Results 171 to 180 of about 2,724 (205)
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Cornea, 2001
The aim of the current study was to define the efficacy of saxitoxin as a corneal anesthetic in rabbits after mechanical corneal abrasion and photorefractive keratectomy (PRK).Twelve Dutch belted rabbits were given a single 1.2-microg dose of saxitoxin or vehicle after mechanical abrasion of the cornea.
K G, Duncan, J L, Duncan, D M, Schwartz
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The aim of the current study was to define the efficacy of saxitoxin as a corneal anesthetic in rabbits after mechanical corneal abrasion and photorefractive keratectomy (PRK).Twelve Dutch belted rabbits were given a single 1.2-microg dose of saxitoxin or vehicle after mechanical abrasion of the cornea.
K G, Duncan, J L, Duncan, D M, Schwartz
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ChemInform Abstract: Saxitoxin
ChemInform, 2014AbstractReview: [chemistry and chemical biology; 162 refs.
Arun P. Thottumkara +2 more
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The surface waters contaminated with cyanobacteria, which are utilized for drinking, irrigation, and recreational purposes, poses a potential hazard to population health, as well as domestic animals and wildlife. Due to the observed trends of rising temperatures and the increased levels of nutrient pollution in surface waters, the occurrence of marine ...
Senanur Ozsoy +2 more
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Senanur Ozsoy +2 more
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Neutralization of saxitoxin by anti-saxitoxin rabbit serum
Toxicon, 1985This study examined the ability of anti-saxitoxin rabbit serum to neutralize saxitoxin, both in vitro and in vivo. In vitro, two rabbit antisera decreased [3H]-saxitoxin binding to specific sites in rat brain membranes. The more potent of these sera, antiserum A, when combined with saxitoxin in vitro, decreased saxitoxin's lethal potency based on mouse
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Pure and Applied Chemistry, 2012
Saxitoxin (STX), a neurotoxin isolated from Alaskan butter clam, Saxidomus giganteus, inhibits voltage-gated sodium channels by binding to the pore-forming p-loop region. Here we describe stereospecific syntheses of STX and its natural derivatives, (+)-decarbamoylsaxitoxin (dcSTX) and (+)-gonyautoxin3 (GTX3).
Osamu Iwamoto +2 more
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Saxitoxin (STX), a neurotoxin isolated from Alaskan butter clam, Saxidomus giganteus, inhibits voltage-gated sodium channels by binding to the pore-forming p-loop region. Here we describe stereospecific syntheses of STX and its natural derivatives, (+)-decarbamoylsaxitoxin (dcSTX) and (+)-gonyautoxin3 (GTX3).
Osamu Iwamoto +2 more
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Journal of the American Chemical Society, 1975
Saxitoxin is a neurotoxin found in various molluscs. The p-bromobenzenesulfonate-saxitoxin was crystallized and the structure was determined by single-crystal x-ray diffraction. Bond distances and angles were discussed, and a computer generated drawing of the final x-ray model was presented. (DDA)
E. J. Schantz +6 more
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Saxitoxin is a neurotoxin found in various molluscs. The p-bromobenzenesulfonate-saxitoxin was crystallized and the structure was determined by single-crystal x-ray diffraction. Bond distances and angles were discussed, and a computer generated drawing of the final x-ray model was presented. (DDA)
E. J. Schantz +6 more
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The Journal of Pharmacology and Experimental Therapeutics, 2004
Saxitoxin (STX) and tetrodotoxin (TTX) are frequently used to selectively block sodium channels. In this study, we provide evidence that commercial STX also inhibits L-type Ca2+ currents (I(Ca,L)) in adult mouse ventricular myocytes (VMs) and tsA-201 cells that were transiently cotransfected with three calcium channel subunits.
Zhi, Su +4 more
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Saxitoxin (STX) and tetrodotoxin (TTX) are frequently used to selectively block sodium channels. In this study, we provide evidence that commercial STX also inhibits L-type Ca2+ currents (I(Ca,L)) in adult mouse ventricular myocytes (VMs) and tsA-201 cells that were transiently cotransfected with three calcium channel subunits.
Zhi, Su +4 more
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First report of saxitoxin in octopi
Toxicon, 2004We report for the first time, the presence of saxitoxin (STX) in a common cephalopod, Octopus (Abdopus) sp. 5, collected from Cooke Point on the northern coastline of Western Australia. Sodium channel and saxiphilin based radio-receptor assays detected saxitoxin-like binding in octopi extracts.
Robertson, Alison +4 more
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Synthesis of Saxitoxin and Its Derivatives
Organic Letters, 2020The chiral synthesis of (+)-saxitoxin and its derivatives is described. Two consecutive carbon-nitrogen bonds at C-5 and C-6 in saxitoxin were effectively installed by the sequential Overman rearrangement of an allylic vicinal diol derived from d-malic acid.
Yuya Okuyama +5 more
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ChemInform Abstract: STRUCTURE OF A CRYSTALLINE DERIVATIVE OF SAXITOXIN. STRUCTURE OF SAXITOXIN
Chemischer Informationsdienst, 1976AbstractAufgrund der 13C‐NMR‐Spektroskopie liegt Saxitoxin, das Gift von Schalentieren, in wäß‐ rigen Lösungen als Hydrat vor.
JON BORDNER +3 more
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