Results 121 to 130 of about 25,031 (241)

The rRole of Intestinal Scavenger Receptor Class B Type I in Chylomicron Production in Normal and Insulin Resistant States

, 2013
In recent years, studies have revealed a central role for the intestine in regulation of lipid homeostasis and development of insulin resistance and type-2 diabetes. The function of intestinal Scavenger Receptor Class-B type-I remains unknown, however it
Lino, Marsel
core   +1 more source

ANALYSIS OF CELLULAR SENTINELS FOR EXTRACELLULAR HEAT SHOCK PROTEIN-PEPTIDE COMPLEXES [PDF]

, 2013
Since the discovery of gp96 in the 1980’s as a “tumor rejection antigen,” Heat Shock Proteins (HSPs) have received attention from immunologists for their ability to prime immune responses.
Messmer, Michelle
core  

Differential roles of Scavenger receptor class B type I: A protective molecule and a facilitator of atherosclerosis (Review). [PDF]

Mol Med Rep, 2020
Ma B, Jia J, Wang X, Zhang R, Niu S, Ni L, Di X, Liu C.   +7 more
europepmc   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Scavenger receptor class B type i (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model

, 2010
Scavenger receptor class B type I (SR-BI) is a high-density lipoprotein receptor that regulates cholesterol efflux fromthe peripheral tissues to the liver.
Georgopoulos, S., Thanopoulou, K., Fragkouli, A., Stylianopoulou, F.   +3 more
core   +2 more sources

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

Studies on scavenger receptor class B type I and genes implicated in foam cell formation

, 2001
The risk of atherosclerosis correlates with plasma levels of low-density lipoprotein (LDL) cholesterol and is inversely correlated to plasma levels of high-density lipoprotein (HDL) cholesterol.
Svensson, Per-Arne 1969-
core  

High density lipoproteins facilitate hepatitis C virus entry through the scavenger receptor class B type I.

, 2005
The scavenger receptor class B type I (SR-BI) has recently been shown to interact with hepatitis C virus (HCV) envelope glycoprotein E2, suggesting that it might be involved at some step of HCV entry into host cells. However, due to the absence of a cell
Jean Dubuisson, Ngoc Vu-Dac, Cécile Voisset, Voisset, Cécile, Op De Beeck, Anne, Emmanuelle Blanchard, Nathalie Callens, Dubuisson, Jean, Callens, Nathalie, Blanchard, Emmanuelle, Anne Op De Beeck, Vu-Dac, Ngoc, Dubuisson, J   +12 more
core   +1 more source