Results 91 to 100 of about 25,548 (305)

Mechanism of myostatin action during satellite cell activation and muscle wasting.

, 2007
Myostatin, a Transforming Growth Factor-beta (TGF-β) superfamily member, has been well characterised as a negative regulator of muscle growth and development.
McFarlane, Craig Desmond
core  

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy [PDF]

, 2009
Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2, respectively.
Richard-Bulteau, Hélène, Arnaud Ferry, Pende, Mario, Rüegg, Markus,, Hantaï, Daniel, Mario Pende, Le-Marchand-Brustel, Yannick, Kozma, Sara, Corneloup, Claudine, Laetitia Mazelin, Ferrier, Bernard, Hervé Sanchez, Koulmann, Nathalie, Claudine Corneloup, Bigard, Xavier, Daniel Hantaï, Rüegg, Markus, A., Hélène Richard-Bulteau, Mueller, Matthias, Bauché, Stéphanie, Moncollin, Vincent, Roceri, Mila, Jean-François Tanti, Conjard-Duplany, Agnès, Vignaud, Alban, Alban Vignaud, Stéphanie Bauché, Xavier Bigard, Freyssenet, Damien, Agnès Conjard-Duplany, Tanti, Jean-François, Laurent Schaeffer, Thomas, George, Mazelin, Laetitia, Defour, Aurélia, Aurélia Defour, Romanino, Klaas, Damien Freyssenet, Yannick Le-Marchand-Brustel, Bernard Ferrier, Nathalie Koulmann, George Thomas, Sanchez, Hervé, Baas, Dominique, Klaas Romanino, Sara C. Kozma, Mila Roceri, Kozma, Sara C., Rüegg, Markus A., Yann-Gaël Gangloff, Schaeffer, Laurent, Matthias Mueller, Vincent Moncollin, Markus A. Rüegg, Ferry, Arnaud, Gangloff, Yann-Gaël, Dominique Baas, Risson, Valérie, Valérie Risson   +58 more
core   +1 more source

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, EarlyView.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

The Ubiquitin-Proteasome System Is Indispensable for the Maintenance of Muscle Stem Cells

Stem Cell Reports, 2018
Summary: Adult muscle stem cells (satellite cells) are required for adult skeletal muscle regeneration. A proper balance between quiescence, proliferation, and differentiation is essential for the maintenance of the satellite cell pool and their ...
Yasuo Kitajima, Naoki Suzuki, Aki Nunomiya, Shion Osana, Kiyoshi Yoshioka, Yoshitaka Tashiro, Ryosuke Takahashi, Yusuke Ono, Masashi Aoki, Ryoichi Nagatomi   +9 more
doaj   +1 more source

The Effect of Resistance Training and Ursolic Acid on the PI3K‐AKT‐mTOR Pathway in Aged Diabetic Rats: A Comparative Study

AGING MEDICINE, EarlyView.
Resistance training combined with ursolic acid supplementation restores anabolic signaling (PI3K/mTORC1) suppressed by diabetes, helping preserve muscle mass. This strategy may offer a potential therapeutic approach to combat muscle atrophy and support healthy aging in diabetic conditions.
Ashkan Sadeghi, Safoura Alizade, Mohammad Faramarzi, Mostafa Rahimi, Rohit Kumar Thapa   +4 more
wiley   +1 more source

Condition optimization for electroporation transfection in horse skeletal muscle satellite cells

Animal Biotechnology
Satellite cells are an important cellular model for studying muscle growth and development and mammalian locomotion-related molecular mechanisms. In this study, we investigated the effects of voltage, pulse duration, and DNA dosage on horse skeletal ...
Tseweendolmaa Ulaangerel, Minna Yi, Undarmaa Budsuren, Yingchao Shen, Hong Ren, Bold Demuul, Dongyi Bai, Dulguun Dorjgotov, Gantulga Davaakhuu, Tuyatsetseg Jambal, Manglai Dugarjav, Gerelchimeg Bou   +11 more
doaj   +1 more source

Conditional Cripto overexpression in satellite cells promotes myogenic commitment and enhances early regeneration

Frontiers in Cell and Developmental Biology, 2015
Skeletal muscle regeneration mainly depends on satellite cells, a population of resident muscle stem cells. Despite extensive studies, knowledge of the molecular mechanisms underlying the early events associated with satellite cell activation and ...
Carolina ePrezioso, Salvatore eIaconis, Gennaro eAndolfi, Lorena eZentilin, Francescopaolo eIavarone, Ombretta eGuardiola, Gabriella eMinchiotti   +6 more
doaj   +1 more source

Elucidating the Role of BRCA1 in Skeletal Muscle Myogenesis and Function

, 2023
The breast cancer 1 early onset gene (BRCA1) is a tumor suppressor gene susceptible to mutations associated with cancer development. We have identified that the BRCA1 gene is expressed in skeletal muscle and plays a critical role in regulating muscle ...
Koripella, Ananya, NC DOCKS at East Carolina University   +1 more
core  

Biomarkers of Sarcopenia: Current Status and Future Perspectives

AGING MEDICINE, EarlyView.
In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo, Wenhan Li, Yi Zhang, Mengchen Liu, Kemeng Zhang, Sui Huang, Ping He   +6 more
wiley   +1 more source

Exercise and skeletal muscle regeneration

Journal of Physical Fitness and Sports Medicine, 2012
Skeletal muscle injury is generally caused by stimuli, such as intense resistance training, eccentric muscle contraction, muscle strain and bruising. Injured skeletal muscles are repaired within several weeks after injury, because skeletal muscle has a ...
Mitsutoshi Kurosaka, Shuichi Machida
doaj   +1 more source