MicrobiologyOpen, Volume 9, Issue 8, August 2020., 2020 Previous work on antibiotic‐tolerant persisters of pathogenic Escherichia coli highlighted the role of PasT, described as a toxin of a toxin–antitoxin system, in their resilience. Here, we show that PasT is not a toxin but rather the bacterial homolog of mitochondrial Coq10 that guides the electron carrier ubiquinone in respiratory electron transport ...
Cinzia Fino +5 more
wiley +1 more source
A synthetic Escherichia coli predator–prey ecosystem [PDF]
, 2008 We have constructed a synthetic ecosystem consisting of two Escherichia coli populations, which communicate bi-directionally through quorum sensing and regulate each other's gene expression and survival via engineered gene circuits.
Cynthia H Collins +10 more
core +3 more sources
Mutual regulation causes co-entrainment between a synthetic oscillator and the bacterial cell cycle [PDF]
, 2015 The correct functioning of cells requires the orchestration of multiple cellular processes, many of which are inherently dynamical. The conditions under which these dynamical processes entrain each other remain unclear.
Dies, Marta +2 more
core +2 more sources
Efficient synthesis of L-lactic acid from glycerol by metabolically engineered Escherichia coli [PDF]
, 2013 Due to its abundance and low-price, glycerol has become an attractive carbon source for the industrial production of value-added fuels and chemicals. This work reports the engineering of E.
Blankschien, Matthew D +3 more
core +2 more sources
Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer. [PDF]
Clin Cancer Res, 2023 PURPOSE: Therapeutic resistance to frontline therapy develops rapidly in small cell lung cancer (SCLC). Treatment options are also limited by the lack of targetable driver mutations.
Ramkumar K +16 more
europepmc +3 more sources
Genome sequencing analysis of Streptomyces coelicolor mutants that overcome the phosphate-depending vancomycin lethal effect [PDF]
, 2018 Background Glycopeptide antibiotics inhibit bacterial cell-wall synthesis, and are important for the treatment of infections caused by multi drug-resistant strains of enterococci, streptococci and staphylococci.
Santos Beneit, Fernando
core +1 more source
Proof of concept continuous event logging in living cells [PDF]
, 2017 Cells must detect and respond to molecular events such as the presence or absence of specific small molecules. To accomplish this, cells have evolved methods to measure the presence and concentration of these small molecules in their environment and ...
Murray, Richard M., Shur, Andrey
core +1 more source
Environmental Perturbations Lift the Degeneracy of the Genetic Code to Regulate Protein Levels in Bacteria [PDF]
, 2014 The genetic code underlying protein synthesis is a canonical example of a degenerate biological system. Degeneracies in physical and biological systems can be lifted by external perturbations, thus allowing degenerate systems to exhibit a wide range of ...
Cluzel, Philippe +2 more
core +1 more source
Stem Cells International, Volume 2019, Issue 1, 2019., 2019 The identification of several evolutionary young miRNAs, which arose in primates, raised several possibilities for the role of such miRNAs in human‐specific disease processes. We previously have identified an evolutionary young miRNA, miR‐1290, to be essential in neural stem cell proliferation and neuronal differentiation.
Dalia Moore +11 more
wiley +1 more source
Taxonomy of asteroid families among the Jupiter Trojans: Comparison between spectroscopic data and the Sloan Digital Sky Survey colors [PDF]
, 2007 We present a comparative analysis of the spectral slope and color distributions of Jupiter Trojans, with particular attention to asteroid families. We use a sample of data from the Moving Object Catalogue of the Sloan Digital Sky Survey, together with ...
A. O. Ribeiro +36 more
core +2 more sources