Results 1 to 10 of about 7,564 (137)

RALP1 is essential for schizont maturation and erythrocyte invasion in Plasmodium falciparum [PDF]

Parasites & Vectors
Background Plasmodium falciparum merozoite invasion of erythrocytes is an essential step in the asexual blood-stage cycle and a major target for antimalarial intervention.
Jing Wu, Zuping Zhang, Jiayao Pang, Wenyu Yang, Chandara Ngim, Peiyi Li, Jingru Ye, Bin Tian, Xinyu Cheng, Fei Wang, Qingfeng Zhang, Xiaomin Shang   +11 more
doaj   +2 more sources

Transcription factor 25 modulates gametocytogenesis and ribosome biogenesis in the malaria parasite Plasmodium falciparum [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionPlasmodium falciparum, the causative agent of severe malaria, predominantly reproduces through asexual stages within human red blood cells, with a small subset differentiating into transmissible gametocytes.
Jing Wu, Zuping Zhang, Chandara Ngim, Wenyu Yang, Peiyi Li, Fei Wang, Jingru Ye, Bo Li, Bin Tian, Bin Tian, Qingfeng Zhang, Xiaomin Shang, Xiaomin Shang   +12 more
doaj   +2 more sources

Mid-Liver Stage Arrest of Plasmodium falciparum Schizonts in Primary Porcine Hepatocytes

Frontiers in Cellular and Infection Microbiology, 2022
During co-evolution Plasmodium parasites and vertebrates went through a process of selection resulting in defined and preferred parasite-host combinations.
Saskia C. van der Boor, Geert-Jan van Gemert, Alex E. J. Hanssen, Youri M. van Waardenburg, Matthew B. B. McCall, Teun Bousema, Johannes H. W. de Wilt, Robert W. Sauerwein, Robert W. Sauerwein, Annie S. P. Yang   +9 more
doaj   +1 more source

Evaluation of various sample sources for the cytologic diagnosis of Cytauxzoon felis

Journal of Veterinary Internal Medicine, 2022
Background Cytauxzoon felis is a life‐threatening protozoan disease of cats. Identification of schizont‐laden macrophages is a point‐of‐care diagnostic test for acute cytauxzoonosis.
Casey R. Sleznikow, Jennifer L. Granick, Leah A. Cohn, Laura A. Nafe, Aaron Rendahl, Erin N. Burton   +5 more
doaj   +1 more source

Acute Cytauxzoon felis Cases in Domestic Cats from Eastern Kansas, a Retrospective Case-Control Study (2006–2019)

Veterinary Sciences, 2020
Cytauxzoon felis, a tick-borne hemoprotozoal pathogen of felids, causes an acute, often-fatal disease in domestic cats. While public awareness of the disease has increased, few studies have evaluated the incidence of acute cytauxzoonosis cases and their ...
Yvonne M. Wikander, Qing Kang, Kathryn E. Reif   +2 more
doaj   +1 more source

Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins. [PDF]

PLoS ONE, 2014
The invasion of Theileria sporozoites into bovine leukocytes is rapidly followed by the destruction of the surrounding host cell membrane, allowing the parasite to establish its niche within the host cell cytoplasm.
Olga Wiens, Dong Xia, Conrad von Schubert, Jonathan M Wastling, Dirk A E Dobbelaere, Volker T Heussler, Kerry L Woods   +6 more
doaj   +1 more source

Transcriptomics reveal potential vaccine antigens and a drastic increase of upregulated genes during Theileria parva development from arthropod to bovine infective stages. [PDF]

PLoS ONE, 2018
Theileria parva is a protozoan parasite transmitted by the brown ear tick Rhipicephalus appendiculatus that causes East Coast fever (ECF) in cattle, resulting in substantial economic losses in the regions of southern, eastern and central Africa.
Triza Tonui, Pilar Corredor-Moreno, Esther Kanduma, Joyce Njuguna, Moses N Njahira, Steven G Nyanjom, Joana C Silva, Appolinaire Djikeng, Roger Pelle   +8 more
doaj   +1 more source

Comparative Transcriptomics of the Bovine Apicomplexan Parasite Theileria parva Developmental Stages Reveals Massive Gene Expression Variation and Potential Vaccine Antigens

Frontiers in Veterinary Science, 2020
Theileria parva is a protozoan parasite that causes East Coast fever (ECF), an economically important disease of cattle in Africa. It is transmitted mainly by the tick Rhipicephalus appendiculatus.
Kodzo Atchou, Kodzo Atchou, Juliette Ongus, Eunice Machuka, Eunice Machuka, John Juma, Christian Tiambo, Appolinaire Djikeng, Joana C. Silva, Joana C. Silva, Roger Pelle   +10 more
doaj   +1 more source

Controlled human malaria infection (CHMI) outcomes in Kenyan adults is associated with prior history of malaria exposure and anti-schizont antibody response

BMC Infectious Diseases, 2022
Background Individuals living in endemic areas acquire immunity to malaria following repeated parasite exposure. We sought to assess the controlled human malaria infection (CHMI) model as a means of studying naturally acquired immunity in Kenyan adults ...
Melissa C. Kapulu, Domtila Kimani, Patricia Njuguna, Mainga Hamaluba, Edward Otieno, Rinter Kimathi, James Tuju, B. Kim Lee Sim, CHMI-SIKA Study Team   +8 more
doaj   +1 more source

Plasmodium Topoisomerase VIB and Spo11 Constitute Functional Type IIB Topoisomerase in Malaria Parasite: Its Possible Role in Mitochondrial DNA Segregation

Microbiology Spectrum, 2023
The human malaria parasite undergoes a noncanonical cell division, namely, endoreduplication, where several rounds of nuclear, mitochondrial, and apicoplast replication occur without cytoplasmic division. Despite its importance in Plasmodium biology, the
Priyanka Singh, Wahida Tabassum, Nupur Fangaria, Sandeep Dey, Siladitya Padhi, Mrinal K. Bhattacharyya, Kota Arun Kumar, Arijit Roy, Sunanda Bhattacharyya   +8 more
doaj   +1 more source