The benefit of combinations of oximes for the ability of antidotal treatment to counteract sarin-induced brain damage in rats [PDF]
BMC Pharmacology and Toxicology, 2018 Background The aim of our study was to compare the ability of two combinations of oximes (HI-6 + trimedoxime and HI-6 + K203) with atropine to counteract acute sarin-induced brain damage with the efficacy of antidotal treatment involving single oxime (HI-
Filip Caisberger +5 more
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Long Term Alteration of Immune Functions Following Low Level Exposure to Sarin in Rats [PDF]
Acta Medica, 2000 1. Long term alteration of immune functions caused by low doses of nerve agent sarin were studied in rats exposed to sarin by inhalation. The alteration of immune functions by sarin was monitored by using two methods (the evaluation of in vitro ...
Jiří Kassa +2 more
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Inhalation Apparatus for Generating Sarin and Soman Toxic Vapors [PDF]
Acta Medica, 2003 The developed inhalation system is a dynamic and whole-body exposure model designated for generating sarin or soman vapors. It consists of an evaporating apparatus, an inhalation chamber and a carbon filter.
Lucie Ševelová +2 more
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Вестник войск РХБ защиты, 2023 Sarin is considered to be an instrument for chemical terror by the extremist organizations due to the availability of technologies and components for its production.
V. А. Ignatyev +3 more
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Ultra-Sensitive Analysis of Organophosphorus Compounds by Comparative GC-FPD and GC-ICP-MS: Implications for Chemical Warfare Agent Detection [PDF]
MoleculesOrganophosphorus chemical warfare agents such as sarin (GB), soman (GD), and cyclosarin (GF) rank among the most toxic substances known, making trace-level detection critical for public and military safety.
Michał Wiktorko +5 more
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Journal of Neuroinflammation, 2011 Background Organophosphorus nerve agents irreversibly inhibit acetylcholinesterase, causing a toxic buildup of acetylcholine at muscarinic and nicotinic receptors.
Meyerhoff James L +4 more
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Impact of antidote quantity, timing and prehospital strategies in nerve agent mass casualty events: a simulation study [PDF]
Frontiers in Public HealthIntroductionMass casualty incidents (MCIs) involving nerve agents pose major challenges for emergency medical response due to rapid symptom onset, hazardous environments, and operational uncertainties.
Ruben De Rouck +6 more
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Study on the Degradation Effect of Three Organophosphorus Hydrolase Mutant on Sarin [PDF]
E3S Web of Conferences, 2021 Organophosphorus hydrolase can effectively degrade organic phosphorus compounds such as sarin. In this study, we constructed a recombinant Bacillus subtilis mutant expressing organophosphorus hydrolase, measured the effect of the mutant on the ...
Gu Qiamin +4 more
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Fatal sarin poisoning in Syria 2013: forensic verification within an international laboratory network [PDF]
Forensic Toxicology, 2017 Harald John, Franz Worek, Daan Noort
exaly +2 more sources
Biology, 2023 Sarin is a potent organophosphorus nerve agent that causes cognitive dysfunction, but its underlying molecular mechanisms are poorly understood. In this study, a rat model of repeated low-level sarin exposure was established using the subcutaneous ...
Jingjing Shi +10 more
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