Results 81 to 90 of about 1,015,982 (386)

Advances in Porous Scaffold Design for Bone and Cartilage Tissue Engineering and Regeneration.

Tissue engineering. Part B, Reviews, 2019
IMPACT STATEMENT Challenges in musculoskeletal tissue regeneration affect millions of patients globally. Scaffolds for tissue engineering bone and cartilage provide promising solutions that increase healing and decrease need for complicated surgical ...
A. Cheng, Z. Schwartz, A. Kahn, Xiyu Li, Zhenxing Shao, Muyang Sun, Y. Ao, B. Boyan, Haifeng Chen   +8 more
semanticscholar   +1 more source

Scaffolding a Skeleton [PDF]

, 2018
The goal of this paper is to construct a quadrilateral mesh around a one-dimensional skeleton that is as coarse as possible, the " scaffold ". A skeleton allows one to quickly describe a shape, in particular a complex shape of high genus. The constructed scaffold is then a potential support for the surface representation: it provides a topology for the
Panotopoulou, Athina, Ross, Elissa, Welker, Kathrin, Hubert, Evelyne, Morin, Géraldine   +4 more
openaire   +3 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

The effect of various concentrations of HA-TCP derived from cockle shell synthesis on scaffold porosity

Dental Journal, 2018
Background: Porosity is an important property that must be possessed by scaffold due to its role in new bone growth. Hydroxyapatite is a scaffold material with a composition resembling that of bone that can be synthesized from cockle shell (Anadara ...
Reyhan Alvaryan Ferdynanto, Priska Evita Setia Dharmayanti, Putu Tahlia Krisna Dewi, Widyasri Prananingrum   +3 more
doaj   +1 more source

Identification of Bioisosteric Scaffolds using Scaffold Keys [PDF]

, 2021
Replacement of a central scaffold in a bioactive molecule by another scaffold with similar structural features (a procedure called sometimes "scaffold hopping") is a classical medicinal chemistry technique used to improve molecular properties and explore novel interesting areas of chemical space.
openaire   +4 more sources

Stöttningsinteraktion: Undervisningssituationens scaffolding?

Kapet, 2023
I den här artikeln prövas ett nytt svenskt begrepp för engelskans scaffolding, nämligen stöttningsinteraktion. Syftet är att med hjälp av en adekvat svensk benämning skapa en gemensam förståelse av ett komplext begrepp och därigenom vidga förståelsen för dess användning i undervisningssammanhang.
Forsling, Karin, Tjernberg, Catharina
openaire   +2 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Tissue engineering a fetal membrane [PDF]

, 2011
The aim of this study was to construct an artificial fetal membrane (FM) by combination of human amniotic epithelial stem cells (hAESCs) and a mechanically enhanced collagen scaffold containing encapsulated human amniotic stromal fibroblasts (hASFs ...
Adam M. Squires, Anna L. David, Bipasha Chowdhury, Che John Connon, Connon C.J., Grinnell F., Ian William Hamley, Jones R.R., Kirkham S.M., Roanne Razalia Jones, Shengli Mi, Trinkaus R.V.   +11 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Bone substitute effect on vascularization and bone remodeling after application of phVEGF165 transfected BMSC [PDF]

, 2012
VEGF (vascular endothelial growth factor) promotes vascularization and remodeling of bone substitutes. The aim of this study was to examine the effect of distinct resorbable ceramic carriers on bone forming capacities of VEGF transfected bone marrow ...
Beverungen, Mirjam, Fehr, Michael, Geiger, Florian, Kasten, Philip, Lorenz, Helga, Wieland, Julia   +5 more
core   +2 more sources