Results 71 to 80 of about 954,074 (407)
Bioactive Glasses: Where Are We and Where Are We Going?
Journal of Functional Biomaterials, 2018 Bioactive glasses caused a revolution in healthcare and paved the way for modern biomaterial-driven regenerative medicine. The first 45S5 glass composition, invented by Larry Hench fifty years ago, was able to bond to living bone and to stimulate ...
Francesco Baino +2 more
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Cytochrome P450 Enzymes as Key Drivers of Alkaloid Chemical Diversification in Plants
Frontiers in Plant Science, 2021 Plants produce more than 20,000 nitrogen-containing heterocyclic metabolites called alkaloids. These chemicals serve numerous eco-physiological functions in the plants as well as medicines and psychedelic drugs for human for thousands of years, with the ...
Trinh-Don Nguyen, Thu-Thuy T. Dang
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Identification of Bioisosteric Scaffolds using Scaffold Keys [PDF]
, 2021 Replacement of a central scaffold in a bioactive molecule by another scaffold with similar structural features (a procedure called sometimes "scaffold hopping") is a classical medicinal chemistry technique used to improve molecular properties and explore novel interesting areas of chemical space.
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FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard +7 more
wiley +1 more source
Bioactive Glasses: From Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies
Journal of Functional Biomaterials, 2018 Nowadays, bioactive glasses (BGs) are mainly used to improve and support the healing process of osseous defects deriving from traumatic events, tumor removal, congenital pathologies, implant revisions, or infections.
Elisa Fiume +3 more
doaj +1 more source
Application of poly(lactic-co-glycolic acid) in the treatment of pulp diseases
口腔疾病防治, 2021 The development of materials science is of great significance to the treatment of dental pulp diseases. Poly lactic acid glycolic acid (PLGA) copolymer is an organic macromolecule compound that is widely used in the preparation of biomedical materials ...
ZHOU Fangjie, HE Libang, LI Jiyao
doaj +1 more source
Nature Materials, 2016 We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable, branched, three-dimensional microchannel network coated with ...
Boyang Zhang +17 more
semanticscholar +1 more source
Bioresorbable Scaffolds for Atheroregression: Understanding of Transient Scaffolding [PDF]
Current Cardiology Reviews, 2016 This review focuses on the clinical and biological features of the bioresorbable scaffolds in interventional cardiology highlighting scientific achievements and challenges of the transient scaffolding with Absorb BVS. Special attention is granted to the vascular biology pathways which, involved in the resorption of scaffold, artery remodeling and ...
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FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti +2 more
wiley +1 more source
Mathematical modelling of fibre-enhanced perfusion inside\ud a tissue-engineering bioreactor [PDF]
, 2009 We develop a simple mathematical model for forced flow of culture medium through a porous scaffold in a tissue- engineering bioreactor. Porous-walled hollow fibres penetrate the scaffold and act as additional sources of culture medium.
Bailey, Clare +16 more
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