Results 221 to 230 of about 22,858 (247)
DNA Flipping as Facile Mechanism for Transmembrane Signaling in Synthetic Cells. [PDF]
Baranda Pellejero L +4 more
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Novel Functions of Endothelial Scavenger Receptor Class B Type I
Current Atherosclerosis Reports, 2021Scavenger receptor class B type I (SR-BI) serves a key role in the reverse cholesterol transport in the liver as the high-affinity receptor for HDL. SR-BI is abundantly expressed in endothelium, and earlier works indicate that the receptor mediates anti-atherogenic actions of HDL. However, more recent studies uncovered novel functions of endothelial SR-
Liming Yu, Yao Dai, Chieko Mineo
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Class B Scavenger Receptors, Caveolae and Cholesterol Homeostasis
Trends in Cardiovascular Medicine, 1999Class B scavenger receptors are predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. Caveolae and their associated protein, caveolin, have been implicated in cholesterol trafficking and in the regulation of cellular cholesterol homeostasis. Recent studies indicate that scavenger receptor,
G A, Graf, S V, Matveev, E J, Smart
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Scavenger receptor class B type I and immune dysfunctions
Current Opinion in Endocrinology, Diabetes & Obesity, 2014To summarize the recent findings about the roles of scavenger receptor class B type I (SR-BI) in immunity and discuss the underlying mechanisms by which SR-BI prevents immune dysfunctions.SR-BI is well known as a high-density lipoprotein (HDL) receptor playing key roles in HDL metabolism and in protection against atherosclerosis.
Zhong, Zheng, Junting, Ai, Xiang-An, Li
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HDL scavenger receptor class B type I and platelet function
Current Opinion in Lipidology, 2011HDL cholesterol levels have been inversely correlated with thrombosis and HDL has been shown to mediate various antithrombotic effects. However, molecular mechanisms underlying the suppressing effect of HDL on platelet reactivity are not completely understood.
Jerzy-Roch, Nofer, Miranda, van Eck
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The cellular biology of scavenger receptor class B type I
Current Opinion in Lipidology, 2001The HDL receptor scavenger receptor class B type I plays an important role in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. However, the mechanism by which scavenger receptor class B type I mediates selective cholesterol uptake is unclear.
D L, Silver, A R, Tall
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HDL and Scavenger Receptor Class B Type I (SRBI)
2022The scavenger receptor class B type I (SR-BI) is a versatile HDL receptor protein. It is highly expressed in liver and steroidogenic tissues. SR-BI regulates selective uptake of cholesterol ester (CE) from HDL, revealing its role in mediating reverse cholesterol transport (RCT) and steroid hormone synthesis.
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Scavenger Receptor Class B, Type I: A Promising Immunotherapy Target
Immunotherapy, 2011Scavenger receptor class B, type I (SR-BI) is a crucial molecule in lipid metabolism, since the interaction of high-density lipoproteins (HDLs) with SR-BI is involved in reverse cholesterol transport and cholesterol efflux. Recent findings also underscore a critical role of SR-BI in antimicrobial and immune responses. SR-BI is not only highly expressed
Jessica, Fioravanti +2 more
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Hyperglycemia suppresses hepatic scavenger receptor class B type I expression
American Journal of Physiology-Endocrinology and Metabolism, 2008Hyperglycemia is a major risk factor for atherosclerotic disease. Hepatic scavenger receptor class B type I (SR-BI) binds HDL particles that mediate reverse cholesterol transport and thus lowers the risk of atherosclerosis. Here we examined glucose regulation of SR-BI gene expression in both HepG2 cells and whole animals. Results showed that hepatic SR-
Koji, Murao +8 more
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