Results 131 to 140 of about 1,905 (169)

Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity

Methods and Findings in Experimental and Clinical Pharmacology, 2010
Our aim was to investigate the inhibitory effects of schisandrin A and schisandrin B on cytochrome P450 (CYP3A) activity in rat liver microsomes and the mechanism of this interaction. 1'-Hydroxy midazolam and midazolam 1-hydroxylation catalyzed by CYP3A were analyzed by high performance liquid chromatography (HPLC).
W L, Li, H W, Xin, M W, Su, L, Xiong
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Comparative Effects of Schisandrin A, B, and C on Acne-Related Inflammation

Inflammation, 2017
Inflammatory responses induced by Propionibacterium acnes are a major etiological factor in the pathogenesis of acne vulgaris. Schisandrin A, schisandrin B, and schisandrin C are the representative lignans of Schisandra chinensis (Turcz.) Baill. extract.
Miaomiao Guo, Fa-Liang An, Yanhua Lu
exaly   +3 more sources

Schisandrin B and Other Dibenzocyclooctadiene Lignans

2004
Schisandrin B (Sch B, Fig. 1a) is the most abundant dibenzocyclooctadiene derivative (lignan) isolated from Fructus Schisandrae (FS), the fruit of Schisandra chinensis (Turcz.) Baillon, or Wu-Wei-Zi, meaning the fruit of five tastes in Chinese. FS is a commonly used herb in traditional Chinese medicine (TCM).
Robert Kam-Ming Ko, Duncan Mak
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Schisandrin A and B affect the proliferation and differentiation of neural stem cells

Journal of Chemical Neuroanatomy, 2022
Schisandrin A and B (Sch A and B) are the important components of Asian dietary supplement and phytomedicine Schisandra chinensis (S. chinensis). They can enhance adult neurogenesis in vivo; however, these effects still need to be verified. Here NE-4 C neural stem cells (NSCs) were employed as the in vitro model and treated with Sch A and B at 0.1 μg ...
Ning-Ning, Cai, Qi, Geng, Yu, Jiang, Wen-Qian, Zhu, Rui, Yang, Bo-Yang, Zhang, Yu-Feng, Xiao, Bo, Tang, Xue-Ming, Zhang   +8 more
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Schisandrin A and B affect subventricular zone neurogenesis in mouse

European Journal of Pharmacology, 2014
Schisandrin A and B (Sch A and B) are the main effective components extracted from the oriental medicine Schisandra chinensis which is traditionally used to enhance mental and intellectual function. Although their neuroprotective effects have been demonstrated, their influences on neurogenesis are still unknown.
Yi-Xue, Sun, Yan-Long, Cong, Yang, Liu, Bo, Jin, Lu, Si, Ai-Bing, Wang, Huan, Cai, Guan-Yu, Che, Bo, Tang, Chun-Feng, Wang, Zi-Yi, Li, Xue-Ming, Zhang   +11 more
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The synergistic anti-tumor effect of schisandrin B and apatinib

Journal of Asian Natural Products Research, 2019
The synergistic anti-tumor effect of schisandrin B (Sch.B) and apatinib was investigated in vitro. The CCK-8 assay revealed that Sch.B enhanced the inhibition of apatinib on cell proliferation by arresting cell cycle in G0/G1 phase. Sch.B also potentiated the suppression of apatinib on cell migration and invasion, by means of wound-healing and ...
Ya-Jing Li, Hong-Tao Liu, Chao-Jun Xue, Xiao-Qin Xing, Song-Tao Dong, Lin-Shan Wang, Cong-Yang Ding, Lu Meng, Zhan-Jun Dong   +8 more
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Schisandrin A and B enhance the dentate gyrus neurogenesis in mouse hippocampus

Journal of Chemical Neuroanatomy, 2020
Schisandrin A and B (Sch A and B) are the main effective components of Schisandra chinensis (S. chinensis), which is traditionally used to enhance mental and intellectual functions in eastern Asia. Previously, we reported Sch A and B remarkably affect adult neurogenesis in the subventricular zone of mouse lateral ventricle.
Ning-Ning Cai, Zheng-Zhu Wang, Xian-Chun Zhu, Yu Jiang, Wen-Qian Zhu, Rui Yang, Xue-Ming Zhang   +6 more
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In vivo effect of Schisandrin B on cytochrome P450 enzyme activity

Phytomedicine, 2013
To investigate the possible drug interaction, this study is designed to evaluate the ability of Schisandrin B (Sch B) to modulate cytochrome P450 3A activity (CYP3A) in vivo and to alter the pharmacokinetic profiles of CYP3A substrate (midazolam) in treated rats.
Wei-Liang, Li, Hua-Wen, Xin, Ai-Rong, Yu, Xiao-Chun, Wu   +3 more
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The Protective Effects of Tea Polyphenols and Schisandrin B on Nephrotoxicity of Mercury

Biological Trace Element Research, 2011
Mercury (Hg) is an occupational and environmental contaminant that is a well-recognized health hazard. To approach the concrete mechanisms of mercury nephrotoxicity and find out a new way to prevent it, the rats were subcutaneously injected with different dosages of mercuric chloride (HgCl(2))--0, 2.2, 4.4, and 8.8 μmol/kg. The levels of Hg, blood urea
Wei, Liu, Zhaofa, Xu, Haibo, Yang, Yu, Deng, Bin, Xu, Yangang, Wei   +5 more
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Effects of Schisandrin B and ?-tocopherol on lipid peroxidation, in vitro and in vivo

Molecular and Cellular Biochemistry, 1996
Effects of Schisandrin B (Sch B) and alpha-tocopherol (alpha-TOC) on ferric chloride (Fe3+) induced oxidation of erythrocyte membrane lipids in vitro and carbon tetrachloride (CCl4) induced lipid peroxidation in vivo were examined. While alpha-TOC could produce prooxidant and antioxidant effect on Fe(3+)-induced lipid peroxidation, Sch B only inhibited
Mak, Duncan Hon Fai, Ip, Siu Po, Li, Pui Chun, Poon, Michel Kwong Tat, Ko, Kam Ming   +4 more
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