Results 181 to 190 of about 142,521 (283)

A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819. [PDF]

Sci Adv, 2022
Fernandes LP, Enriquez-Gasca R, Gould PA, Holt JH, Conde L, Ecco G, Herrero J, Gifford R, Trono D, Kassiotis G, Rowe HM.   +10 more
europepmc   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Satellite DNA shapes dictate pericentromere packaging in female meiosis. [PDF]

Nature
Dudka D, Dawicki-McKenna JM, Sun X, Beeravolu K, Akera T, Lampson MA, Black BE.   +6 more
europepmc   +1 more source

Integration of Repeatomic and Cytogenetic Data on Satellite DNA for the Genome Analysis in the Genus Salvia (Lamiaceae). [PDF]

Plants (Basel), 2022
Muravenko OV, Yurkevich OY, Kalnyuk JV, Samatadze TE, Zoshchuk SA, Amosova AV.   +5 more
europepmc   +1 more source

Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentromeric heterochromatin of chromosomes 13, 21 and 18 [PDF]

, 1986
Bakker, E., Cornelisse, J. L., Cremer, Thomas, Devilee, P., Hager, H. D., Pearson, P., Scholl, Hans Peter, Slagboom, P., Stevenson, A. F. G.   +8 more
core  

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

First Description of a Satellite DNA in Manatees' Centromeric Regions. [PDF]

Front Genet, 2021
Valeri MP, Dias GB, do Espírito Santo AA, Moreira CN, Yonenaga-Yassuda Y, Sommer IB, Kuhn GCS, Svartman M.   +7 more
europepmc   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Sequenced genomes and chromosome mapping illuminate key aspects of satellite DNA biology in Drosophila gouveai and D. borborema (buzzatii cluster, repleta group). [PDF]

Genet Mol Biol
Rossi AC, Laborne AM, Barrios-Leal DY, Manfrin MH, Kuhn GCS.   +4 more
europepmc   +1 more source

Sequence, Chromatin and Evolution of Satellite DNA. [PDF]

Int J Mol Sci, 2021
Thakur J, Packiaraj J, Henikoff S.
europepmc   +1 more source