Results 141 to 150 of about 1,905 (169)

Exploring the Protective Effects of Schisandrin A and Schisandrin B Against Diabetic Cardiomyopathy With a Possible Mechanism Involving Complement Inhibition

Phytotherapy Research
ABSTRACT Schisandra berry , an edible fruit of the Schisandra genus, produces two main lignans known as Schisandrin A (SchA) and Schisandrin B (SchB). These compounds have garnered significant attention for their beneficial effects in alleviating diabetes
Daozheng Fang, Qixiang Shang, Zhihao Liu, Xinyue Li, Quanrun He, Yining Liu, Yong Zhu, Haimeng Li, Tong Wu, Yan‐Fang Xian, Jianping Chen, Jihang Chen   +11 more
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Schisandrin B and Schisandrol B induce mouse CYP2b10 associated with CAR not PXR

Phytochemistry Letters, 2020
Abstract Schisandrin B (SinB) and Schisandrol B (SolB) are two abundant compounds with similar structures in Schisandra sphenanthera widely used for hepatic diseases in Asian countries. They are also pharmacologically active components in many other traditional Chinese medicines.
Minzhu Xie, Jiao Lin, Jinyu Kang, Xiuting Zheng, Kailu Fang, Yishuang Luo, Aiming Liu, Julin Yang   +7 more
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Antioxidant effect of schisandrin B in nervous tissue

2014
Fructus schisandrae (FS), the fruit of Schisandra chinensis, has been used as tonic and sedative in traditional Chinese medicine. Previous studies from our laboratory have demonstrated that schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from FS, could produce antioxidant effect on rodent liver and heart.
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Schisandrin B and Alantolactone ameliorates experimental autoimmune encephalomyelitis in mice

The Journal of Immunology, 2020
Abstract Schisandrin B (Sch-B) and Alantolactone (ALT) are two distinct molecules each of which could be extracted from herbs Schisandra chinensis and Inula helenium, respectively, commonly used in traditional Chinese medicine. Previous studies have revealed that both molecules impact STAT3, Nrf2 and Smad-mediated signaling pathways, and
ALTUNTAŞ, HAMİYET, EKEN, AHMET, ÇAKIR, MUSTAFA, KARAYİĞİT, MEHMET ÖNDER   +3 more
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Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling

Chinese Journal of Natural Medicines, 2018
Schisandra chinensis, a traditional Chinese medicine (TCM), has been used to treat sleep disorders. Zebrafish sleep/wake behavioral profiling provides a high-throughput platform to screen chemicals, but has never been used to study extracts and components from TCM.
Jia-Wei, Wang, Feng-Yin, Liang, Xiang-Shuo, Ouyang, Pei-Bo, Li, Zhong, Pei, Wei-Wei, Su   +5 more
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Comparative pharmacokinetics and tissue distribution of schisandrin, deoxyschisandrin and schisandrin B in rats after combining acupuncture and herb medicine (schisandra chinensis)

Biomedical Chromatography, 2014
ABSTRACTRecently, combination therapy with acupuncture and medicine as a practical strategy to treat diseases has gained increasing attention. The present study aimed to investigate whether acupuncture stimulation at ST.36 had a potential impact on the pharmacokinetics and tissue distribution of lignans. An HPLC‐ESI/MS analytical method was established
Xiaoyan, Wu, Yuan, Zhou, Fangzhou, Yin, Guoliang, Dai, Lin, Li, Bin, Xu, De, Ji, Yong, Sun, Chunqin, Mao, Tulin, Lu   +9 more
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Preclinical Concomitant Toxicokinetic Study of Schisandrin B by HPLC–MS/MS

Biomedical Chromatography
ABSTRACTSchisandrin B (Sch B), a natural lignan extracted from schisandra chinesis, has exhibited various pharmacological activities including anticancer effects. However, studies on the preclinical toxicokinetic profile of Sch B have not been publicly reported.
Sanwen Li, Qing Shao, Hongqun Qiao
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Insights Into Anticancer Mechanisms of Schisandrin B: Isolation, Pharmacokinetics, and Preclinical Evidence

Chemistry & Biodiversity
ABSTRACTTraditional medicinal systems in Asian countries revealed the utilization of plant‐based compounds is as old as human civilization. Schisandrin B (SCB), an isolated lignan from the fruit of Schisandra chinensis, is extensively used against different diseases.
Ekta Yadav, Pankaj Kumar Yadav
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Schisandrin B exacerbates acute pancreatitis by driving pathological pancreatic secretion

Biochemical and Biophysical Research Communications
Schisandrin B (SchB), a natural lignan with reported organ-protective effects, was hypothesized to ameliorate severe acute pancreatitis (SAP). We investigated the effects of SchB (30 and 60 mg/kg) in a caerulein-induced mouse model of SAP using histological, biochemical, and transcriptomic analyses.
Jie Ye, Yiting Huang, Xueqiang Liu, Liuyu Lin, Yi Ding   +4 more
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[Schisandrin B prevents doxorubicin-induced cardiotoxicity in rabbits].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2011
To study the effect of dexrazoxane in preventing doxorubicin-induced cardiotoxicity in rabbit-models and its mechanism.Thirty one New Zealand white rabbits were randomly divided into two groups, doxorubicin (DOX) group and doxorubicin + dexrazoxane group.
Fei-Fei, Che, Yu, Liu, Cai-Gang, Xu
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