Results 31 to 40 of about 49,600 (309)

Skeletal Stem Cell-Schwann Cell Circuitry in Mandibular Repair

Cell Reports, 2019
Summary: Regenerative paradigms exhibit nerve dependency, including regeneration of the mouse digit tip and salamander limb. Denervation impairs regeneration and produces morphological aberrancy in these contexts, but the direct effect of innervation on ...
R. Ellen Jones, Ankit Salhotra, Kiana S. Robertson, Ryan C. Ransom, Deshka S. Foster, Harsh N. Shah, Natalina Quarto, Derrick C. Wan, Michael T. Longaker   +8 more
doaj   +1 more source

Notch and Schwann cell transformation [PDF]

Oncogene, 2004
Benign plexiform neurofibromas in NF1 patients can transform spontaneously into malignant peripheral nerve sheath tumors (MPNSTs). Although mutations in the p53 gene have been found in a subset of MPNSTs and mouse models support a role for p53 mutations in malignant conversion, we found that each of three Schwann cell lines derived from human MPNSTs ...
Peggy Wallace, Rong Wen, Ying Song, Prakash K. Rao, Prakash K. Rao, Samantha J van Horne, Tom Kadesch, David Muir, Yiwen Li, Gihan Tennekoon   +9 more
openaire   +3 more sources

Insights Into the Role and Potential of Schwann Cells for Peripheral Nerve Repair From Studies of Development and Injury

Frontiers in Molecular Neuroscience, 2021
Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self-repair, lifelong disability is common. New molecular and cellular insights
Anjali Balakrishnan, Anjali Balakrishnan, Lauren Belfiore, Lauren Belfiore, Tak-Ho Chu, Taylor Fleming, Rajiv Midha, Jeff Biernaskie, Carol Schuurmans, Carol Schuurmans, Carol Schuurmans   +10 more
doaj   +1 more source

miR-148b-3p promotes migration of Schwann cells by targeting cullin-associated and neddylation-dissociated 1

Neural Regeneration Research, 2016
MicroRNAs (miRNAs) are small, non-coding RNAs that negatively adjust gene expression in multifarious biological processes. However, the regulatory effects of miRNAs on Schwann cells remain poorly understood.
Tian-mei Qian, Li-li Zhao, Jing Wang, Ping Li, Jing Qin, Yi-sheng Liu, Bin Yu, Fei Ding, Xiao-song Gu, Song-lin Zhou   +9 more
doaj   +1 more source

Schwann Cells of the Bone Marrow [PDF]

Blood, 1970
Abstract Nerves containing numerous Schwann cells can be found in bone marrow with routine histological methods. Thin nerve bundles and single nerve fibers containing Schwann cells can be identified histologically with help of methods which demonstrate nerve fibers and myelin. Smears of marrow stained with the May-Grünwald-Giemsa method
Jerónimo Forteza-Vila, Wenceslao Calvo
openaire   +3 more sources

Glial Fibrillary Acidic Protein Astrocytopathy Based on a Two‐Center Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glial fibrillary acidic protein astrocytopathy (GFAP‐A) is a recently defined nosological form belonging to the class of autoimmune inflammatory disorders affecting the central nervous system (CNS). Here, we report the clinical and MRI characteristics, treatment, and prognosis of a GFAP‐A cohort from two centers in China.
Ti Wu, Hao Zhang, Chao Gao, Qiuhua Yu, Moli Fan, Lin‐Jie Zhang, Haipeng Zhang, Hengri Cong, Yuzhen Wei, Chotima Böttcher, Alexej Verkhratsky, Friedemann Paul, Fu‐Dong Shi, Tian Song   +13 more
wiley   +1 more source

Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury

Neural Regeneration Research, 2017
Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury.
Bin Pan, Zhong-ju Shi, Jia-yin Yan, Jia-he Li, Shi-qing Feng   +4 more
doaj   +1 more source

Calcium Signaling in Schwann cells

Neuroscience Letters, 2020
In addition to providing structural, metabolic and trophic support to neurons, glial cells of the central, peripheral and enteric nervous systems (CNS, PNS, ENS) respond to and regulate neural activity. One of the most well characterized features of this response is an increase of intracellular calcium.
Thomas W. Gould, Camilla Fedi, Dante J. Heredia, Claire De Angeli   +3 more
openaire   +4 more sources

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Lithium promotes proliferation and suppresses migration of Schwann cells

Neural Regeneration Research, 2020
Schwann cell proliferation, migration and remyelination of regenerating axons contribute to regeneration after peripheral nervous system injury. Lithium promotes remyelination by Schwann cells and improves peripheral nerve regeneration.
Xiao-Kun Gu, Xin-Rui Li, Mei-Ling Lu, Hui Xu   +3 more
doaj   +1 more source