Results 111 to 120 of about 64,431 (291)

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

A Developmentally Regulated Switch Directs Regenerative Growth of Schwann Cells through Cyclin D1

, 2000
Sciatic nerve axons in cyclin D1 knockout mice develop normally, become properly ensheathed by Schwann cells, and appear to function normally. However, in the Wallerian degeneration model of nerve injury, the mitotic response of Schwann cells is ...
Sicinski, Piotr, Kim, Haesun A., Pawlitzky, Inka, Whoriskey, Wendy, Benowitz, Larry I., Roberts, Thomas M., Stiles, Charles D., Pomeroy, Scott L.   +7 more
core   +1 more source

Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves [PDF]

, 2015
The peripheral nervous system has remarkable regenerative capacities in that it can repair a fully cut nerve. This requires Schwann cells to migrate collectively to guide regrowing axons across a ‘bridge’ of new tissue, which forms to reconnect a severed
Mackenzie, FE, Lloyd, AC, Burden, Jemima J., Hoving, JJ, Mackenzie, Francesca E., Rosenberg, Laura H., Garcia Calavia, N, Quereda, Victor, Cattin, A-L, McLaughlin, M, Cattin, AL, Napoli, I, Enver, T, Quereda, V, Parrinello, S, Napoli, Ilaria, Ruhrberg, C, Guo, Yanping, Jamecna, D, Burden, JJ, Hoving, Julian J.A., Hoving, JJA, Rosenberg, LH, Ruhrberg, Christiana, Parrinello, Simona, Jamecna, Denisa, Guo, Y, Garcia Calavia, Noelia, Van Emmenis, L, Lloyd, Alison C., McLaughlin, Maeve, Enver, Tariq, Calavia, NG, Cattin, Anne-Laure, Van Emmenis, Lucie   +34 more
core   +1 more source

Runx2 regulates peripheral nerve regeneration to promote Schwann cell migration and re-myelination

Neural Regeneration Research
Runx2 is a major regulator of osteoblast differentiation and function; however, the role of Runx2 in peripheral nerve repair is unclear. Here, we analyzed Runx2 expression following injury and found that it was specifically up-regulated in Schwann cells.
Rong Hu, Xinpeng Dun, Lolita Singh, Matthew C Banton   +3 more
doaj   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Functional dissection of the Oct6 schwann cell enhancer reveals an essential role for dimeric sox10 binding [PDF]

, 2011
The POU domain transcription factor Pou3f1 (Oct6/Scip/Tst1) initiates the transition from ensheathing, promyelinating Schwann cells to myelinating cells.
Maas, A. (Alex), Meijer, D.N. (Dies), Ghazvini, Mehrnaz, A. Maas, Jaegle, Martine, Svaren, J. (John), S. Driegen, Jones, Erin A, Jones, E.A. (Erin), J. Svaren, Driegen, Siska, Jagalur Basheer, Noorjahan, Grosveld, Frank, Svaren, J, M. Ghazvini, Jagalur, Noorjahan B, Maas, Alex, Mandemakers, Wim, Driegen, S, E. A. Jones, D. Meijer, M. Jaegle, Svaren, John, Ghazvini, M. (Mehrnaz), Meijer, Dies; id_orcid, F. Grosveld, Jagalur, N.B. (Noorjahan ), W. Mandemakers, Meijer, Dies, Mandemakers, W, Jones, EA, Mandemakers, W.J. (Wim), Driegen, M.J.F. (Siska), Grosveld, F.G. (Frank), Jaegle, M. (Martine), N. B. Jagalur   +35 more
core   +1 more source

Engineered Neural Tissue (EngNT) Containing Human iPSC-Derived Schwann Cell Precursors Promotes Axon Growth in a Rat Model of Peripheral Nerve Injury

Bioengineering
Tissue engineering has the potential to overcome the limitations of using autografts in nerve gap repair, using cellular biomaterials to bridge the gap and support neuronal regeneration.
Rebecca A. Powell, Emily A. Atkinson, Poppy O. Smith, Rickie Patani, Parmjit S. Jat, Owein Guillemot-Legris, James B. Phillips   +6 more
doaj   +1 more source

MicroRNA changes of bone marrow-derived mesenchymal stem cells differentiated into neuronal-like cells by Schwann cell-conditioned medium

Neural Regeneration Research, 2019
Bone marrow-derived mesenchymal stem cells differentiate into neurons under the induction of Schwann cells. However, key microRNAs and related pathways for differentiation remain unclear.
Zhi-Jian Wei, Bao-You Fan, Yang Liu, Han Ding, Hao-Shuai Tang, Da-Yu Pan, Jia-Xiao Shi, Peng-Yuan Zheng, Hong-Yu Shi, Heng Wu, Ang Li, Shi-Qing Feng   +11 more
doaj   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Schwann cell spectrins modulate peripheral nerve myelination

, 2011
During peripheral nerve development, Schwann cells ensheathe axons and form myelin to enable rapid and efficient action potential propagation. Although myelination requires profound changes in Schwann cell shape, how neuron–glia interactions converge on ...
Matthew N. Rasband, Keiichiro Susuki, Yasuhiro Ogawa, Michael C. Stankewich, Elior Peles, Alya R. Raphael, William S. Talbot   +6 more
core   +1 more source