Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen [PDF]
Nature Communications, 2023 The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C.
Chinaemerem U. Onyishi +10 more
doaj +5 more sources
The Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors [PDF]
Frontiers in Immunology, 2015 The class A Scavenger Receptor (cA-SR) family is a group of five evolutionarily related innate immune receptors. The cA-SRs are known for their promiscuous ligand binding; as they have been shown to bind bacteria such as Streptococcus pneumoniae, and ...
Nicholas eYap +3 more
doaj +5 more sources
Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor. [PDF]
PLoS Pathogens, 2018 Macrophages are a diverse group of phagocytic cells acting in host protection against stress, injury, and pathogens. Here, we show that the scavenger receptor SR-A6 is an entry receptor for human adenoviruses in murine alveolar macrophage-like MPI cells,
Nicole Stichling +13 more
doaj +9 more sources
Standardizing Scavenger Receptor Nomenclature [PDF]
The Journal of Immunology, 2014 Abstract Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a variety of ligands, including endogenous and modified host-derived molecules and microbial pathogens.
M. Prabhudas +14 more
semanticscholar +4 more sources
Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice [PDF]
Journal of Lipid Research, 2000 Scavenger receptors, which include various classes, play an important role in atherogenesis by mediating the unrestricted uptake of modified lipoproteins, resulting in the massive accumulation of cholesteryl esters.
Nicole Herijgers +6 more
doaj +2 more sources
Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
Nature Communications, 2017 Scavenger receptors can function as pattern recognition receptors to sense infection. Here the authors show that, in response to worm and bacterial infection, scavenger receptor class A prevents nuclear localization of IRF5 and thereby drives M2 ...
Zhipeng Xu +15 more
doaj +2 more sources
Scavenger receptors in host defense: from functional aspects to mode of action
Cell Communication and Signaling, 2022 Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous and encompass the miscellaneous group of transmembrane proteins and soluble secretory extracellular domain.
Qamar Taban +4 more
doaj +2 more sources
A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake1 [PDF]
Journal of Lipid Research, 1998 The class A macrophage scavenger receptors (SR-A) are macrophage-specific trimeric integral membrane glycoproteins that have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's ...
Peter J. Gough +2 more
doaj +2 more sources
Scavenger receptor-BI is a receptor for lipoprotein(a)
Journal of Lipid Research, 2013 Scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that binds a variety of lipoproteins, including high density lipoprotein (HDL) and low density lipoprotein (LDL), but lipoprotein(a) [Lp(a)] has not been investigated as a possible ...
Xiao-Ping Yang +9 more
doaj +2 more sources
Activated scavenger receptor A promotes glial internalization of aβ. [PDF]
PLoS ONE, 2014 Beta-amyloid (Aβ) aggregates have a pivotal role in pathological processing of Alzheimer's disease (AD). The clearance of Aβ monomer or aggregates is a causal strategy for AD treatment.
He Zhang +6 more
doaj +2 more sources