Results 101 to 110 of about 64,431 (291)

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Force stimulation promotes nerve regeneration by restoring cellular energy

BMEMat, EarlyView.
Mechanical stimulation can help nerves regenerate in various ways. We developed two devices (a piezo‐motor‐driven stretching device and a SAW‐based actuator) to apply mechanical stimulation to sciatic nerve and DRG neurons. Our study shows that appropriate mechanical force stimulation can promote regeneration by restoring the energy supply to the ...
Zhe Wang, Chen Cai, Hetao Xie, Yupeng Yang, Lei Li, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Meiwan Chen, Yuanhua Sang, Bing Ji, Zenan Wang   +10 more
wiley   +1 more source

Schwann Cell–Derived Desert Hedgehog Controls the Development of Peripheral Nerve Sheaths

, 1999
We show that Schwann cell–derived Desert hedgehog (Dhh) signals the formation of the connective tissue sheath around peripheral nerves. mRNAs for dhh and its receptor patched (ptc) are expressed in Schwann cells and perineural mesenchyme, respectively ...
Turmaine, Mark, Jessen, Kristjan R, Namini, Soheila Sharghi, Lawson, Durward, Mirsky, Rhona, Chakrabarti, Lisa, Parmantier, Eric, Lynn, Bruce, McMahon, Andrew P   +8 more
core   +1 more source

Heterophilic Binding of L1 on Unmyelinated Sensory Axons Mediates Schwann Cell Adhesion and Is Required for Axonal Survival [PDF]

, 1999
This study investigated the function of the adhesion molecule L1 in unmyelinated fibers of the peripheral nervous system (PNS) by analysis of L1- deficient mice. We demonstrate that L1 is present on axons and Schwann cells of sensory unmyelinated fibers,
J. Roder, B.D. Trapp, Z. Sahenk, Trapp, B.D, Haney, C.A, C. Li, V.P. Lemmon, Sahenk, Z, Lemmon, V.P, Li, C, C.A. Haney, Roder, J   +11 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Neuregulins in schwann cell development

, 1999
In the PNS, Schwann cells are important both as support cells for small, unmyelinated axons, and for support and the production of myelin sheaths around larger axons, thereby permitting rapid axonal conduction.
Felts, Paul A.; id_orcid
core   +1 more source

Chemical conversion of human fibroblasts into functional schwann cells [PDF]

, 2014
Direct transdifferentiation of somatic cells is a promising approach to obtain patient-specific cells for numerous applications. However, conversion across germ-layer borders often requires ectopic gene expression with unpredictable side effects.
Roberto Iacone, Graf, M, Heckel, T, Frederic Knoflach, Jagasia, R, Tobias Heckel, Ravi Jagasia, Sannah Jensen Zoffmann, Flint, N, Jensen, ZS, Rachel Haab, Sebastian Jessberger, Flint, Nicholas, Eva C. Thoma, Claudia Merkl, Haab, Rachel, Jessberger, Sebastian, Petitjean, P, Graf, Martin, Thoma, Eva C, Nowaczyk, C, Truong, HH, Knoflach, F, Heckel, Tobias, Petitjean, Pascal, Iacone, R, Merkl, Claudia, Nowaczyk, Corinne, Corinne Nowaczyk, Jagasia, Ravi, Thoma, EC, Haab, R, Iacone, Roberto, Hoa Hue Truong, Knoflach, Frederic, Thoma, Eva C., Nicholas Flint, Pascal Petitjean, Martin Graf, Jensen Zoffmann, Sannah, Merkl, C, Jessberger, S, Truong, Hoa Hue   +42 more
core   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Schwann cell durotaxis can be guided by physiologically relevant stiffness gradients

Biomaterials Research, 2018
Background Successful nerve regeneration depends upon directed migration of morphologically specialized repair state Schwann cells across a nerve defect.
Elisabeth B. Evans, Samantha W. Brady, Anubhav Tripathi, Diane Hoffman-Kim   +3 more
doaj   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source