Results 101 to 110 of about 120,121 (346)

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

Advanced Science, EarlyView.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu, Xiyan Liao, Limin Xie, Xiaoxiao Sun, Luodi Jing, Qin Zeng, Hongwei Jiang, Haowei Zhang, Lei Li, Fanqi Wang, Dandan Wang, Ying Mei, Yujin Din, Jianfeng Song, Wufuer Aini, Hui Zhou, Wanqin Xie, Helong Dai, Wei Liu, Joey Liu, Yan Cheng, Feng Liu, Willa A. Hsueh, Tuo Deng   +23 more
wiley   +1 more source

Globular adiponectin activates motility and regenerative traits of muscle satellite cells. [PDF]

PLoS ONE, 2012
Regeneration of adult injured skeletal muscle is due to activation of satellite cells, a population of stem cells resident beneath the basal lamina. Thus, information on soluble factors affecting satellite cell activation, as well as migration towards ...
Tania Fiaschi, Elisa Giannoni, Maria Letizia Taddei, Paola Chiarugi   +3 more
doaj   +1 more source

The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration [PDF]

, 2019
Macrophages are crucial for tissue homeostasis. Based on their activation, they might display classical/M1 or alternative/M2 phenotypes. M1 macrophages produce pro-inflammatory cytokines, reactive oxygen species (ROS), and nitric oxide (NO).
Alessio Torcinaro, Elisabetta Ferraro, Fielding RA, Francesca De Santa, Galván-Peña S, Hard GC, Huang X, Kawanishi N, Laura Vitiello, Munder M, Ménégaut L, Ohtsu A, Tidball JG, Zhang X   +13 more
core   +1 more source

Isolation, Culture and Identification of Porcine Skeletal Muscle Satellite Cells

Asian-Australasian Journal of Animal Sciences, 2015
The objective of this study was to establish the optimum protocol for the isolation and culture of porcine muscle satellite cells. Mononuclear muscle satellite cells are a kind of adult stem cell, which is located between the basal lamina and sarcolemma ...
Bo-jiang Li, Pinghua Li, Rui-hua Huang, Wen-xing Sun, Han Wang, Qifa Li, Jie Chen, Wangjun Wu, Hong-lin Liu   +8 more
semanticscholar   +1 more source

Satellite cell dynamics during skeletal muscle hypertrophy

Biochemical Society Transactions
Skeletal muscle stem cells (MuSCs) display distinct behavior crucial for tissue maintenance and repair. Upon activation, MuSCs exhibit distinct modes of division: symmetric division, facilitating either self-renewal or differentiation, and asymmetric division, which dictates divergent cellular fates.
Tolulope P. Saliu, Jensen Goh, Gyumin Kang, Benjamin I. Burke, Ahmed Ismaeel, John J. McCarthy   +5 more
openaire   +2 more sources

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Mechanism of satellite cell regulation by myokines

Journal of Physical Fitness and Sports Medicine, 2017
Skeletal muscle stem cells, known as satellite cells, participate in postnatal skeletal muscle growth, regeneration, and hypertrophy. They are quiescent in the resting state, but are activated after muscle injury, and subsequently replicate and fuse into
Yasuro Furuichi, Nobuharu L. Fujii
doaj   +1 more source

Loss of CRY2 promotes regenerative myogenesis by enhancing PAX7 expression and satellite cell proliferation

MedComm, 2023
The regenerative capacity of skeletal muscle is dependent on satellite cells. The circadian clock regulates the maintenance and function of satellite cells.
Yingxue Hao, Ting Xue, Song‐Bai Liu, Sha Geng, Xinghong Shi, Panting Qian, Wei He, Jiqing Zheng, Yanfang Li, Jing Lou, Tianze Shi, Ge Wang, Xiaoxiao Wang, Yanli Wang, Yangxin Li, Yao‐Hua Song   +15 more
doaj   +1 more source

Single‐cell RNA‐seq reveals novel interaction between muscle satellite cells and fibro‐adipogenic progenitors mediated with FGF7 signalling

Journal of Cachexia, Sarcopenia and Muscle
Muscle satellite cells (MuSCs) exert essential roles in skeletal muscle adaptation to growth, injury and ageing, and their functions are extensively modulated by microenvironmental factors.
Lu Ma, Yingying Meng, Yalong An, Peiyuan Han, Chen Zhang, Yongqi Yue, Chenglong Wen, Xin’e Shi, Jianjun Jin, Gongshe Yang, Xiao Li   +10 more
semanticscholar   +1 more source

Satellite cell depletion prevents fiber hypertrophy in skeletal muscle [PDF]

Development, 2016
The largest mammalian cells are the muscle fibers, and they have multiple nuclei to support their large cytoplasmic volumes. During hypertrophic growth, new myonuclei are recruited from satellite stem cells into the fiber syncytia, but it was recently suggested that such recruitment is not obligatory: overload hypertrophy after synergist ablation of ...
Ingrid M. Egner, Jo C. Bruusgaard, Kristian Gundersen   +2 more
openaire   +2 more sources