved in the development of neuropathology following nerve agent-induced seizure are not well ...
Meyerhoff James L +4 more
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Study on the Degradation Effect of Three Organophosphorus Hydrolase Mutant on Sarin [PDF]
E3S Web of Conferences, 2021 Organophosphorus hydrolase can effectively degrade organic phosphorus compounds such as sarin. In this study, we constructed a recombinant Bacillus subtilis mutant expressing organophosphorus hydrolase, measured the effect of the mutant on the ...
Gu Qiamin +4 more
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