Results 221 to 230 of about 20,902 (246)
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Class B Scavenger Receptors, Caveolae and Cholesterol Homeostasis
Trends in Cardiovascular Medicine, 1999Class B scavenger receptors are predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. Caveolae and their associated protein, caveolin, have been implicated in cholesterol trafficking and in the regulation of cellular cholesterol homeostasis. Recent studies indicate that scavenger receptor,
Sergey V. Matveev +2 more
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The cellular biology of scavenger receptor class B type I
Current Opinion in Lipidology, 2001The HDL receptor scavenger receptor class B type I plays an important role in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. However, the mechanism by which scavenger receptor class B type I mediates selective cholesterol uptake is unclear.
David L. Silver, Alan R. Tall
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Role of CD36, the Macrophage Class B Scavenger Receptor, in Atherosclerosis
Annals of the New York Academy of Sciences, 2001Abstract: Recent work in the field of atherosclerosis has greatly expanded our knowledge of the pathogenesis of this disease. Scavenger receptors, including CD36, are thought to be most important early in the disease progression during macrophage uptake of modified LDL and foam cell formation.
Roy L. Silversterin +4 more
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Scavenger receptor class B type I and immune dysfunctions
Current Opinion in Endocrinology, Diabetes & Obesity, 2014To summarize the recent findings about the roles of scavenger receptor class B type I (SR-BI) in immunity and discuss the underlying mechanisms by which SR-BI prevents immune dysfunctions.SR-BI is well known as a high-density lipoprotein (HDL) receptor playing key roles in HDL metabolism and in protection against atherosclerosis.
Zhong Zheng, Junting Ai, Xiang-An Li
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CD36 in Atherosclerosis: The Role of a Class B Macrophage Scavenger Receptor
Annals of the New York Academy of Sciences, 2000Abstract: CD36, an 88 kD transmembrane glycoprotein, is an important receptor for oxidized lipoproteins. Unlike the LDL receptor, expression of CD36 is upregulated by this pro‐atherogenic particle, and binding and uptake perpetuates a cycle of lipid accumulation and receptor expression.
David P. Hajjar +4 more
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Functions of scavenger receptor class B, type I in atherosclerosis
Current Opinion in Lipidology, 2012This review highlights the diverse roles of the high-affinity HDL receptor scavenger receptor class B, type I (SR-BI) in the modulation of global cholesterol homeostasis and vascular cell function, and the potential implications of these processes in atherosclerosis.SR-BI in the liver plays a critical role in reverse cholesterol transport and it ...
Chieko Mineo, Philip W. Shaul
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HDL scavenger receptor class B type I and platelet function
Current Opinion in Lipidology, 2011HDL cholesterol levels have been inversely correlated with thrombosis and HDL has been shown to mediate various antithrombotic effects. However, molecular mechanisms underlying the suppressing effect of HDL on platelet reactivity are not completely understood.
Jerzy-Roch Nofer, Miranda Van Eck
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Uptake and fate of class B scavenger receptor ligands in HepG2 cells
European Journal of Biochemistry, 1999Class B scavenger receptors (SR‐Bs) interact with native, acetylated and oxidized low‐density lipoprotein (LDL, AcLDL and OxLDL), high‐density lipoprotein (HDL3) and maleylated BSA (M‐BSA). The aim of this study was to analyze the catabolism of CD36‐ and LIMPII‐analogous‐1 (CLA‐1), the human orthologue for the scavenger receptor class B type I (SR‐BI),
Louise Falstrault +3 more
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HDL and Scavenger Receptor Class B Type I (SRBI)
2022The scavenger receptor class B type I (SR-BI) is a versatile HDL receptor protein. It is highly expressed in liver and steroidogenic tissues. SR-BI regulates selective uptake of cholesterol ester (CE) from HDL, revealing its role in mediating reverse cholesterol transport (RCT) and steroid hormone synthesis.
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Scavenger Receptor Class B, Type I: A Promising Immunotherapy Target
Immunotherapy, 2011Scavenger receptor class B, type I (SR-BI) is a crucial molecule in lipid metabolism, since the interaction of high-density lipoproteins (HDLs) with SR-BI is involved in reverse cholesterol transport and cholesterol efflux. Recent findings also underscore a critical role of SR-BI in antimicrobial and immune responses. SR-BI is not only highly expressed
Jessica Fioravanti +2 more
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