Results 101 to 110 of about 25,548 (305)

Age-related loss of skeletal muscle function; impairment of gene expression.

, 2004
Mechano Growth Factor (MGF) is derived from the insulin-like growth factor (IGF-I) but its sequence differs from the systemic IGF-I produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation.
Goldspink, G
core  

PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy [PDF]

, 2007
The coactivator PGC-1alpha mediates key responses of skeletal muscle to motor nerve activity. We show here that neuregulin-stimulated phosphorylation of PGC-1alpha and GA-binding protein (GABP) allows recruitment of PGC-1alpha to the GABP complex and ...
Handschin, C., Kobayashi, Y M, Chin, S, Kobayashi, Y. M., Seale, P., Seale, P, Spiegelman, B. M., Handschin, C, Campbell, K. P., Campbell, K P, Spiegelman, B M, Chin, S.   +11 more
core   +1 more source

Towards Advanced Intelligent and Perceptive Soft Grippers

Advanced Intelligent Systems, EarlyView.
Implementing soft yet strong and intelligent soft grippers request innovative and creative solutions in designing soft bodies and seamlessly integrating actuated systems with hierarchical sensing. This review systematically analyses soft grippers with a deep understanding of core components, from fundamental design principles to actuation and sensing ...
Haneul Kim, Hayeon Shin, Seik Park, Changbeom Shim, Seonggun Joe   +4 more
wiley   +1 more source

Developmental stage determines efficiency of gene transfer to muscle satellite cells by in utero delivery of adeno-associated virus vector serotype 2/9

Molecular Therapy: Methods & Clinical Development, 2014
Efficient gene transfer to muscle stem cells (satellite cells) has not been achieved despite broad transduction of skeletal muscle by systemically administered adeno-associated virus serotype 2/9 (AAV-9) in mice.
David H Stitelman, Tim Brazelton, Archana Bora, Jeremy Traas, Demetri Merianos, Maria Limberis, Marcus Davey, Alan W Flake   +7 more
doaj   +1 more source

The role of myostatin during postnatal myogenesis and sarcopenia

, 2007
Myostatin, a TGF-β superfamily member, is a key negative regulator of embryonic and postnatal muscle growth. In order to further elucidate the role of myostatin during postnatal growth, several lines of investigation were undertaken in mice.
Siriett, Victoria Katherine
core  

Nutritional intervention during gestation alters growth, body composition and gene expression patterns in skeletal muscle of pig offspring

, 2011
peer-reviewedVariations in maternal nutrition during gestation can influence foetal growth, foetal development and permanently ‘programme’ offspring for postnatal life.
Markham, T., L. Giblin, Stickland, N C, O'Reilly, J J, O'Reilly, James J, Stickland, N. C., T. Markham, Lawlor, P G, P.G. Lawlor, J.P. Kerry, Lawlor, Peadar G, Lynch, P Brendan, Lynch, P B, Markham, T C W, Teagasc Anim & Grassland Res, P.B. Lynch, Kerry, J P, Teagasc Food Res Centre, N.C. Stickland, D.P. Berry, University College Cork, Mc Namara, Louise, L.B. McNamara, Kerry, Joseph P., Giblin, Linda, McNamara, L B, J.J. O'Reilly, Giblin, L, Berry, D P, Berry, Donagh   +29 more
core   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Notch signaling in the regulation of skeletal muscle stem cells

Journal of Physical Fitness and Sports Medicine, 2018
Resident muscle stem cells are satellite cells that are responsible for the postnatal maintenance, growth, repair, and regeneration of skeletal muscle. In healthy adult muscle, satellite cells are mitotically quiescent, but are activated in response to ...
Shin Fujimaki, Yusuke Ono
doaj   +1 more source

The Effect of Pax3 Over-expression on Myoblast Function

, 2009
The paired-box transcription factor 3 (Pax3), is a powerful myogenic regulatory factor during embryo-myogenesis. The expression of Pax3 is involved in determining somitic cell fate, resulting in the formation of the first differentiated muscle, the ...
Brijs, Erik
core  

: Role of Cripto in skeletal muscle regeneration

, 2012
International audienceSkeletal muscle regeneration mainly depends on satellite cells, a population of resident muscle stem cells. However, our understanding of the molecular mechanisms underlying satellite cell activation is still largely undefined. Here,
Iaconis, S., Guardiola, Ombretta, Brunelli, Silvia, Shen, Michael, M., Touvier, Thierry, Lonardo, Enza, Iaconis, Salvatore, Cossu, Giulio, Bouche, A., Liguori, Giovanna L., Liguori, Giovanna,, Lafuste, Peggy, Shen, M., Mourikis, Philippos, Bouché, Ann, Guardiola, O., Minchiotti, Gabriella, Liguori, G., Carmeliet, Peter, Andolfi, G., Tajbakhsh, S., Minchiotti, G., de Bock, Katrien, Andolfi, Gennaro, Brunelli, S., Shen, Michael M., de Bock, K., Mourikis, P., Lonardo, E., Lafuste, P., Liguori, Giovanna, L., Shen, Michael,, Tajbakhsh, Shahragim, Touvier, T., Cossu, G., Carmeliet, P.   +35 more
core   +1 more source