Schwann cell interactions during the development of the peripheral nervous system
Developmental Neurobiology, 2020 Schwann cells play a critical role in the development of the peripheral nervous system (PNS), establishing important relationships both with the extracellular milieu and other cell types, particularly neurons.
E. R. Wilson +4 more
semanticscholar +1 more source
Mining Gene Ontology Data with AGENDA
Bioinformatics and Biology Insights, 2012 The Gene Ontology (GO) initiative is a collaborative effort that uses controlled vocabularies for annotating genetic information. We here present AGENDA ( A pplication for mining Gen e Ontology Da ta), a novel web-based tool for accessing the GO database.
Guvanch Ovezmyradov +2 more
doaj +1 more source
FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis [PDF]
, 2007 After injury, the CNS undergoes an astrocyte stress response characterized by reactive astrocytosis/proliferation, boundary formation, and increased glial fibrillary acidic protein (GFAP) and chondroitin sulfate proteoglycan (CSPG) expression. Previously,
Barnett, S.C. +7 more
core +3 more sources
The Success and Failure of the Schwann Cell Response to Nerve Injury
Frontiers in Cellular Neuroscience, 2019 The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin) and myelin phenotypes, which are specialized to meet the needs of small and large diameter axons, and differ markedly from each other.
K. Jessen, R. Mirsky
semanticscholar +1 more source
Rab27a/Slp2-a complex is involved in Schwann cell myelination
Neural Regeneration Research, 2016 Myelination of Schwann cells in the peripheral nervous system is an intricate process involving myelin protein trafficking. Recently, the role and mechanism of the endosomal/lysosomal system in myelin formation were emphasized.
Wen-feng Su +7 more
doaj +1 more source
Embryonic Corneal Schwann Cells Express Some Schwann Cell Marker mRNAs, but No Mature Schwann Cell Marker Proteins [PDF]
Investigative Opthalmology & Visual Science, 2009 Embryonic chick nerves encircle the cornea in pericorneal tissue until embryonic day (E)9, then penetrate the anterior corneal stroma, invade the epithelium, and branch over the corneal surface through E20. Adult corneal nerves, cut during transplantation or LASIK, never fully regenerate.
Abigail H, Conrad +3 more
openaire +2 more sources
Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination [PDF]
, 2017 Effective bidirectional signalling between axons and Schwann cells is essential for both the development and maintenance of peripheral nerve function. We have established conditions by which human induced pluripotent stem cell-derived sensory neurons can
Bennett, David L.H. +5 more
core +2 more sources
Repair Schwann cell update: Adaptive reprogramming, EMT, and stemness in regenerating nerves
Glia, 2019 Schwann cells respond to nerve injury by cellular reprogramming that generates cells specialized for promoting regeneration and repair. These repair cells clear redundant myelin, attract macrophages, support survival of damaged neurons, encourage axonal ...
K. Jessen, P. Arthur-Farraj
semanticscholar +1 more source
Transcriptional Regulation Induced by cAMP Elevation in Mouse Schwann Cells
ASN Neuro, 2014 In peripheral nerves, Schwann cell development is regulated by a variety of signals. Some of the aspects of Schwann cell differentiation can be reproduced in vitro in response to forskolin, an adenylyl cyclase activator elevating intracellular cAMP ...
Daniela Schmid +2 more
doaj +1 more source
Schwann cells promote endothelial cell migration [PDF]
Cell Adhesion & Migration, 2015 Directed cell migration is a crucial orchestrated process in embryonic development, wound healing, and immune response. The underlying substrate can provide physical and/or chemical cues that promote directed cell migration. Here, using electrospinning we developed substrates of aligned poly(lactic-co-glycolic acid) nanofibres to study the influence of
Ramos, Tiago +3 more
openaire +2 more sources