Results 21 to 30 of about 78,832 (263)

First international external quality assessment scheme of nucleic acid amplification tests for the detection of Schistosoma and soil-transmitted helminths, including Strongyloides: A pilot study

PLoS Neglected Tropical Diseases, 2020
Background Nucleic acid amplification tests (NAATs) are increasingly being used as diagnostic tools for soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris trichiura, Necator americanus, Ancylostoma duodenale and A.
P. Cools, L. van Lieshout, R. Koelewijn, D. Addiss, S. Ajjampur, Mio Ayana, R. Bradbury, J. Cantera, D. Dana, K. Fischer, Rubina Imtiaz, J. Kabagenyi, J. Lok, J. McCarthy, Rojelio Mejia, Z. Mekonnen, S. Njenga, N. Othman, H. Shao, R. Traub, M. van Esbroeck, J. Vercruysse, J. Vlaminck, Steven A. Williams, J. Verweij, J. V. van Hellemond, B. Levecke   +26 more
semanticscholar   +1 more source

Schistosome Vaccine Adjuvants in Preclinical and Clinical Research

Vaccines, 2014
There is currently no vaccine available for human use for any parasitic infections, including the helminth disease, schistosomiasis. Despite many researchers working towards this goal, one of the focuses has been on identifying new antigenic targets. The
Rachel Stephenson, Hong You, Donald P. McManus, Istvan Toth   +3 more
doaj   +1 more source

Interactions between Schistosoma haematobium group species and their Bulinus spp. intermediate hosts along the Niger River Valley

Parasites & Vectors, 2020
Urogenital schistosomiasis, caused by infection with Schistosoma haematobium, is endemic in Niger but complicated by the presence of Schistosoma bovis, Schistosoma curassoni and S.
T. Pennance, F. Allan, A. Emery, M. Rabone, J. Cable, A. Garba, A. Hamidou, J. Webster, D. Rollinson, B. Webster   +9 more
semanticscholar   +1 more source

Schistosomal Lipids Activate Human Eosinophils via Toll-Like Receptor 2 and PGD2 Receptors: 15-LO Role in Cytokine Secretion

Frontiers in Immunology, 2019
Parasite-derived lipids may play important roles in host-pathogen interactions and immune evasion mechanisms. Remarkable accumulation of eosinophils is a characteristic feature of inflammation associated with parasitic disease, especially caused by ...
Kelly G. Magalhães, Kelly G. Magalhães, Tatiana Luna-Gomes, Tatiana Luna-Gomes, Fabio Mesquita-Santos, Fabio Mesquita-Santos, Rafael Corrêa, Leonardo Santos Assunção, Georgia Correa Atella, Peter F. Weller, Christianne Bandeira-Melo, Patricia T. Bozza   +11 more
doaj   +1 more source

The essential schistosome tegumental ectoenzyme SmNPP5 can block NAD-induced T cell apoptosis

Virulence, 2020
Infection with intravascular platyhelminths of the genus Schistosoma can result in the debilitating disease schistosomiasis. Schistosomes (blood flukes) can survive in the host for many years.
Catherine S. Nation, Akram A. Da’Dara, Patrick J. Skelly   +2 more
doaj   +1 more source

Concomitant Immunity and Worm Senescence May Drive Schistosomiasis Epidemiological Patterns: An Eco-Evolutionary Perspective

Frontiers in Immunology, 2020
In areas where human schistosomiasis is endemic, infection prevalence and egg output are known to rise rapidly through childhood, reach a peak at 8–15 years of age, and decline thereafter.
Julia C. Buck, Giulio A. De Leo, Giulio A. De Leo, Susanne H. Sokolow, Susanne H. Sokolow   +4 more
doaj   +1 more source

Development of a Molecular Snail Xenomonitoring Assay to Detect Schistosoma haematobium and Schistosoma bovis Infections in their Bulinus Snail Hosts

Molecules, 2020
Schistosomiasis, a neglected tropical disease of medical and veterinary importance, transmitted through specific freshwater snail intermediate hosts, is targeted for elimination in several endemic regions in sub-Saharan Africa. Multi-disciplinary methods
T. Pennance, J. Archer, E. Lugli, Penelope Rostron, Felix Llanwarne, S. Ali, A. K. Amour, K. Suleiman, Sarah Li, D. Rollinson, J. Cable, S. Knopp, F. Allan, S. Ame, B. Webster   +14 more
semanticscholar   +1 more source

Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale

Scientific Reports, 2020
Schistosoma spindale and Schistosoma indicum are ruminant-infecting trematodes of the Schistosoma indicum group that are widespread across Southeast Asia.
Ben P. Jones, Billie F. Norman, Hannah E. Borrett, S. Attwood, M. M. Mondal, Anthony J. Walker, J. P. Webster, P. R. V. Jayanthe Rajapakse, S. Lawton   +8 more
semanticscholar   +1 more source

Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

eLife, 2019
CRISPR/Cas9-based genome editing has yet to be reported in species of the Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma mansoni as proof of principle.
W. Ittiprasert, V. Mann, Shannon E. Karinshak, Avril Coghlan, G. Rinaldi, Geetha Sankaranarayanan, Apisit Chaidee, Toshihiko Tanno, C. Kumkhaek, P. Prangtaworn, Margaret M. Mentink-Kane, Christina J Cochran, P. Driguez, N. Holroyd, A. Tracey, Rutchanee Rodpai, B. Everts, C. Hokke, K. Hoffmann, M. Berriman, P. Brindley   +20 more
semanticscholar   +1 more source

Granuloma formation and tissue pathology in Schistosoma japonicum versus Schistosoma mansoni infections

Parasite immunology (Print), 2020
Schistosomiasis is the most important helminth disease in the world from a public health perspective. S mansoni and S japonicum account for the majority of global intestinal schistosomiasis cases, and the pathogenesis is widely assumed to be ...
Felix Llanwarne, H. Helmby
semanticscholar   +1 more source