Results 51 to 60 of about 80,911 (264)

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Schistosoma japonicum-Associated Colorectal Cancer: A Review.

American Journal of Tropical Medicine and Hygiene, 2019
Schistosoma japonicum is a digenetic blood fluke that has been implicated in the carcinogenesis of several human malignancies, notably liver and colorectal cancer (CRC). Schistosoma japonicum-associated colorectal cancer (SACC) is a distinct subtype with
H. Hamid
semanticscholar   +1 more source

HIV-1 Viral Loads Are Not Elevated in Individuals Co-infected With Schistosoma spp. After Adjustment for Duration of HIV-1 Infection

Frontiers in Immunology, 2018
Studies of the role of Schistosoma co-infections on plasma HIV-1 RNA (HIV-1 viral load) have yielded incongruent results. The role of duration of HIV-1 infection on the link between Schistosoma and HIV-1 viral load has not been previously investigated ...
Soledad Colombe, Paul L. A. M. Corstjens, Claudia J. de Dood, Donald Miyaye, Ruth G. Magawa, Julius Mngara, Samuel E. Kalluvya, Lisette van Lieshout, Govert J. van Dam, Jennifer A. Downs, Jennifer A. Downs   +10 more
doaj   +1 more source

Profiling a Neo‐Antigen‐Driven Immune Response in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Study of the KLH Challenge Model

Clinical Pharmacology &Therapeutics, EarlyView.
Novel compounds targeting the adaptive immune system are commonly initially investigated in healthy volunteers (HV). HV frequently lack constitutively expressed drug‐target engagement biomarkers, complicating the evaluation of pharmacological activity. The keyhole limpet hemocyanin (KLH) neo‐antigen challenge elicits a controlled immune response in HV ...
Micha N. Ronner, Hendrika W. Grievink, Mahdi Saghari, Michelle Osse, Thierry P.P. van den Bosch, Jeffrey Damman, Marieke L. de Kam, Jacobus Burggraaf, Naomi B. Klarenbeek, Manon A. A. Jansen, Matthijs Moerland   +10 more
wiley   +1 more source

Schistosoma Infection and Schistosoma-Derived Products Modulate the Immune Responses Associated with Protection against Type 2 Diabetes

Frontiers in Immunology, 2018
Studies on parasite-induced immunoregulatory mechanisms could contribute to the development of new therapies for inflammatory diseases such as type 2 diabetes (T2D), which is a chronic inflammatory disease characterized by persistent elevated glucose ...
Chun-Lian Tang, Zhi-Ming Liu, Yan Ru Gao, Fei Xiong   +3 more
doaj   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

The Schistosoma Granuloma: Friend or Foe? [PDF]

Frontiers in Immunology, 2013
Infection of man with Schistosoma species of trematode parasite causes marked chronic morbidity. Individuals that become infected with Schistosomes may develop a spectrum of pathology ranging from mild cercarial dermatitis to severe tissue inflammation, in particular within the liver and intestines, which can lead to life threatening hepatosplenomegaly.
Hams E., Aviello G., Fallon P. G.
openaire   +7 more sources

Nanoparticles as Potent Agents for Treatment of Schistosoma Infections: A Systematic Review

Current Therapeutic Research, 2023
: Background: Schistosomiasis is an acute and chronic parasitic disease caused by blood flukes of the genus Schistosoma. The current drugs for treating schistosomiasis are associated with some side effects.
Pegah Shakib, PhD, Masoomeh Zivdari, MSc, Amal Khudair Khalaf, PhD, Abdolrazagh Marzban, PhD, Mazdak Ganjalikhani-Hakemi, PhD, Jahanbakhsh Parvaneh, MD, Hossein Mahmoudvand, PhD, Kourosh Cheraghipour, PhD   +7 more
doaj   +1 more source

Enrichment of Helminth Mitochondrial Genomes From Faecal Samples Using Hybridisation Capture

Molecular Ecology Resources, EarlyView.
ABSTRACT New approaches are urgently needed to enrich rare or low‐abundant DNA in complex samples. Soil‐transmitted helminths (STHs) inhabit heterogeneous environments, including the gastrointestinal tract of their host as adults and are excreted as eggs and larvae in faeces, complicating our understanding of their biology and the use of genetic tools ...
Marina Papaiakovou, Andrea Waeschenbach, Roy M. Anderson, Piet Cools, Zeleke Mekonnen, D. Timothy J. Littlewood, Cinzia Cantacessi, Stephen R. Doyle   +7 more
wiley   +1 more source

SCHISTOSOMIASIS, Hubungan Respon Imun dan Perubahan Patologi

Majalah Kedokteran Andalas, 2011
AbstrakSchistosomiasis merupakan suatu penyakit tropik yang disebabkan oleh cacing genus Schistosoma. Spesies yang dapat menginfeksi manusia antara lain Schistosoma mansoni, Schistosoma japonicum, Schistosoma mekongi, Schistosoma haematobium dan ...
Selfi Renita Rusjdi
doaj   +1 more source