Results 31 to 40 of about 549,124 (265)

Chemical insights into the synthetic chemistry of five-membered saturated heterocycles—a transition metal–catalyzed approach

Frontiers in Chemistry, 2023
Drug design and delivery is primarily based on the hunt for new potent drug candidates and novel synthetic techniques. Recently, saturated heterocycles have gained enormous attention in medicinal chemistry as evidenced by the medicinal drugs listed in ...
Sunbal, Muhammad Alamzeb, Muhammad Omer, Obaid-Ur-Rahman Abid, Mohib Ullah, Muhammad Sohail, Ihsan Ullah   +6 more
doaj   +1 more source

Saturation for Small Antichains

The Electronic Journal of Combinatorics, 2023
For a given positive integer $k$ we say that a family of subsets of $[n]$ is $k$-antichain saturated if it does not contain $k$ pairwise incomparable sets, but whenever we add to it a new set, we do find $k$ such sets. The size of the smallest such family is denoted by $\text{sat}^*(n, \mathcal A_{k})$. Ferrara, Kay, Kramer, Martin, Reiniger, Smith and
Irina Ðankovic, Maria-Romina Ivan
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Transferrin Saturation and Mortality [PDF]

Clinical Chemistry, 2011
To the Editor: Ellervik and colleagues (1) recently reported a positive association between transferrin saturation (TS) and mortality. Several questions arise from this observation: Is the association due to all causes of iron overload or to hereditary hemochromatosis only? Does the study underestimate the true association?
Benyamin, Beben, Montgomery, Grant W., Martin, Nicholas G., Whitfield, John B.   +3 more
openaire   +5 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Dynamic Tensile Response of Seawater Coral Aggregate Concrete (SCAC) in Saturated State: Experimental and Numerical Simulation Study

Buildings
Seawater Coral Aggregate Concrete (SCAC), made using coral aggregates from marine environments, is gaining attention as a promising material for marine and coastal engineering applications.
Rui Li, Chaomin Mu, Yulin Qin, Hui Zhou, Quanmin Xie   +4 more
doaj   +1 more source

Saturation Numbers of Books [PDF]

The Electronic Journal of Combinatorics, 2008
A book $B_p$ is a union of $p$ triangles sharing one edge. This idea was extended to a generalized book $B_{b,p}$, which is the union of $p$ copies of a $K_{b+1}$ sharing a common $K_b$. A graph $G$ is called an $H$-saturated graph if $G$ does not contain $H$ as a subgraph, but $G\cup \{xy\}$ contains a copy of $H$, for any two nonadjacent vertices $x$
Guantao Chen, Ralph J. Faudree, Ronald J. Gould   +2 more
openaire   +3 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source