Results 21 to 30 of about 2,580 (206)
Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner [PDF]
Journal of Lipid Research, 2016 Sterol regulatory element-binding protein (SREBP) transcription factors are central regulators of cellular lipid homeostasis and activate expression of genes required for fatty acid, triglyceride, and cholesterol synthesis and uptake. SREBP cleavage activating protein (SCAP) plays an essential role in SREBP activation by mediating endoplasmic reticulum
Wei Shao (邵威) +2 more
openaire +3 more sources
Eurasian Journal of Physics and Functional Materials, 2021 In this paper, the features of the characteristics of model thin-film solar cells based on the non-toxic multicomponent compound CuZn2AlS4 (CZAS) are considered.
D. Sergeyev +3 more
doaj +1 more source
Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER [PDF]
Proceedings of the National Academy of Sciences, 2002 Sterols inhibit their own synthesis in mammalian cells by blocking the vesicular endoplasmic reticulum-to-Golgi transport of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), a sterol-sensing protein that escorts SREBPs.
Peter J, Espenshade +2 more
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An update to the list of coral reef fishes from Koh Tao, Gulf of Thailand [PDF]
Check List, 2014 Twenty-one species are reported for the first time from Koh Tao (Turtle Island) in the Gulf of Thailand. Information and photographs were obtained from local scuba divers in order to census rare (i.e., cryptic species or transient species only present ...
Patrick Scaps, Chad Scott
doaj +3 more sources
Sugar Makes Fat by Talking to SCAP [PDF]
Cancer Cell, 2015 Elevated blood glucose promotes lipogenesis via activating SREBP transcription factors. Tumors exhibit increased glucose uptake and lipogenesis, but the mechanisms controlling this are poorly understood. In this issue of Cancer Cell, Cheng and colleagues find that glucose activates SREBP by stabilizing SCAP, a central regulator of the SREBP pathway.
Shao, Wei, Espenshade, Peter J.
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Stem Cells International, 2020 Objective. Parathyroid hormone (PTH) is considered to be essential during the tooth development. Stem cells from the apical papilla (SCAPs) are responsible for dentine formation. However, the interaction between PTH and SCAPs remains unclear.
Xiyao Pang +7 more
doaj +1 more source
Structural basis for sterol sensing by Scap and Insig [PDF]
Cell Reports, 2021 Abstract The sterol regulatory element-binding protein (SREBP) pathway senses the cellular cholesterol level through sterol regulated association between Scap and Insig. Despite the recent structural determination of the transmembrane domains of human Scap and Insig-2 bound to 25-hydroxycholesterol (25HC), the structure and regulatory ...
Renhong Yan +7 more
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Enhancer of zeste homolog 2 enhances the migration and chemotaxis of dental mesenchymal stem cells
Journal of International Medical Research, 2020 Objective To investigate the function of enhancer of zeste homolog 2 (EZH2) in the migration and chemotaxis of human dental tissue-derived mesenchymal stem cells. Methods The expression of EZH2, C-X-C motif chemokine ligand 11 (CXCL11), CXCL16, and CXCR1
Huarui Ma +6 more
doaj +1 more source
Astronomy & Geophysics, 2000 Mike Bode, Phil Charles and Carlos Frenk report on a Standing Conference of Astronomy Professors meeting to consider the UK–ESO question, held at the Royal Astronomical Society on 22 June 2000.
openaire +1 more source
Cells, 2019 : Stem cells isolated from the apical papilla of wisdom teeth (SCAPs) are an attractive model for tissue repair due to their availability, high proliferation rate and potential to differentiate in vitro towards mesodermal and neurogenic lineages.
Murielle Rémy +8 more
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