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The Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors [PDF]
Frontiers in Immunology, 2015 The class A Scavenger Receptor (cA-SR) family is a group of five evolutionarily related innate immune receptors. The cA-SRs are known for their promiscuous ligand binding; as they have been shown to bind bacteria such as Streptococcus pneumoniae, and ...
Nicholas eYap +3 more
doaj +6 more sources
Scavenger receptor-BI is a receptor for lipoprotein(a) [PDF]
Journal of Lipid Research, 2013 Scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that binds a variety of lipoproteins, including high density lipoprotein (HDL) and low density lipoprotein (LDL), but lipoprotein(a) [Lp(a)] has not been investigated as a possible ...
Xiao-Ping Yang +9 more
doaj +5 more sources
The evolution of the class A scavenger receptors [PDF]
BMC Evolutionary Biology, 2012 Background The class A scavenger receptors are a subclass of a diverse family of proteins defined based on their ability to bind modified lipoproteins. The 5 members of this family are strikingly variable in their protein structure and function, raising ...
Whelan Fiona J +4 more
doaj +5 more sources
The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer. [PDF]
Front Immunol, 2022 Macrophage scavenger receptor 1 (MSR1), also named CD204, holds key inflammatory roles in multiple pathophysiologic processes. Present primarily on the surface of various types of macrophage, this receptor variably affects processes such as ...
Gudgeon J, Marín-Rubio JL, Trost M.
europepmc +2 more sources
Standardizing Scavenger Receptor Nomenclature [PDF]
The Journal of Immunology, 2014 Abstract Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a variety of ligands, including endogenous and modified host-derived molecules and microbial pathogens.
M. PrabhuDas +14 more
semanticscholar +4 more sources
Journal of Lipid Research, 1981 Improved techniques of cell isolation resulted in 90 to 100 million monocytes from a single donor. Addition of low density lipoprotein (LDL) to to cultures of these cells resulted in the down regulation of LDL receptor activity.
A M Fogelman +4 more
doaj +2 more sources
Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
Nature Communications, 2017 Scavenger receptors can function as pattern recognition receptors to sense infection. Here the authors show that, in response to worm and bacterial infection, scavenger receptor class A prevents nuclear localization of IRF5 and thereby drives M2 ...
Zhipeng Xu +15 more
doaj +2 more sources
Scavenger receptors in host defense: from functional aspects to mode of action
Cell Communication and Signaling, 2022 Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous and encompass the miscellaneous group of transmembrane proteins and soluble secretory extracellular domain.
Qamar Taban +4 more
doaj +2 more sources
Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen [PDF]
Nature Communications, 2023 The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C.
Chinaemerem U. Onyishi +10 more
doaj +2 more sources
CD36, a scavenger receptor implicated in atherosclerosis [PDF]
Experimental & Molecular Medicine, 2014 CD36 is a membrane glycoprotein that is present on various types of cells, including monocytes, macrophages, microvascular endothelial cells, adipocytes and platelets.
Young Mi Park
semanticscholar +4 more sources