Results 121 to 130 of about 8,777,452 (313)

Effective pre-school, primary and secondary education project (EPPSE 3-14) : influences on students' attainment and progress in key stage 3 : academic outcomes in English, maths and science in year 9 [PDF]

, 2011
The Effective Pre-school, Primary and Secondary Education Project (EPPSE) has investigated the academic and social-behavioural development of approximately 3,000 children from the age of 3+ years since 1997.
Draghici, Diana, Melhuish, Edward, Sammons, Pam, Siraj-Blatchford, Iram, Smees, Rebecca, Sylva, Kathy, Taggart, Brenda, Toth, Katalin   +7 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Health-Saving Competence of Future Primary School Teachers: Indicators of Development [PDF]

, 2020
The research revealed an increasing interest of scientists to the problem of formation of health-saving competence of future primary school teachers. This tendency is due to the need for a social inquiry to modernize the training of future educators ...
Бондаренко, Геннадій Леонідович, Васьківська, Галина Олексіївна, Ващенко, Олена Миколаївна, Науменко, Марина Сергіївна, Нежива, Людмила Львівна, Паламар, Світлана Павлівна   +5 more
core  

Raum schafft Struktur und Strukturen schaffen Raum

WE_OS-Jahrbuch
Im Artikel wird die Entwicklung der Universitätsschule Dresden (USD) entlang des Ringens um den Schulbau beschrieben. Die USD, welche 2019 als Schulversuchsschule gestartet ist, verfolgt ein innovatives Lernkonzept, das individuelle Entwicklungswege in ...
Anke Langner, Matthias Ritter
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Strong Leaders Strong Schools: 2007 State Laws [PDF]

, 2008
Summarizes state laws enacted during the 2007 sessions to support school leadership initiatives, including efforts to improve statewide standards, training, mentoring, certification, professional development, assessment, compensation, and ...
Sara Vitaska Shelton
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Follow Up: Medical Rhetoric – Making the Case for Oral Presentations [PDF]

, 2019
Goal: •Oral case presentation skill is fundamental in clinical communication •This skill is first developed in medical school pre-clinical training •Continued development is often by “Trial and Error” – often without a formal curriculum Purpose ...
Qaiser, Rabia
core   +1 more source