Results 31 to 40 of about 168,622 (262)

Studies on human serum lipoprotein phospholipids and phospholipid fatty acid composition by silicic acid chromatography*

Journal of Lipid Research, 1962
Normal human serum phospholipids were fractionated by silicic acid column chromatography. A large number of fractions was obtained with which it was possible to study the effect of fatty acid composition on elution rate.
Gary J. Nelson
doaj   +1 more source

Lipidomic Profiling of Murine Macrophages Treated with Fatty Acids of Varying Chain Length and Saturation Status

Metabolites, 2018
Macrophages are abundant within adipose tissue depots where they are exposed to fatty acids, leading to lipid accumulation. Herein, we have determined the effects of various fatty acids on the macrophage lipidome.
Kevin Huynh, Gerard Pernes, Natalie A. Mellett, Peter J. Meikle, Andrew J. Murphy, Graeme I. Lancaster   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Variation in Fatty Acids Composition Including Trans Fat in Different Brands of Potato Chips by GC-MS [PDF]

Pakistan Journal of Analytical & Environmental Chemistry, 2010
Twelve different brands of potato chips were analyzed for their fatty acid compositions with eminence on trans fatty acid (TFA) using GC-MS. Results of the present study showed that the dominant fatty acids were saturated fatty acids. Among the saturated
Aftab A. Kandhro, S. T. H. Sherazi, S. A. Mahesar, M. Younis Talpur, Yawar Latif   +4 more
doaj  

Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model [PDF]

, 2001
The desaturation of [1-14C]18:3n-3 to docosahexaenoic acid (DHA; 22:6n-3) is enhanced in an essential fatty acid deficient cell line (EPC-EFAD) in comparison with the parent cell line (EPC) from carp. In the present study, the effects of DHA on lipid and
Tocher, Douglas R, Dick, James R
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Description of amino acid and fatty acid content during initial development of Lophiosilurus alexandri (Siluriformes: Pseudopimelodidae), a carnivorous freshwater catfish

Neotropical Ichthyology, 2018
Samples of eggs, newly hatched larvae (NHL), and larvae at the end of the lecithotrophic period (eight days after hatching) (LPL) of Lophiosilurus alexandri were collected to determine the amino acid and fatty acid profiles.
Deliane Cristina Costa, Rodrigo Takata, Walisson de Souza e Silva, Martin Bessonart, Juan Luis Gadea, Larisa Magnone, Ronald Kennedy Luz   +6 more
doaj   +1 more source

The burden of excessive saturated fatty acid intake attributed to ultra-processed food consumption: a study conducted with nationally representative cross-sectional studies from eight countries

Journal of Nutritional Science, 2021
Cross-sectional nutritional survey data collected in eight countries were used to estimate saturated fatty acid intakes. Our objective was to estimate the proportion of excessive saturated fatty acid intakes (>10 % of total energy intake) that could be ...
Eurídice Martínez Steele, Carolina Batis, Gustavo Cediel, Maria Laura da Costa Louzada, Neha Khandpur, Priscila Machado, Jean-Claude Moubarac, Fernanda Rauber, Marcela Reyes Jedlicki, Renata Bertazzi Levy, Carlos A. Monteiro   +10 more
doaj   +1 more source

Differences in fatty acid composition between cerebral brain lobes in juvenile pigs after fish oil feeding

, 2008
Very long-chain n-3 PUFA from fish are suggested to play a role in the development of the brain. Fish oil feeding results in higher proportions of n-3 PUFA in the brains of newborn piglets. However, the effect of fish oil on the fatty acid composition of
Coronel, R., den Ruijter, Hester M., Brummer, Robert-Jan M., Den Ruijter, H.M., Kok, F.J., Ruijter, H.M., den, Brouwer, Ingeborg A., Brouwer, I.A.; id_orcid, Katan, Martijn B., Brummer, R.J., Kok, Frans J., Brummer, Robert,, Zock, Peter L., Brouwer, I.A., Beekman, J., Ruijter, H.M. den, Dullemeijer, C., Katan, M.B.; id_orcid, Zock, P.L., Beekman, Jet, Katan, M.B., Coronel, Ruben, Dullemeijer, Carla   +22 more
core   +1 more source