Results 61 to 70 of about 128,417 (336)

Cell-to-cell variation sets a tissue-rheology-dependent bound on collective gradient sensing [PDF]

PNAS (2017), 2017
When a single cell senses a chemical gradient and chemotaxes, stochastic receptor-ligand binding can be a fundamental limit to the cell's accuracy. For clusters of cells responding to gradients, however, there is a critical difference: even genetically identical cells have differing responses to chemical signals.
arxiv   +1 more source

Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices. [PDF]

, 1986
We have compared neurite outgrowth on extracellular matrix (ECM) constituents to outgrowth on glial and muscle cell surfaces. Embryonic chick ciliary ganglion (CG) neurons regenerate neurites rapidly on surfaces coated with laminin (LN), fibronectin (FN),
Bixby, JL, Reichardt, LF, Tomaselli, KJ
core   +1 more source

Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine

Advanced Functional Materials, EarlyView.
Chiral engineered biomaterials can selectively influence cell behaviors in regenerative medicine. This review covers chiral engineered biomaterials in terms of their fabrication methods, cellular response mechanisms, and applications in directing stem cell differentiation and tissue function.
Yuwen Wang, Xin Zhang, Denghui Xie, Chunying Chen, Zhifeng Huang, Zhong Alan Li   +5 more
wiley   +1 more source

Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis

Cell Reports, 2023
Summary: Schwann cells play critical roles in peripheral neuropathies; however, the regulatory mechanisms of their homeostasis remain largely unknown. Here, we show that nucleoporin Seh1, a component of nuclear pore complex, is important for Schwann cell
Mei Wu, Man Li, Wei Liu, Minbiao Yan, Li Li, Weichao Ding, Ximing Nian, Wenxiu Dai, Di Sun, Yanqin Zhu, Qiuying Huang, Xiaoyun Lu, Zhiyu Cai, Fan Hong, Xuewen Li, Ling Zhang, Zhixiong Liu, Wei Mo, Xueqin Zhang, Liang Zhang   +19 more
doaj  

Iron role paradox in nerve degeneration and regeneration [PDF]

Bolandghamat, S., & Behnam-Rassouli, M. (2024). Iron role paradox in nerve degeneration and regeneration. Physiological Reports, 12, e15908
Iron accumulates in the neural tissue during peripheral nerve degeneration. Some studies have already been suggested that iron facilitates Wallerian degeneration (WD) events such as Schwann cell de-differentiation. On the other hand, intracellular iron levels remain elevated during nerve regeneration and gradually decrease.
arxiv   +1 more source

Studies on cultured Schwann cells: the induction of myelin synthesis, and the control of their proliferation by a new growth factor [PDF]

, 1981
We have recently described the use of immunological methods to identify and purify rat Schwann cells. In dissociated cultures of neonatal sciatic nerve, all of the cells can be identified by antigenic criteria as either Schwann cells or fibroblasts.
Brockes, J. P., Fryxell, K. J., Lemke, G. E.   +2 more
core  

Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction

Advanced Healthcare Materials, EarlyView.
This study develops a graft‐host skeletal muscle assembloid model combining neuromuscular organoids with tissue‐engineered constructs. Pre‐seeding decellularized muscles with myogenic cells enhances cell migration and axon invasion from the organoid. The model exhibits regenerative capacity following acute damage, advancing the understanding of human ...
Lucia Rossi, Beatrice Auletta, Luigi Sartore, Marco La Placa, Giada Cecconi, Pietro Chiolerio, Edoardo Maghin, Silvia Angiolillo, Eugenia Carraro, Onelia Gagliano, Cecilia Laterza, Nicola Elvassore, Martina Piccoli, Anna Urciuolo   +13 more
wiley   +1 more source

The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury. [PDF]

, 2015
BackgroundMechanical pain hypersensitivity associated with physical trauma to peripheral nerve depends on T-helper (Th) cells expressing the algesic cytokine, interleukin (IL)-17A.
Angert, Mila, Chernov, Andrei V, Dolkas, Jennifer, Hoang, Khan, Liu, Huaqing, Nishihara, Tasuku, Remacle, Albert G, Shiryaev, Sergey A, Shubayev, Veronica I, Strongin, Alex Y   +9 more
core   +3 more sources

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Malignant ectomesenchymoma in children: The European pediatric Soft tissue sarcoma Study Group experience

Pediatric Blood &Cancer, Volume 70, Issue 2, February 2023., 2023
Abstract Malignant ectomesenchymoma (MEM) is an extremely rare soft tissue tumor typical of young children, currently included in the category of skeletal muscle malignancies and characterized by a neuroblastic component. This study describes a series of 10 patients prospectively registered in the European paediatric Soft tissue sarcoma Study Group ...
Giuseppe Maria Milano, Daniel Orbach, Michela Casanova, Pablo Berlanga, Reineke A. Schoot, Nadege Corradini, Bernadette Brennan, Gema L. Ramirez‐Villar, Lisa Lyngsie Hjalgrim, Max M. van Noesel, Rita Alaggio, Andrea Ferrari   +11 more
wiley   +1 more source