Results 1 to 10 of about 68,524 (331)

The evolution of the class A scavenger receptors [PDF]

BMC Evolutionary Biology, 2012
Background The class A scavenger receptors are a subclass of a diverse family of proteins defined based on their ability to bind modified lipoproteins. The 5 members of this family are strikingly variable in their protein structure and function, raising ...
Whelan Fiona J, Meehan Conor J, Golding G Brian, McConkey Brendan J, E Bowdish Dawn M   +4 more
doaj   +5 more sources

Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages.

Journal of Lipid Research, 1981
Improved techniques of cell isolation resulted in 90 to 100 million monocytes from a single donor. Addition of low density lipoprotein (LDL) to to cultures of these cells resulted in the down regulation of LDL receptor activity.
A M Fogelman, M E Haberland, J Seager, M Hokom, P A Edwards   +4 more
doaj   +2 more sources

The Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors [PDF]

Frontiers in Immunology, 2015
The class A Scavenger Receptor (cA-SR) family is a group of five evolutionarily related innate immune receptors. The cA-SRs are known for their promiscuous ligand binding; as they have been shown to bind bacteria such as Streptococcus pneumoniae, and ...
Nicholas eYap, Fiona Jane Whelan, Dawn M.E. Bowdish, Brian eGolding   +3 more
doaj   +5 more sources

Scavenger receptor-BI is a receptor for lipoprotein(a) [PDF]

Journal of Lipid Research, 2013
Scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that binds a variety of lipoproteins, including high density lipoprotein (HDL) and low density lipoprotein (LDL), but lipoprotein(a) [Lp(a)] has not been investigated as a possible ...
Xiao-Ping Yang, Marcelo J. Amar, Boris Vaisman, Alexander V. Bocharov, Tatyana G. Vishnyakova, Lita A. Freeman, Roger J. Kurlander, Amy P. Patterson, Lewis C. Becker, Alan T. Remaley   +9 more
doaj   +4 more sources

Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen [PDF]

Nature Communications, 2023
The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C.
Chinaemerem U. Onyishi, Guillaume E. Desanti, Alex L. Wilkinson, Samuel Lara-Reyna, Eva-Maria Frickel, Gyorgy Fejer, Olivier D. Christophe, Clare E. Bryant, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May   +10 more
doaj   +2 more sources

Scavenger Receptor C1 Mediates Toxicity of Binary Toxin from Lysinibacillus sphaericus to Ag55 Cells [PDF]

Toxins
Lysinibacillus sphaericus harboring Binary (BinA and BinB) toxins is highly toxic against Anopheles and Culex mosquito larvae. The Anopheles Ag55 cell line is a suitable model for investigating the mode of Bin toxin action.
Qi Zhang, Gang Hua, Laramie Smith, Michael J. Adang   +3 more
doaj   +2 more sources

Macrophage Scavenger Receptor Class A [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2000
Abstract —In atherogenesis, elevated plasma levels of low density lipoprotein (LDL) lead to the chronic presence of LDL in the arterial wall. There, LDL is modified (eg, oxidized), and these modified lipoproteins activate endothelial cells, which attract circulating monocytes.
M.P.J. de Winther, K.W. van Dijk, Louis M. Havekes, Marten H. Hofker   +3 more
openaire   +4 more sources

Scavenger receptors [PDF]

Current Biology, 2020
Scavenger receptors (SRs) are a large family of cell-surface receptors that are diverse in their structure and biological function and are divided into different classes. SRs can bind to a range of ligands and enhance the elimination of altered-self or non-self targets.
Ali, Alquraini, Joseph, El Khoury
openaire   +2 more sources

Extensive diet-induced atherosclerosis in scavenger receptor class B type 1-deficient mice is associated with substantial leukocytosis and elevated vascular cell adhesion molecule-1 expression in coronary artery endothelium

Frontiers in Physiology, 2023
High levels of low density lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol are risk factors for cardiovascular disease. Mice that lack genes involved in the clearance of LDL from the bloodstream, such as the LDL
Mark T. Fuller, Mark T. Fuller, Omid Dadoo, Omid Dadoo, Ting Xiong, Ting Xiong, Pardh Chivukula, Pardh Chivukula, Melissa E. MacDonald, Samuel K. Lee, Samuel K. Lee, Richard C. Austin, Richard C. Austin, Suleiman A. Igdoura, Bernardo L. Trigatti, Bernardo L. Trigatti   +15 more
doaj   +1 more source

Standardizing Scavenger Receptor Nomenclature [PDF]

The Journal of Immunology, 2014
Abstract Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a variety of ligands, including endogenous and modified host-derived molecules and microbial pathogens.
PrabhuDas, Mercy, Bowdish, Dawn, Drickamer, Kurt, Febbraio, Maria, Herz, Joachim, Kobzik, Lester, Krieger, Monty, Loike, John D., Means, Terry K., Moestrup, Soren K., Post, Steven, Sawamura, Tatsuya, Silverstein, Samuel C., Wang, Xiang-Yang, El Khoury, Joseph   +14 more
openaire   +3 more sources