Results 121 to 130 of about 128,417 (336)

Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles

Advanced Science, EarlyView.
Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang, Shiying Zhang, Irene Shuping Zhao, Xueqi Gan, Yang Zhang   +4 more
wiley   +1 more source

Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering

Aggregate, EarlyView.
Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang, Alice Le Friec, Menglin Chen, Di Sun   +3 more
wiley   +1 more source

The glia response after peripheral nerve injury: A comparison between Schwann cells and olfactory ensheathing cells and their uses for neural regenerative therapies [PDF]

, 2017
The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems.
Barton, Matthew J., Clarke, Mary, Ekberg, Jenny, St. John, James, Wright, Alison   +4 more
core   +2 more sources

Distinct Alterations of Inflammatory Biomarkers in Cluster Headache: A Case Control Study

Annals of Neurology, EarlyView.
Objective Investigate the immune system's role in cluster headache by analyzing cytokines in people with cluster headache and headache‐free controls, and explore if certain cytokines could predict a specific phenotype. Methods We measured 45 cytokines in adult participants from the Danish Cluster Headache Biobank in a prospective case–control setup ...
Nunu Laura Timotheussen Lund, Connar Stanley James Westgate, Marie‐Louise Kulas Søborg, Agneta Henriette Snoer, Rigmor Højland Jensen, Thomas Folkman Hansen, Anja Sofie Petersen   +6 more
wiley   +1 more source

Skeletal Stem Cell-Schwann Cell Circuitry in Mandibular Repair

Cell Reports, 2019
Summary: Regenerative paradigms exhibit nerve dependency, including regeneration of the mouse digit tip and salamander limb. Denervation impairs regeneration and produces morphological aberrancy in these contexts, but the direct effect of innervation on ...
R. Ellen Jones, Ankit Salhotra, Kiana S. Robertson, Ryan C. Ransom, Deshka S. Foster, Harsh N. Shah, Natalina Quarto, Derrick C. Wan, Michael T. Longaker   +8 more
doaj  

Schwann cell durotaxis can be guided by physiologically relevant stiffness gradients

Biomaterials Research, 2018
Background Successful nerve regeneration depends upon directed migration of morphologically specialized repair state Schwann cells across a nerve defect.
Elisabeth B. Evans, Samantha W. Brady, Anubhav Tripathi, Diane Hoffman-Kim   +3 more
doaj   +1 more source

Aging Schwann cells in vitro

European Journal of Cell Biology, 2007
Schwann cells (SCs) can support the regeneration of lesioned fiber tracts of the peripheral and central nervous system and have been transplanted alone or in combination with synthetic nerve guides. For neuronal tissue engineering purposes, the cells must be isolated from small biopsies and expanded in vitro. In this study we analyze the impact of cell
Burkhard Schlosshauer, Cornelia Fricke, Dorothee Funk   +2 more
openaire   +2 more sources

Secretome survey of human plexiform neurofibroma derived schwann cells reveals a secreted form of the RARRES1 protein. [PDF]

, 2012
To bring insights into neurofibroma biochemistry, a comprehensive secretome analysis was performed on cultured human primary Schwann cells isolated from surgically resected plexiform neurofibroma and from normal nerve tissue.
Brown, Kristy J., Chen, Hui-Ling, Gallo, Vittorio, Gordish-Dressman, Heather, Hathout, Yetrib, Hill, D. Ashley, Packer, Roger J., Seol, Haeri   +7 more
core   +3 more sources

Decoding regulatory programs underlying placode and dermal condensate cell fate commitment during hair follicle induction via single‐cell multi‐omics analysis

Animal Research and One Health, EarlyView.
The experimental framework of the study encompasses sample collection, single‐cell data analysis, and experimental validation. Abstract Understanding differences in chromatin state and changes in gene regulatory landscape of placode (Pc) and dermal condensate are crucial for decoding hair follicle (HF) morphogenesis programs.
Fang Li, Minghao Li, Tongtong Zhang, Menghua Sui, Hasan Khatib, Xin Wang   +5 more
wiley   +1 more source

Regulative Differentiation as Bifurcation of Interacting Cell Population [PDF]

arXiv, 2007
In multicellular organisms, several cell states coexist. For determining each cell type, cell-cell interactions are often essential, in addition to intracellular gene expression dynamics. Based on dynamical systems theory, we propose a mechanism for cell differentiation with regulation of populations of each cell type by taking simple cell models with ...
arxiv