Results 21 to 30 of about 55,768 (280)

The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges

Journal of Lipid Research, 2009
It is now thirty years since the original observation that macrophages take up and degrade modified forms of low density lipoprotein (LDL). Molecular cloning has identified multiple scavenger receptors that can endocytose modified LDL and binding studies
David R. Greaves, Siamon Gordon
doaj   +1 more source

Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease

International Journal of Hypertension, 2010
Scavenger receptors act as membrane-bound and soluble proteins that bind to macromolecular complexes and pathogens. This diverse supergroup of proteins mediates binding to modified lipoprotein particles which regulate the initiation and progression of ...
Sam L. Stephen, Katie Freestone, Sarah Dunn, Michael W. Twigg, Shervanthi Homer-Vanniasinkam, John H. Walker, Stephen B. Wheatcroft, Sreenivasan Ponnambalam   +7 more
doaj   +1 more source

Lipoprotein receptor interactions are not required for monocyte oxidation of LDL.

Journal of Lipid Research, 1995
Upon activation, human peripheral blood monocytes and U937 cells oxidized low density lipoprotein (LDL), converting it to a cytotoxin. The oxidized LDL loses its ability to interact specifically with the native LDL (apoB/E) receptor and becomes a ligand ...
M K Cathcart, Q Li, G M Chisolm, 3rd
doaj   +1 more source

Scavenger receptors in human airway epithelial cells: role in response to double-stranded RNA.

PLoS ONE, 2012
Scavenger receptors and Toll-like receptors (TLRs) cooperate in response to danger signals to adjust the host immune response. The TLR3 agonist double stranded (ds)RNA is an efficient activator of innate signalling in bronchial epithelial cells.
Audrey Dieudonné, David Torres, Simon Blanchard, Solenne Taront, Pascale Jeannin, Yves Delneste, Muriel Pichavant, François Trottein, Philippe Gosset   +8 more
doaj   +1 more source

Protective or deleterious role of scavenger receptors SR-A and CD36 on host resistance to Staphylococcus aureus depends on the site of infection. [PDF]

PLoS ONE, 2014
Staphylococcus aureus is a major human opportunistic pathogen responsible for a broad spectrum of infections ranging from benign skin infection to more severe life threatening disorders (e.g.
Charlène Blanchet, Gregory Jouvion, Catherine Fitting, Jean-Marc Cavaillon, Minou Adib-Conquy   +4 more
doaj   +1 more source

Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors

Journal of Lipid Research, 1993
Macrophage scavenger receptors have been implicated in various macrophage-associated processes, including atherosclerosis and clearance of bacterial endotoxin. They bind to a wide variety of polyanionic ligands and display complex binding characteristics.
J Ashkenas, M Penman, E Vasile, S Acton, M Freeman, M Krieger   +5 more
doaj   +1 more source

Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection

Nature Communications, 2017
Scavenger receptors can function as pattern recognition receptors to sense infection. Here the authors show that, in response to worm and bacterial infection, scavenger receptor class A prevents nuclear localization of IRF5 and thereby drives M2 ...
Zhipeng Xu, Lei Xu, Wei Li, Xin Jin, Xian Song, Xiaojun Chen, Jifeng Zhu, Sha Zhou, Yong Li, Weiwei Zhang, Xiaoxiao Dong, Xiaowei Yang, Feng Liu, Hui Bai, Qi Chen, Chuan Su   +15 more
doaj   +1 more source

Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages.

Journal of Lipid Research, 1981
Improved techniques of cell isolation resulted in 90 to 100 million monocytes from a single donor. Addition of low density lipoprotein (LDL) to to cultures of these cells resulted in the down regulation of LDL receptor activity.
A M Fogelman, M E Haberland, J Seager, M Hokom, P A Edwards   +4 more
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Hydroxychloroquine Effects on THP-1 Macrophage Cholesterol Handling: Cell Culture Studies Corresponding to the TARGET Cardiovascular Trial

Medicina, 2022
Background and Objectives: Cardiovascular (CV) risk is elevated in rheumatoid arthritis (RA). RA patient plasma causes pro-atherogenic derangements in cholesterol transport leading to macrophage foam cell formation (FCF).
Saba Ahmed, Justin Konig, Lora J. Kasselman, Heather A. Renna, Joshua De Leon, Steven E. Carsons, Allison B. Reiss   +6 more
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Scavenger receptors in atherosclerosis [PDF]

Current Opinion in Hematology, 1997
Membership in the broad family of scavenger receptors has grown significantly. Two new scavenger receptor receptors have been cloned (SR-BI and SR-CI) and a previously isolated integral membrane protein (CD36) has been found to possess lipoprotein binding properties that entitle it to be included in the family. The breadth of ligand recognition of this
openaire   +2 more sources