Results 1 to 10 of about 611 (156)

The Structural Basis of Binding Stability and Selectivity of Sarolaner Enantiomers for Ctenocephalides felis RDL Receptors [PDF]

Molecules
The ionotropic γ-aminobutyric acid (GABA) receptor (GABAR) is a key target for the development of antiparasitic agents, particularly against ectoparasites, such as fleas and ticks.
Xiaojiao Zheng, Xin Wang, Xiulian Ju, Zhichao Ma, Genyan Liu   +4 more
doaj   +5 more sources

Efficacy of sarolaner in Simparica® (sarolaner) chewables and Simparica Trio® (sarolaner, moxidectin, and pyrantel chewable tablets) against two US strains of Haemaphysalis longicornis [PDF]

Parasites & Vectors
Background Haemaphysalis longicornis (Asian longhorned tick) is an invasive species now established in the Northeastern and Mid-Atlantic USA. It feeds on mammalian wildlife, livestock, birds, cats, dogs, and humans. Simparica® and Simparica Trio® contain
Jessica Rodriguez, Shelby Jones, Lucas Taylor, Jody DeMarco, Keith Baker, Melanie Myers   +5 more
doaj   +4 more sources

Comparative speed of kill of induced Ixodes scapularis infestations following treatment of dogs with endectocides containing either sarolaner (Simparica Trio™), afoxolaner (NexGard® PLUS), or lotilaner (Credelio Quattro™) [PDF]

Parasites & Vectors
Background Ixodes scapularis is a consequential tick species in North America that can transmit multiple pathogens of canine and public health significance. Acaricidal speed is critical for reducing the risk of pathogen transmission.
Kathryn E. Reif, Todd M. Kollasch, Casey L. Locklear, Matthew D. Eberts, Kayla N. Braswell, Anastasia M. W. Cooper, James W. Gillespie, Brian H. Herrin, Jonas P. McAbee, Carter M. Morgan, Anna Grace Morrow, Bailey J. Sperling, Daniel J. Sweeney, William G. Ryan   +13 more
doaj   +3 more sources

A Discrete Choice Experiment to Assess Cat Owners’ Preferences for Topical Antiparasitics and the Comparative Ease of Use of a Combined Selamectin and Sarolaner Formulation: An International Survey [PDF]

Animals
Cat owners are involved in their cats’ healthcare, including the prevention of parasitic diseases. However, a comprehensive understanding of their preferences for feline antiparasitics is lacking.
Constantina N. Tsokana, George Valiakos, Kennedy Mwacalimba, Danielle Riley, Ashley Enstone, Robin Wyn, Tom Metcalf, Emily Melchior, Eleni Pavlidou, Andrea Wright   +9 more
doaj   +3 more sources

Model development to assess the impact of a preventive treatment with sarolaner and moxidectin on Dirofilaria immitis infection dynamics in dogs [PDF]

Parasites & Vectors
Background Dirofilaria immitis is a mosquito-transmitted filarial parasite causing heartworm disease in dogs. The parasite may cause a significant disease burden to the dog population in high prevalence areas and is mainly managed through prophylactic ...
Emilie Hendrickx, Thomas Geurden, Cedric Marsboom   +2 more
doaj   +4 more sources

Efficacy of a spot-on combination product containing selamectin and sarolaner (Stronghold® Plus) in the treatment of naturally occurring Notoedres cati infestations in cats [PDF]

Frontiers in Veterinary Science
Notoedric mange (also known as feline scabies) is a highly contagious and intensely pruritic dermatologic condition of cats caused by infestation with Notoedres cati mites. Previous publications provide evidence that topical selamectin, and more recently,
Stasia Borowski, Helena Berlamont, Thomas Geurden, Lina D’Hanis, Dhimiter Rapti, Dejan Cvejić, Oliver Suckstorff, Nikola Simović, Vickie L. King   +8 more
doaj   +2 more sources

A novel method for the determination of isoxazoline derivatives in plasma by ultra-high performance liquid chromatography–tandem mass spectrometry: validation and applicability to screening tests [PDF]

Journal of Veterinary Research
Isoxazoline derivatives such as fluralaner, sarolaner, lotilaner, and afoxolaner are a new class of insecticide and acaricide compounds. These compounds are characterised by rapid action and high efficacy over a period of up to several weeks.
Markowska-Buńka Paulina, Jaroszewski Jerzy J., Rasiński Bartosz, Ziółkowski Hubert   +3 more
doaj   +2 more sources

Comparative speed of kill provided by lotilaner (Credelio™), sarolaner (Simparica Trio™), and afoxolaner (NexGard™) to control Amblyomma americanum infestations on dogs [PDF]

Parasites & Vectors
Abstract Background Canine acaricides with rapid onset and sustained activity can reduce pathogen transmission risk and enhance pet owner experience.
Kathryn E. Reif, Todd M. Kollasch, Jacqueline C. Neilson, Brian H. Herrin, William G. Ryan, Marjorie C. Bell, Mallory S. Beltz, Michael W. Dryden, Jeba R. J. Jesudoss Chelladurai, Kamilyah R. Miller, Cameron J. Sutherland   +10 more
doaj   +2 more sources

Efficacy of Simparica and Simparica TRIO for the prevention of Borrelia burgdorferi by Ixodes scapularis [PDF]

Parasites & Vectors
Background Both Simparica® and Simparica TRIO® chewable tablets are efficacious within 12 h against existing Ixodes scapularis infestations and within 24 h against re-infestations for 1 month.
Thomas Geurden, Susan Holzmer, Jamie A. E. Myers, Kristina Kryda, Louise Longstaff, Riaan Maree, John W. McCall, Sean Mahabir, Jessica Rodriguez   +8 more
doaj   +2 more sources

Efficacy of Revolution® Plus (selamectin plus sarolaner) against Amblyomma americanum (lone star ticks) in cats [PDF]

Parasites & Vectors
Background The efficacy of a topical combination product, Revolution® Plus, containing selamectin and sarolaner was evaluated for efficacy against Amblyomma americanum ticks in cats.
Susan Holzmer, Adriano F. Vatta, Sara Chapin, Vickie King, Jamie A. E. Myers   +4 more
doaj   +2 more sources