Results 41 to 50 of about 2,493,460 (390)
Cell density can affect cholesteryl ester accumulation in the human THP-1 macrophage.
Journal of Lipid Research, 1994 Esterified cholesterol (EC) accumulation was induced in THP-1 macrophages after exposure to acetylated LDL (acLDL), and the extent of accumulation was dependent on cell density.
A Rodriguez +3 more
doaj +1 more source
Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1
MicrobiologyOpen, 2019 The histamine H2 receptor (H2R) is a G protein‐coupled receptor that mediates cyclic AMP production, protein kinase A activation, and MAP kinase signaling.
Robert Fultz +9 more
doaj +1 more source
Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages
Journal of Lipid Research, 2012 Scavenger receptor BI (SR-BI), an HDL receptor, plays a key role in reverse cholesterol transport. In mice, disruption of SR-BI results in hypersensitivity to lipopolysaccharide (LPS) and bacteria-induced septic shock due to adrenal insufficiency and ...
Lei Cai +4 more
doaj +1 more source
High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell Proliferation [PDF]
, 2018 Recent evidence suggests that oxidative stress can play a role in the pathogenesis and the progression of prostate cancer (PCa). Reactive oxygen species (ROS) generation is higher in PCa cells compared to normal prostate epithelial cells and this ...
Botta, Margherita +8 more
core +2 more sources
Theranostics, 2017 Rheumatoid arthritis (RA) is a chronic autoimmune disorder implicated in multiple joint affection and even disability. The activated macrophages perform a predominant role in onset and persistence of RA.
Modi Yang +7 more
semanticscholar +1 more source
Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]
, 2012 BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman +8 more
core +2 more sources
Scavenger receptors in atherosclerosis [PDF]
Current Opinion in Hematology, 1997 Membership in the broad family of scavenger receptors has grown significantly. Two new scavenger receptor receptors have been cloned (SR-BI and SR-CI) and a previously isolated integral membrane protein (CD36) has been found to possess lipoprotein binding properties that entitle it to be included in the family. The breadth of ligand recognition of this
openaire +2 more sources
Modulation of macrophage scavenger receptor transport by protein phosphorylation
Journal of Lipid Research, 1996 The identification of three highly conserved phosphorylation sites in the cytoplasmic domain of each of the monomeric subunits of the macrophage scavenger receptor suggests that protein phosphorylation may regulate this receptor pathway.
L G Fong
doaj +1 more source
Current Issues in Molecular Biology, 2022 This study aimed to compare tissue levels of CD80 (pro-inflammatory macrophage-related surface marker), CD163, and CD206 (anti-inflammatory macrophage-related surface markers), and their ratios in periodontal and peri-implant health and disease ...
Mustafa Yilmaz +4 more
doaj +1 more source
P2X7 as a scavenger receptor for innate phagocytosis in the brain
British Journal of Pharmacology, 2018 The P2X7 receptor has been widely studied for its ATP‐induced pro‐inflammatory effect, but in the absence of a ligand, P2X7 has a second function as a scavenger receptor, which is active in the development of the human brain.
B. Gu, J. Wiley
semanticscholar +1 more source