Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models. [PDF]
Acta Pharmacol SinWu J +5 more
europepmc +1 more source
The importance of applied light quality on the production of lignans and phenolic acids in Schisandra chinensis (Turcz.) Baill. cultures in vitro [PDF]
, 2016 Ekiert, Halina, Szopa, Agnieszka
core +1 more source
Improved production of dibenzocyclooctadiene lignans in the elicited microshoot cultures of Schisandra chinensis (Chinese magnolia vine) [PDF]
, 2018 Ekiert, Halina +4 more
core +1 more source
Reflections on the theory of "silver bullet" octreotide tracers: implications for ligand-receptor interactions in the age of peptides, heterodimers, receptor mosaics, truncated receptors, and multifractal analysis [PDF]
, 2011 Roy Moncayo
core +1 more source
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Comparative Effects of Schisandrin A, B, and C on Acne-Related Inflammation
Inflammation, 2017Inflammatory responses induced by Propionibacterium acnes are a major etiological factor in the pathogenesis of acne vulgaris. Schisandrin A, schisandrin B, and schisandrin C are the representative lignans of Schisandra chinensis (Turcz.) Baill. extract.
Miaomiao, Guo +4 more
openaire +4 more sources
Schisandrin B promotes TH1 cell differentiation by targeting STAT1
International Immunopharmacology, 2021Schisandrin B (Sch B) is the major active ingredient of the traditional Chinese medicine Schisandra chinensis and has antitumor activity, anti-inflammatory activity. CD4+ Th subsets orchestrate immune responses to plenty of pathogen infections and participate in the pathogenesis of many immune-related diseases.
Jufeng Guo +4 more
openaire +2 more sources
Separation and purification of (−)schisandrin B from schisandrin B stereoisomers
Biochemical Engineering Journal, 2008Abstract Schisandrin B (Sch B), consisting of a mixture of its stereoisomers, namely (−)Sch B and (±)γ-schisandrin, is the most abundant and biologically active dibenzocyclooctadiene lignan present in Fructus Schisandrae (FS). The objective of this study is to develop a process for large-scale separation and purification of a single stereoisomer of ...
Luk, Ka Fai SENG +2 more
openaire +2 more sources
Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity
Methods and Findings in Experimental and Clinical Pharmacology, 2010Our aim was to investigate the inhibitory effects of schisandrin A and schisandrin B on cytochrome P450 (CYP3A) activity in rat liver microsomes and the mechanism of this interaction. 1'-Hydroxy midazolam and midazolam 1-hydroxylation catalyzed by CYP3A were analyzed by high performance liquid chromatography (HPLC).
W L, Li, H W, Xin, M W, Su, L, Xiong
openaire +2 more sources
Schisandrin B and Other Dibenzocyclooctadiene Lignans
2004Schisandrin B (Sch B, Fig. 1a) is the most abundant dibenzocyclooctadiene derivative (lignan) isolated from Fructus Schisandrae (FS), the fruit of Schisandra chinensis (Turcz.) Baillon, or Wu-Wei-Zi, meaning the fruit of five tastes in Chinese. FS is a commonly used herb in traditional Chinese medicine (TCM).
Robert Kam-Ming Ko, Duncan Mak
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Schisandrin B—A novel inhibitor of P-glycoprotein
Biochemical and Biophysical Research Communications, 2005P-glycoprotein-mediated drug efflux is one of the major causes of the cancer multidrug resistance (MDR). Inhibition of P-glycoprotein could reverse cancer MDR. Here, we show that schisandrin B, a naturally occurring compound from Schisandra chinensis (Turcz.) Baill, bears strong potency to inhibit P-glycoprotein.
Pan, Qiangrong +3 more
openaire +2 more sources