Results 61 to 70 of about 222,566 (219)

Evolving Strategies and Materials for Scaffold Development in Regenerative Dentistry

Applied Sciences
Regenerative dentistry has experienced remarkable advancement in recent years. The interdisciplinary discoveries in stem cell applications and scaffold design and fabrication, including novel techniques and biomaterials, have demonstrated immense ...
Michal Gašparovič, Petra Jungová, Juraj Tomášik, Bela Mriňáková, Dušan Hirjak, Silvia Timková, Ľuboš Danišovič, Marián Janek, Ľuboš Bača, Peter Peciar, Andrej Thurzo   +10 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Gum Arabic: A Commodity with Versatile Formulations and Applications

Nanomaterials
Gum Arabic (GA), or acacia gum, refers to the dried exudate produced by certain Acacia trees. GA is composed mainly of a mixture of polysaccharides and glycoproteins, with proportions that can slightly differ from one species to another.
Shaymaa A. Mohamed, Asmaa M. Elsherbini, Heba R. Alrefaey, Kareem Adelrahman, Alshaimaa Moustafa, Nishal M. Egodawaththa, Kaitlyn E. Crawford, Nasri Nesnas, Sally A. Sabra   +8 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Decellularization techniques: unveiling the blueprint for tracheal tissue engineering

Frontiers in Bioengineering and Biotechnology
Certain congenital or acquired diseases and defects such as tracheo-oesophageal fistula, tracheomalacia, tracheal stenosis, airway ischemia, infections, and tumours can cause damage to the trachea.
Keisha T. Gomes, Palla Ranga Prasad, Jagnoor Singh Sandhu, Jagnoor Singh Sandhu, Ashwini Kumar, Naveena A. N. Kumar, N. B. Shridhar, Bharti Bisht, Manash K. Paul, Manash K. Paul   +9 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Novel and rapid analytical platform development enabled by advances in 3D printing

Frontiers in Analytical Science
3-Dimensional (3D) printing technology has greatly facilitated the recent advancements in science and engineering that benefit many aspects of scientific investigation, with examples including disease diagnostics, dentistry, aerospace, and fundamental ...
Alexander S. Malinick, Cole P. Ebel, Daniel D. Stuart, Santino N. Valiulis, Victor A. Hanson, Quan Cheng   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Optimization of Bioinspired Scaffolds to Enhance Cell Viability and Enable Tissue Growth

Proceedings
The construction of artificial biological tissues presents complex interdisciplinary challenges, requiring the convergence of knowledge from materials science, biophysics, biology, design, and related fields.
Jackeline de Oliveira Riqueira, Danilo Barbosa Liarte, Silvia Lenyra Meirelles Campos Titotto   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source