Results 121 to 130 of about 102,370 (356)

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

Downregulation of BST2 Rescues Cochlear Nerve Demyelination in Age-Related Hearing Loss via Enhancing Schwann Cell Migration. [PDF]

Aging Cell
The illustration indicates that increased BST2 expression in Schwann cells leads to cochlear nerve demyelination, accelerating hearing loss in ARHL. The upregulation of BST2 reduces POU6F1 expression by activating the NF‐κB pathway, which impairs MPZ transcription and Schwann cell migration, ultimately contributing to neural demyelination in ARHL ...
Liu M, Li Q, Cao H, Yin H, Yang J, Liu T, Wang J, Zhao L, Wang B.   +8 more
europepmc   +2 more sources

Single-Cell Transcriptomic Analysis Links Nonmyelinating Schwann Cells to Proinflammatory Response in the Lung [PDF]

, 2023
Jose E. Heredia, Min Jung, Alessia Balestrini, Jonas Doerr, Andrés Paler-Martı́nez, Alessandro M. Mozzarelli, Lorena Riol‐Blanco, Joshua S. Kaminker, Ning Ding   +8 more
openalex   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Harnessing Piezoelectric Biomaterials for Pathogenic Eradication and Tissue Regeneration

Exploration, EarlyView.
This review highlights recent advances in piezoelectric biomaterials for antibacterial therapy and tissue regeneration, discussing material classifications, catalytic mechanisms, property enhancements, biomedical applications, and future challenges in clinical translation.
Wenxuan Mao, Xiaoye Li, Ao He, Meng Ding, Yu Zhang, Zhuo Dai, Qiang Li, Weijun Xiu, Yanling Hu, Yongbin Mou, Dongliang Yang, Heng Dong   +11 more
wiley   +1 more source

C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurons [PDF]

, 2009
Ichiro Kishimoto, Takeshi Tokudome, Hideki Chusho, Kazuwa Nakao, Kenji Kangawa   +4 more
openalex   +1 more source

Value of 2‐Dimensional Shear‐Wave Elastography in Assessing Tibial Nerve Stiffness in Diabetic Peripheral Neuropathy

Journal of Ultrasound in Medicine, EarlyView.
Objectives The morphological alterations of the tibial nerve in patients with diabetes mellitus, both with and without diabetic peripheral neuropathy (DPN), are challenging to differentiate using B‐mode ultrasound. In this study, we assessed the stiffness changes of the tibial nerve by 2‐dimensional shear‐wave elastography (2D‐SWE). Methods We gathered
Jiafan Li, Shaozhi Cai, Yuxia Zhai, Ruoting Zheng, Junbin Du   +4 more
wiley   +1 more source

Transplanted olfactory ensheathing cells promote regeneration of cut adult rat optic nerve axons [PDF]

, 2003
Transplantation of olfactory ensheathing cells into spinal cord lesions promotes regeneration of cut axons into terminal fields and functional recovery.
Li, D., Li, Y., Lund, R.D., Raisman, G., Sauvé, Y.   +4 more
core  

Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng, Ling‐Li Chang, Hung‐Chen Wang, Wei‐Chun Hung, Chia‐Hua Hsieh, Yi‐Hsuan Wang, Kuang‐I Cheng   +6 more
wiley   +1 more source

Enhancing therapeutic potential: Human adipose‐derived mesenchymal stem cells modified with recombinant adeno‐associated virus expressing VEGF165 gene for peripheral nerve injury

Kaohsiung Journal of Medical Sciences
This study aimed to investigate the therapeutic potential of human adipose‐derived mesenchymal stem cells (hADSCs) modified with recombinant adeno‐associated virus (rAAV) carrying the vascular endothelial growth factor 165 (VEGF165) gene in peripheral ...
Shuai Jiang, Bo Chen, Zhen‐Yu Sun
doaj   +1 more source