Results 11 to 20 of about 78,832 (263)

Gender-related differences in prevalence, intensity and associated risk factors of Schistosoma infections in Africa: A systematic review and meta-analysis

PLoS Neglected Tropical Diseases, 2021
Background Schistosomiasis remains a global-health problem with over 90% of its burden concentrated in Africa. Field studies reflect the complex ways in which socio-cultural and socio-economic variables, affect the distribution of Schistosoma infections ...
D. Ayabina, Jessica Clark, Helen Bayley, P. Lamberton, Jaspreet Toor, T. Hollingsworth   +5 more
semanticscholar   +1 more source

Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates. [PDF]

Protein Sci
Abstract Schistosomiasis, a neglected tropical disease infecting over 200 million people globally, has limited therapeutic options. The 20S proteasome is a validated drug target for many parasitic infections, including those caused by Plasmodium and Leishmania, and we have previously demonstrated antischistosomal activity with inhibitors targeting ...
Silva EB, Jiang Z, Liu C, Fajtová P, Teixeira TR, de Castro Fiorini Maia G, Liu LJ, El-Sakkary N, Skinner DE, Syed A, Wang SC, Caffrey CR, O'Donoghue AJ.   +12 more
europepmc   +2 more sources

Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis

PLoS Neglected Tropical Diseases, 2021
Schistosomes cause schistosomiasis, the world’s second most important parasitic disease after malaria in terms of public health and social-economic impacts.
J. Kincaid-Smith, A. Tracey, Ronaldo de Carvalho Augusto, I. Bulla, N. Holroyd, A. Rognon, O. Rey, C. Chaparro, A. Oleaga, S. Mas‐Coma, J. Allienne, C. Grunau, M. Berriman, J. Boissier, E. Toulza   +14 more
semanticscholar   +1 more source

Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal

Microorganisms, 2021
Hybridization of infectious agents is a major emerging public and veterinary health concern at the interface of evolution, epidemiology, and control.
C. Fall, S. Lambert, E. Léger, Lucy Yasenev, A. Garba, S. Diop, A. Borlase, S. Catalano, B. Faye, M. Walker, Mariama Sène, J. Webster   +11 more
semanticscholar   +1 more source

Focal eosinophilic infiltration of the liver, benign or malignant?

Clinical Case Reports, 2021
Focal eosinophilic infiltration (FEI) of the liver shares imaging characteristics with malignant hepatic lesions but should be suspected when concomitantly observing eosinophilia. While in itself benign, the cause of FEI should be sought and treated.
Wouter Claeys, Anke Delie, Peter Smeets, Marie‐Angelique De Scheerder, Helena Degroote, Xavier Verhelst, Hans Van Vlierberghe, Anja Geerts   +7 more
doaj   +1 more source

Circulating Anodic Antigen (CAA): A Highly Sensitive Diagnostic Biomarker to Detect Active Schistosoma Infections—Improvement and Use during SCORE

American Journal of Tropical Medicine and Hygiene, 2020
. The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was funded in 2008 to conduct research that would support country schistosomiasis control programs. As schistosomiasis prevalence decreases in many places and elimination is
P. Corstjens, C. de Dood, S. Knopp, Michelle N Clements, G. Ortu, I. Umulisa, E. Ruberanziza, U. Wittmann, T. Kariuki, P. LoVerde, W. Secor, Lydia S. Atkins, S. Kinung’hi, S. Binder, C. Campbell, D. Colley, G. V. van Dam   +16 more
semanticscholar   +1 more source

Impact of Different Mass Drug Administration Strategies for Gaining and Sustaining Control of Schistosoma mansoni and Schistosoma haematobium Infection in Africa

American Journal of Tropical Medicine and Hygiene, 2020
. This report summarizes the design and outcomes of randomized controlled operational research trials performed by the Bill & Melinda Gates Foundation–funded Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) from 2009 to 2019 ...

semanticscholar   +1 more source

A novel, non-neuronal acetylcholinesterase of schistosome parasites is essential for definitive host infection

Frontiers in Immunology, 2023
Schistosomes are long-lived parasitic worms that infect >200 million people globally. The intravascular life stages are known to display acetylcholinesterase (AChE) activity internally as well as, somewhat surprisingly, on external tegumental ...
Patrick J. Skelly, Akram A. Da’dara
doaj   +1 more source

Functional Annotation of Some Hypothetical Genes in the Schistosoma Parasite Based on Reciprocal Best Structural-hit Relationship [PDF]

Research in Molecular Medicine, 2022
Background: The Schistosoma parasite is responsible for several overlooked tropical diseases, which cause significant economic losses in livestock. This parasite is increasingly found in the central areas of the northern provinces of Iran. To generate an
Arezou Askari Rad, Jamal Fayazi, Mohammad Taghi Beigi Nassiri, Alireza Hasani Baferani   +3 more
doaj  

Schistosomiasis and liver disease: Learning from the past to understand the present

Clinical Case Reports, 2020
To diagnose schistosomiasis, past medical history review should include recent travel to or from an endemic area, a history of elevated liver enzymes as well as contact with contaminated sources of water or farm animals.
Eman Abdelghani, Rommel Zerpa, Gloria Iliescu, Carmen P. Escalante   +3 more
doaj   +1 more source