Results 161 to 170 of about 12,357,672 (189)

Inhibitory effect of schisandrin on spontaneous contraction of isolated rat colon. [PDF]

Phytomedicine, 2011
This study examined the effect of schisandrin, one of the major lignans isolated from Schisandra chinensis, on spontaneous contraction in rat colon and its possible mechanisms. Schisandrin produced a concentration-dependent inhibition (EC50 = 1.66 μM) on
Chun-Tao Che, John H K Yeung
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In vivo effect of Schisandrin B on cytochrome P450 enzyme activity

Phytomedicine, 2013
To investigate the possible drug interaction, this study is designed to evaluate the ability of Schisandrin B (Sch B) to modulate cytochrome P450 3A activity (CYP3A) in vivo and to alter the pharmacokinetic profiles of CYP3A substrate (midazolam) in treated rats.
Wei-Liang, Li, Hua-Wen, Xin, Ai-Rong, Yu, Xiao-Chun, Wu   +3 more
openaire   +2 more sources

Schisandrin B targets CD44 to inhibit glioblastoma multiforme

Naunyn-Schmiedeberg's Archives of Pharmacology
Glioblastoma multiforme (GBM), the most common malignant primary brain tumor, responds poorly to surgery, radiotherapy, chemotherapy, and immunotherapy, with dismal prognosis and short median survival. There is an urgent need for improved therapies, with supportive and palliative care integral to the multimodal treatment strategy.
Na, Wang, Yuxin, Xie, Jialin, Chen, Wenpei, Chen, Donghao, Zhang, Hong, Li   +5 more
openaire   +2 more sources

Effects of Schisandrin B and ?-tocopherol on lipid peroxidation, in vitro and in vivo

Molecular and Cellular Biochemistry, 1996
Effects of Schisandrin B (Sch B) and alpha-tocopherol (alpha-TOC) on ferric chloride (Fe3+) induced oxidation of erythrocyte membrane lipids in vitro and carbon tetrachloride (CCl4) induced lipid peroxidation in vivo were examined. While alpha-TOC could produce prooxidant and antioxidant effect on Fe(3+)-induced lipid peroxidation, Sch B only inhibited
Mak, Duncan Hon Fai, Ip, Siu Po, Li, Pui Chun, Poon, Michel Kwong Tat, Ko, Kam Ming   +4 more
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Schisandrin B and Schisandrol B induce mouse CYP2b10 associated with CAR not PXR

Phytochemistry Letters, 2020
Abstract Schisandrin B (SinB) and Schisandrol B (SolB) are two abundant compounds with similar structures in Schisandra sphenanthera widely used for hepatic diseases in Asian countries. They are also pharmacologically active components in many other traditional Chinese medicines.
Minzhu Xie, Jiao Lin, Jinyu Kang, Xiuting Zheng, Kailu Fang, Yishuang Luo, Aiming Liu, Julin Yang   +7 more
openaire   +1 more source

Exploring the Protective Effects of Schisandrin A and Schisandrin B Against Diabetic Cardiomyopathy With a Possible Mechanism Involving Complement Inhibition

Phytotherapy Research
ABSTRACT Schisandra berry , an edible fruit of the Schisandra genus, produces two main lignans known as Schisandrin A (SchA) and Schisandrin B (SchB). These compounds have garnered significant attention for their beneficial effects in alleviating diabetes
Daozheng Fang, Qixiang Shang, Zhihao Liu, Xinyue Li, Quanrun He, Yining Liu, Yong Zhu, Haimeng Li, Tong Wu, Yan‐Fang Xian, Jianping Chen, Jihang Chen   +11 more
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Antioxidant effect of schisandrin B in nervous tissue

2014
Fructus schisandrae (FS), the fruit of Schisandra chinensis, has been used as tonic and sedative in traditional Chinese medicine. Previous studies from our laboratory have demonstrated that schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from FS, could produce antioxidant effect on rodent liver and heart.
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Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling

Chinese Journal of Natural Medicines, 2018
Schisandra chinensis, a traditional Chinese medicine (TCM), has been used to treat sleep disorders. Zebrafish sleep/wake behavioral profiling provides a high-throughput platform to screen chemicals, but has never been used to study extracts and components from TCM.
Jia-Wei, Wang, Feng-Yin, Liang, Xiang-Shuo, Ouyang, Pei-Bo, Li, Zhong, Pei, Wei-Wei, Su   +5 more
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Comparative pharmacokinetics and tissue distribution of schisandrin, deoxyschisandrin and schisandrin B in rats after combining acupuncture and herb medicine (schisandra chinensis)

Biomedical Chromatography, 2014
ABSTRACTRecently, combination therapy with acupuncture and medicine as a practical strategy to treat diseases has gained increasing attention. The present study aimed to investigate whether acupuncture stimulation at ST.36 had a potential impact on the pharmacokinetics and tissue distribution of lignans. An HPLC‐ESI/MS analytical method was established
Xiaoyan, Wu, Yuan, Zhou, Fangzhou, Yin, Guoliang, Dai, Lin, Li, Bin, Xu, De, Ji, Yong, Sun, Chunqin, Mao, Tulin, Lu   +9 more
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Preclinical Concomitant Toxicokinetic Study of Schisandrin B by HPLC–MS/MS

Biomedical Chromatography
ABSTRACTSchisandrin B (Sch B), a natural lignan extracted from schisandra chinesis, has exhibited various pharmacological activities including anticancer effects. However, studies on the preclinical toxicokinetic profile of Sch B have not been publicly reported.
Sanwen Li, Qing Shao, Hongqun Qiao
openaire   +2 more sources